Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: A review

Tian, Ting; Chen, Hua; Zhao, Ying-Yong

doi:10.1016/j.jep.2014.10.061

Cited by 137 publications

(80 citation statements)

References 99 publications

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“…Alismatis rhizome (AR), the dried rhizome of Alisma orientale (Sam.) Juzep, exhibited diuretic, antihyperlipidemic, and renoprotective effects that were also confirmed by our previous studies . Our recent study demonstrated that triterpenoid was the main component of AR, and further study showed that the novel tetracyclic triterpenoid 25‐O‐methylalisol F inhibited EMT by suppressing the Wnt/β‐catenin signaling pathway as well as the phosphorylation of Smad3 signaling in both NRK‐52E and NRK‐49F cells (Figure and Table ).…”

Section: Small Molecules Against Emtsupporting

confidence: 83%

Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis

Feng

Chen

Vaziri

et al. 2019

Medicinal Research Reviews

102

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Tissue fibrosis and cancer both lead to high morbidity and mortality worldwide; thus, effective therapeutic strategies are urgently needed. Because drug resistance has been widely reported in fibrotic tissue and cancer, developing a strategy to discover novel targets for targeted drug intervention is necessary for the effective treatment of fibrosis and cancer. Although many factors lead to fibrosis and cancer, pathophysiological analysis has demonstrated that tissue fibrosis and cancer share a common process of epithelial‐mesenchymal transition (EMT). EMT is associated with many mediators, including transcription factors (Snail, zinc‐finger E‐box‐binding protein and signal transducer and activator of transcription 3), signaling pathways (transforming growth factor‐β1, RAC‐α serine/threonine‐protein kinase, Wnt, nuclear factor‐kappa B, peroxisome proliferator‐activated receptor, Notch, and RAS), RNA‐binding proteins (ESRP1 and ESRP2) and microRNAs. Therefore, drugs targeting EMT may be a promising therapy against both fibrosis and tumors. A large number of compounds that are synthesized or derived from natural products and their derivatives suppress the EMT by targeting these mediators in fibrosis and cancer. By targeting EMT, these compounds exhibited anticancer effects in multiple cancer types, and some of them also showed antifibrotic effects. Therefore, drugs targeting EMT not only have both antifibrotic and anticancer effects but also exert effective therapeutic effects on multiorgan fibrosis and cancer, which provides effective therapy against fibrosis and cancer. Taken together, the results highlighted in this review provide new concepts for discovering new antifibrotic and antitumor drugs.

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Section: Small Molecules Against Emtsupporting

confidence: 83%

Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis

Feng

Chen

Vaziri

et al. 2019

Medicinal Research Reviews

102

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“…Juzep (Alismaceae), is a reputable diuretic traditional Chinese medicine (TCM) for the treatment of dysuria, edema, nephropathy, hyperlipidemia, diabetes, inflammation, tumors, and so on. . Phytochemical studies of A. orientale conducted previously led to the isolation of diverse terpenoids, including protostane‐type triterpenes, guaiane‐type sesquiterpenes, and kaurane‐type diterpenes.…”

Section: Introductionmentioning

confidence: 99%

Geographic impact evaluation of the quality of Alismatis Rhizoma by untargeted metabolomics and quantitative assay

