Tragacanth Gum/Chitosan Polyelectrolyte Complexes-Based Hydrogels Enriched with Xanthan Gum as Promising Materials for Buccal Application

Abstract

Polyelectrolyte complexes based on the electrostatic interactions between the polymers mixed are of increasing importance, therefore, the aim of this study was to develop hydrogels composed of anionic tragacanth gum and cationic chitosan with or without the addition of anionic xanthan gum as carriers for buccal drug delivery. Besides the routine quality tests evaluating the hydrogel’s applicability on the buccal mucosa, different methods directed toward the assessment of the interpolymer complexation process (e.g., turbidity or zeta potential analysis, scanning electron microscopy and Fourier-transform infrared spectroscopy) were employed. The addition of xanthan gum resulted in stronger complexation of chitosan that affected the hydrogel’s characteristics. The formation of a more viscous PEC hydrogel with improved mucoadhesiveness and mechanical strength points out the potential of such polymer combination in the development of buccal drug dosage forms.

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

“…The spectrums were recorded in transmittance mode with 66 scans and a resolution of 2 cm −1 from 4000 to 600 cm −1 . The spectra obtained were recorded and analysed to determine the functional groups present in the polysaccharide [ 37 ]. 32 scans were done and averaged to achieve a satisfactory signal-to-noise ratio [ 38 ].…”

“…The contact angle was determined using a Rame goniometer as a direct tool. An aqueous solution of samples (1% w / v ) was produced and cast on a glass surface, then vacuum dried at 40 °C [ 37 ].…”

Multilayer Films Based on Chitosan/Pectin Polyelectrolyte Complexes as Novel Platforms for Buccal Administration of Clotrimazole

“…Performance of the films in the presence of SS was assessed with reference to our previously described method for CS/tragacanth/xanthan gum hydrogels, for buccal administration [43]. Given the variations in the drug release profiles observed for different pH conditions (Section 3.7.…”

Potential of mucoadhesive chitosan glutamate microparticles as microbicide carriers – antiherpes activity and penetration behavior across the human vaginal epithelium

“…Chitosan is a natural copolymer derived from chitin which consists of glucosamine and N-acetylglucosamine units. With regard to its cationic nature, chitosan binds to mucosal surfaces and thus has been extensively studied for a number of biomedical and pharmaceutical applications (Ahmed & Aljaeid, 2016 ; Ahsan et al, 2018 ; Potaś et al, 2020 ). We have previously shown that chitosan could be successfully used in the technology of carriers for vaginal candidiasis treatment (Szymańska et al, 2014 ).…”