Traffic-related Air Pollution, Lung Function, and Host Vulnerability. New Insights from the PARIS Birth Cohort

Bougas, Nicolas; Rancière, Fanny; Beydon, Nicole; Viola, Malika; Perrot, Xavier; Gabet, Stephan; Lezmi, Guillaume; Amat, Flore; Blic, J. de; Just, Jocelyne; Momas, Isabelle

doi:10.1513/annalsats.201711-900oc

Cited by 31 publications

(31 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lung function tests were carried out at 8‐9 years, as previously described . Spirometry was performed at baseline and 20 minutes after the administration of 200 μg of salbutamol.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Unsupervised trajectories of respiratory/allergic symptoms throughout childhood in the PARIS cohort

Bougas

Just

Beydon

et al. 2019

Pediatric Allergy Immunology

Self Cite

View full text Add to dashboard Cite

Background Natural course and co‐occurrence of asthma, eczema, and allergic rhinitis through childhood are still not fully documented. We aim to identify and characterize profiles based on the time course, severity, and apparent triggers of respiratory/allergy symptoms in school‐aged children. Methods Data on occurrence, severity, and triggers of asthma, rhinitis, and dermatitis symptoms were collected annually during the follow‐up of the PARIS birth cohort. Children with similar symptom trajectories until 8‐9 years were grouped into profiles using multidimensional (all symptoms considered simultaneously) cluster analysis. Associations between profiles and different health outcomes were analyzed using logistic or linear regression models. Results Six distinct symptomatic profiles were identified. A profile was defined by persistent dermatitis symptoms, associated with sensitization to food and aeroallergens. Two profiles were characterized by wheezing: one with early transient wheezing and the other with persistent wheezing related to doctor‐diagnosed asthma, airway obstruction, and perennial aeroallergen sensitization. Three profiles were characterized by rhinitis symptoms: one non‐allergic and two allergic, either with persistent rhinitis symptoms related to allergic multimorbidity and sensitization to perennial aeroallergens, or with late‐onset symptoms, related to both pollen and perennial aeroallergens sensitization as well as low lung function. Conclusion This study brings further insights into the developmental profiles of respiratory/allergic outcomes from birth to school age. The identified profiles clearly differed regarding objective features such as diagnosed morbidity, sensitization, or lung function measurements, thus highlighting their biologic and clinical relevance. Allergic rhinitis profiles deserve particular attention, since they were likely to be involved in multimorbidity patterns.

show abstract

“…Lung function tests were carried out at 8‐9 years, as previously described . Spirometry was performed at baseline and 20 minutes after the administration of 200 μg of salbutamol.…”

Section: Methodsmentioning

confidence: 99%

“…Lung function tests were carried out at 8-9 years, as previously described. 10 Spirometry was performed at baseline and 20 minutes after the administration of 200 μg of salbutamol. Forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC), and forced expiratory flow at 25%-75% of the FVC (FEF 25%-75% ) were recorded.…”

Section: Lung Functionmentioning

confidence: 99%

Unsupervised trajectories of respiratory/allergic symptoms throughout childhood in the PARIS cohort

Bougas

Just

Beydon

et al. 2019

Pediatric Allergy Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Different exposure windows during lung development have been investigated in order to identify a critical time frame. While some studies reported small-scale associations between higher air pollution exposure during pregnancy and reduced lung function at school-age (Bougas and Ranciere, 2018;Jedrychowski et al, 2010;Jedrychowski et al, 2015;Morales et al, 2015;Mortimer et al, 2008), other studies reported that exposure during infancy, but not pregnancy, was associated with reduced lung function at school-age (Schultz et al, 2012;Schultz et al, 2016). These conflicting findings suggest that different exposure windows during lung development may differently affect lung function.…”

Section: Introductionmentioning

confidence: 99%

“…Adverse effects of air pollution on lung function in newborns (Latzin et al, 2009), during childhood (Bougas and Ranciere, 2018;Jedrychowski et al, 2010;Jedrychowski et al, 2015;Morales et al, 2015;Mortimer et al, 2008;Schultz et al, 2012) and adolescence (Schultz et al, 2016) have been reported. Different exposure windows during lung development have been investigated in order to identify a critical time frame.…”

