Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): A review

Bi, Wu; Gao, Ying; Shen, Jie; He, Chunnian; Li, Haibo; Peng, Yong; Zhang, Chunhong; Xiao, Pei‐Gen

doi:10.1016/j.jep.2016.04.021

Cited by 101 publications

(123 citation statements)

References 135 publications

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“…More recently, extracts purified from these red maple plant parts are being investigated for their potential nutraceutical and cosmetic applications based on a wide range of biological properties including antioxidant, α‐glucosidase enzyme inhibitory, blood–glucose lowering, and skin lightening cosmetic effects . These biological effects have largely been attributed to the phenolic constituents found in the red maple species, in particular, anhydro‐1,5‐glucitol‐core containing gallotannins, which are only produced by certain members of the maple ( Acer ) genus in the entire higher plant kingdom . Our group has conducted extensive previous isolation and structure elucidation studies (by TOF‐MS and NMR spectroscopic data) of the leaves, flowers, twigs, and barks of the red maple species, which yielded a series of new compounds containing different numbers of galloyl substituents located at different positions on the anhydro‐1,5‐glucitol‐core .…”

Section: Introductionmentioning

confidence: 99%

Ultra‐fast liquid chromatography coupled with electrospray ionization time‐of‐flight mass spectrometry for the rapid phenolic profiling of red maple (Acer rubrum) leaves

Seeram

2018

J of Separation Science

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The red maple (Acer rubrum) species is economically important to North America because of its sap, which is used to produce maple syrup. In addition, various other red maple plant parts, including leaves, were used as a traditional medicine by the Native Americans. Currently, red maple leaves are being used for nutraceutical and cosmetic applications but there are no published analytical methods for comprehensive phytochemical characterization of this material. Herein, a rapid and sensitive method using liquid chromatography with electrospray ionization time-of-flight tandem mass spectrometry was developed to characterize the phenolics in a methanol extract of red maple leaves and a proprietary phenolic-enriched red maple leaves extract (Maplifa™). Time-of-flight mass spectrometry and tandem mass spectrometry experiments led to the identification of 106 phenolic compounds in red maples leaves with the vast majority of these compounds also detected in Maplifa™. The compounds included 68 gallotannins, 25 flavonoids, gallic acid, quinic acid, catechin, epicatechin, and nine other gallic acid derivatives among which 11 are potentially new and 75 are being reported from red maple for the first time. The developed method to characterize red maple leaves phenolics is rapid and highly sensitive and could aid in future standardization and quality control of this botanical ingredient.

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Section: Introductionmentioning

confidence: 99%

Ultra‐fast liquid chromatography coupled with electrospray ionization time‐of‐flight mass spectrometry for the rapid phenolic profiling of red maple (Acer rubrum) leaves

Seeram

2018

J of Separation Science

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“…The x log⁡ P scores of compounds 1 – 4 , as provided by PubChem, were all negative. Consistent with this tendency, the inhibitory activity of compound 7 , which possessed a 4′-hydroxyphenyl B-ring, was more potent than that of compound 6 , which possessed a 3′,4′-dihydroxyphenyl B-ring ( p < 0.05) (Table 1) [19]. Of particular note, trigalloyl-substituted tannins and kaempferol-derived flavonoids have been reported to reduce iNOS expression via NF-kB inactivation [23, 24].…”

Section: Resultsmentioning

confidence: 83%

“…Furthermore, ginnalin A-C from other Acer species [17, 18] has been reported to exhibit antihyperglycemic effects in a sucrose-loaded mouse model of diabetes. However, these previous studies used enzymatic tests or the acute glucose tolerance test, which are not sufficient to fully characterize the antidiabetic activity of AG [19]. The aim of this study was to isolate biological compounds from the leaves of AG and to evaluate the hypoglycemic activity of AG in a rat model of streptozotocin- (STZ-) induced diabetes.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative and Anti‐Inflammatory Activities of Galloyl Derivatives and Antidiabetic Activities of Acer ginnala

Park

Yoon

Yin

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Chromatographic isolation of the 80% MeOH extract of Acer ginnala (AG) yielded seven galloyl derivatives: gallic acid (1), ginnalin B (2), acertannin (3), maplexin D (4), maplexin E (5), quercetin-3-O-(2′′-galloyl)-α-L-rhamnopyranoside (6), and kaempferol-3-O-(2′′-galloyl)-α-L-rhamnopyranoside (7). This is the first study to report the isolation of compounds 4 and 5 from AG. Galloyl derivatives 3–7 exhibited potent radical scavenging activities, with 5 and 7 showing particularly strong inhibitory activities against nitric oxide production in lipopolysaccharides- (LPS-) stimulated RAW264.7 cells. In addition, oral administration of AG extract (500 mg/kg b.w.) improved symptoms of hyperglycemia and blunted the increases in serum GOT/GPT levels in a rat model of streptozotocin-induced diabetes. These results suggest that galloyl derivatives (1–7) are antioxidant and anti-inflammatory agents and that AG extract has potential as a functional material or novel herbal medicine for treating diabetes mellitus.

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“…Acer truncatum Bunge, a member of the Aceracae family, is endemic to China, Korea and Japan but is also found in Europe and North America [7] [8] The genus Acer (Aceraceae), commonly known as maple, comprises approximately 129 species that primarily grow in the northern hemisphere, especially in the temperate regions of East Asia, eastern North America, and Europe [9]. There have been many phytochemical investigations focusing on Acer truncatum, as this species has great commercial value and numerous applications in traditional Chinese medicine and drinks production.…”

Section: Introductionmentioning

confidence: 99%

Volatiles from <i>Acer truncatum</i> Flowers

Ren¹,

Si²,

Ye³

et al. 2018

AJPS

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Plant volatile organic compounds (Biogenic Volatile Organic compounds, referred BVOCs) have a significant impact on the atmospheric environment, air quality and human health. This experiment takes Acer truncatum flowers as the research object, uses solid-phase micro-extraction combine GC-MS (SPME-GC-MS) to detect the main component of volatiles released by the flowers from 10 individual trees of Acer truncatum (Acer truncatum Bunge). The results showed that 37 kinds of volatiles were detected and they are belonged to four types organic compouds, such as terpenoids, alcohols, ketones, esters.According to the analysis of the main components of Acer truncatum flower

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Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): A review

Cited by 101 publications

References 135 publications

Ultra‐fast liquid chromatography coupled with electrospray ionization time‐of‐flight mass spectrometry for the rapid phenolic profiling of red maple (Acer rubrum) leaves

Ultra‐fast liquid chromatography coupled with electrospray ionization time‐of‐flight mass spectrometry for the rapid phenolic profiling of red maple (Acer rubrum) leaves

Antioxidative and Anti‐Inflammatory Activities of Galloyl Derivatives and Antidiabetic Activities of Acer ginnala

Volatiles from <i>Acer truncatum</i> Flowers

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Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): A review

Cited by 101 publications

References 135 publications

Ultra‐fast liquid chromatography coupled with electrospray ionization time‐of‐flight mass spectrometry for the rapid phenolic profiling of red maple (Acer rubrum) leaves

Ultra‐fast liquid chromatography coupled with electrospray ionization time‐of‐flight mass spectrometry for the rapid phenolic profiling of red maple (Acer rubrum) leaves

Antioxidative and Anti‐Inflammatory Activities of Galloyl Derivatives and Antidiabetic Activities of Acer ginnala

Volatiles from &lt;i&gt;Acer truncatum&lt;/i&gt; Flowers

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Volatiles from <i>Acer truncatum</i> Flowers