Yang

Pan

et al. 2018

J of Separation Science

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The geographic impact on the quality of Alismatis Rhizoma (derived from the tuber of Alisma orientale), a reputable diuretic traditional Chinese medicine, has seldom been evaluated. Here a metabolomics-driven approach targeting the bioactive protostane triterpenes was developed, by incorporating UHPLC with quadrupole time-of-flight mass spectrometry-based untargeted metabolite profiling and multiple reaction monitoring quantitative assay, to probe the triterpene differences between Alismatis Rhizoma samples collected from Sichuan, Fujian, and Jiangxi Provinces. Following the metabolomics workflows, the samples from Sichuan and Jiangxi displayed distinct differences in their triterpene profiles, whereas those from Fujian showed remarkable intra-class variation. Twenty-three triterpenes were identified to contribute most to the differentiated clustering. A sensitive, precise, repeatable, and accurate quantitative assay method was established on a hybrid triple quadrupole-linear ion trap mass spectrometer to quantify the contents of eight triterpene compounds. Taking into account the metabolomics and quantitation results, alisol B 23-acetate and alisol A are significantly different in Alismatis Rhizoma from Sichuan and Jiangxi Provinces, and they may have the potential for geographic discrimination. These results illustrate how geographic difference impacts the triterpene chemistry of Alismatis Rhizoma. Metabolomics-driven chemical comparison is suitable for the quality evaluation of traditional Chinese medicine.

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“…Main chemical composition of Rhizoma Alismatis is the terpenoid including sesquiterpene, diterpene, and triterpene. The crude extracts and isolated compounds from Rhizoma Alismatis have diverse pharmacological activities including diuretic, nephroprotective, antihyperlipidemic, antiatherosclerotic, anticancer, anti-inflammatory, and antioxidative activities [17]. Recently, Li et al demonstrated that triterpenes from the Rhizoma Alismatis extract can decrease serum lipid level in the high-fat-diet induced hyperlipidemia mice [31].…”

Section: Discussionmentioning

confidence: 99%

“…Wan Da-Cheng, a grandmaster of Chinese Medicine, according to his long-term clinical experience, proposes that AS and HLP are inseparable, and the pathogenesis of HLP is mainly due to the blood stasis and congestion of arteries and veins by turbidity phlegm, advocating the concept that “ameliorating phlegm and stasis on the one hand, maintaining the liver normal function on the other hand.” He further developed the Tiaozhi granule to treat HLP patients in clinic, which is mainly composed of Pollen Typhae Angustifoliae, Curcuma longa L., and Rhizoma Alismatis . These components are also widely used in traditional Chinese medicine for the effects of antiatherosclerosis, anticancer, anti-inflammatory, and antioxidative activities [15–17]. Although various mechanisms have been identified for their therapeutic effects on treatment of clinical patients, the molecular mechanism related to the treatment of HLP and AS patients is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Effects of Extracts from Tiaozhi Granule and Its Components on Expression of Scavenger Receptor Class B Type I

Zhao

Bao

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Sera from the rats with different drug treatments (atorvastatin, Tiaozhi granule, or its extracts) were collected. LO-2 cells or HepG2 cells were pretreated with different sera as the following groups randomly: (1) blank control group, (2) positive control group (atorvastatin group), (3) Tiaozhi granule water extract groups, (4) Tiaozhi granule alcohol extract groups, and (5) alcohol extracts for each component: Pollen Typhae Angustifoliae, Curcuma longa L., and Rhizoma Alismatis. LO-2 cells were cotransfected with plasmid carrying SR-BI and pRL-TK promoter genes. Promoter activity was measured by the luciferase reporter gene assay. The mRNA and protein expressions of SR-BI were examined using real-time PCR and western blot analyses. Our results show that promoter activity and mRNA and protein expression levels of the SR-BI were significantly upregulated by Tiaozhi granules alcohol or water extracts in a dose-dependent manner. Pollen Typhae Angustifoliae alcohol extract with a high dosage could also increase SR-BI activity and expression, but not the extracts from Curcuma longa L. and Rhizoma Alismatis. Both Tiaozhi granule alcohol and water extracts can upregulate SR-BI gene expression. Among the components, Pollen Typhae Angustifoliae are important for the regulatory effect coordinating with Curcuma longa L. and Rhizoma Alismatis.

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Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: A review

Cited by 137 publications

References 99 publications

Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis

Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis

Geographic impact evaluation of the quality of Alismatis Rhizoma by untargeted metabolomics and quantitative assay

Effects of Extracts from Tiaozhi Granule and Its Components on Expression of Scavenger Receptor Class B Type I

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