Section: Introductionmentioning

confidence: 99%

Exposure to moderate air pollution and associations with lung function at school-age: a birth cohort study

Usemann¹,

Decrue²,

Korten³

et al. 2019

Paediatric Respiratory Epidemiology

View full text Add to dashboard Cite

Background: Adverse effects of higher air pollution levels before and after birth on subsequent lung function are often reported in the literature. We assessed whether low-to-moderate levels of air pollution during preschoolage impact upon lung function at school-age. Methods: In a prospective birth cohort of 304 healthy term-born infants, 232 (79%) completed lung function at follow-up at six years. Using spatial-temporal models, levels of individual air pollution (nitrogen dioxide (NO 2) and ozone (O 3), particulate matter with a diameter < 10 μm (PM 10)) were estimated for the time windows pregnancy, first up to the sixth year of life separately, and birth until follow-up at six years. Time window means were compared to World Health Organization (WHO) guideline limits. Associations of exposure windows with spirometry and body plethysmography indices were analyzed using regression models, adjusting for potential confounders. For subgroup analysis, air pollution exposure was categorized into quartiles (four groups of 52 children). Results: Mean NO 2 level from birth until follow-up was [mean (range)] [11.8 (4.9 to 35.9 μg/m 3)], which is almost 4-times lower than the WHO suggested limit of 40 μg/m 3. In the whole population, increased air pollution levels from birth until follow-up were associated with reduced lung function at six years. In the subgroup analysis, the 52 children exposed to NO 2 levels from the highest quartile during pregnancy, the first and second years of life and from birth until follow-up, had a significant decrease in forced expiratory volume in 1 s (FEV 1). Per interquartile range increase of NO 2 , FEV 1 decreased by [z-score change (95% confidence interval)] [−1.07 (−1.67 to −0.47)], [−1.02 (−1.66 to −0.39)], [−0.51 (−0.86 to −0.17)] and [−0.80 (−1.33 to −0.27)], respectively. Air pollution exposure during pregnancy and childhood resulted in a non-significant decrease in lung volume at six years, as assessed by functional residual capacity measured by body plethysmography (FRC pleth). Conclusion: Our results suggest that exposure to higher NO 2 levels, which are still much lower than WHO guideline limits, especially during the sensitive period of early lung development, may be associated with reduced lung function at school-age. These findings support the concept of age and dose-dependent pollution effects on lung function in healthy school-aged children and underline the importance of pollution reduction measures.

show abstract

“…In animal toxicology, prenatal plus early postnatal exposure to PM 2.5 from motor vehicle sources has been found to impair lung growth (8), although little (if any) mechanistic research has focused on vulnerable periods during gestation. On the other hand, identifying an especially sensitive trimester has been of great interest in epidemiologic research, with inconclusive results (1,9,10). This question may be unanswerable with observational data because a trimester lasts 3 months and is therefore a snapshot of pollution exposure that aligns perfectly with season.…”

mentioning

confidence: 99%

Prenatal Air Pollution and Child Lung Function: The Impossible Search for a Vulnerable Trimester

Rice

Mein

2020

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Traffic-related Air Pollution, Lung Function, and Host Vulnerability. New Insights from the PARIS Birth Cohort

Abstract: This study sheds new light, suggesting associations between postnatal traffic-related air pollution exposure and reduced lung function may be enhanced by early, repeated lower respiratory tract infections or allergic sensitization.

Cited by 31 publications

References 29 publications

Unsupervised trajectories of respiratory/allergic symptoms throughout childhood in the PARIS cohort

Unsupervised trajectories of respiratory/allergic symptoms throughout childhood in the PARIS cohort

Exposure to moderate air pollution and associations with lung function at school-age: a birth cohort study

Prenatal Air Pollution and Child Lung Function: The Impossible Search for a Vulnerable Trimester

Contact Info

Product

Resources

About