Traditional uses, phytochemistry and pharmacological activity of Carpobrotus edulis: A global perspective

Mudimba, Toonse Nguwesu; Nguta, Joseph Mwanzia

doi:10.31254/phyto.2019.8305

Cited by 11 publications

(7 citation statements)

References 32 publications

(53 reference statements)

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“…Phenolic compounds have beneficial health-promoting properties and are regarded as the class of compounds mostly found in edible plants, fruits, and beverages among the phytochemicals [ 8 ]. They are effective in the treatments against several debilitating diseases such as cancer, diabetes, inflammation, pathogenic infections and aging, amongst others [ 9 , 10 ]. While some phenolics have demonstrated potential in the treatment and management of diabetes and its complications [ 11 ], an insight into deciphering the nature of interaction(s) with the implicated key enzymes is imperative to provide evidence-based data supporting their antidiabetic potential.…”

Section: Introductionmentioning

confidence: 99%

“…Carpobrotus edulis is locally referred to as Cape Fig (English), umgongozi (Zulu), perdevy, ghaukum, suurvy, ghoenavy, Hottentotsvy, Kaapsevy, rankvy, vyerank (Afrikaans) and is naturalized in Australia (west coast), England and some parts of the Mediterranean, though widely distributed within the capes of South Africa [ 13 ]. Juice from its leaves is ethnomedicinally used to treat dysentery, stomach cramps, sore throat, mouth infections, burns, bruises, scrapes, wounds, skin ailments (ringworm, dermatitis, eczema, sunburn, nappy rash herpes, cold sores, allergies) as well as tuberculosis (when mixed with either honey or olive oil) [ 10 , 13 ]. Besides its application in maintaining healthy pregnancy, formulations from the plant have also been reported to be therapeutic against diphtheria and diabetes [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Phenolics Profiling of Carpobrotus edulis (L.) N.E.Br. and Insights into Molecular Dynamics of Their Significance in Type 2 Diabetes Therapy and Its Retinopathy Complication

2021

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Adverse effects associated with synthetic drugs in diabetes therapy has prompted the search for novel natural lead compounds with little or no side effects. Effects of phenolic compounds from Carpobrotus edulis on carbohydrate-metabolizing enzymes through in vitro and in silico methods were assessed. Based on the half-maximal inhibitory concentrations (IC50), the phenolic extract of the plant had significant (p < 0.05) in vitro inhibitory effect on the specific activity of alpha-amylase (0.51 mg/mL), alpha-glucosidase (0.062 mg/mL) and aldose reductase (0.75 mg/mL), compared with the reference standards (0.55, 0.72 and 7.05 mg/mL, respectively). Molecular interactions established between the 11 phenolic compounds identifiable from the HPLC chromatogram of the extract and active site residues of the enzymes revealed higher binding affinity and more structural compactness with procyanidin (−69.834 ± 6.574 kcal/mol) and 1,3-dicaffeoxyl quinic acid (−42.630 ± 4.076 kcal/mol) as potential inhibitors of alpha-amylase and alpha-glucosidase, respectively, while isorhamnetin-3-O-rutinoside (−45.398 ± 4.568 kcal/mol) and luteolin-7-O-beta-d-glucoside (−45.102 ± 4.024 kcal/mol) for aldose reductase relative to respective reference standards. Put together, the findings are suggestive of the compounds as potential constituents of C. edulis phenolic extract responsible for the significant hypoglycemic effect in vitro; hence, they could be exploited in the development of novel therapeutic agents for type-2 diabetes and its retinopathy complication.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phenolics Profiling of Carpobrotus edulis (L.) N.E.Br. and Insights into Molecular Dynamics of Their Significance in Type 2 Diabetes Therapy and Its Retinopathy Complication

2021

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“…(Aizoaceae) is a mat-forming trailing succulent perennial that has been introduced into all continents, mostly growing in the Mediterranean regions [25]. This species is native from South Africa where it is used in traditional medicine for its several pharmacological applications for the treatment of tuberculosis and other respiratory infections, toothache and earache, facial eczema, wounds, burns, hypertension, and diabetes mellitus, due to the antimicrobial, antiproliferative, and antioxidant properties of C. edulis leaf extracts [26]. Despite its pharmacological potential, in the introduced range, this species impacts native communities by decreasing biodiversity and altering nutrient cycling dynamics [27,28].…”

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confidence: 99%

A rapid and sensitive method to assess seed longevity through accelerated aging in an invasive plant species

2020

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Background: Seed longevity and vigor assessment is crucial for efficient ex situ biodiversity conservation in genebanks but may also have potential applications for the understanding of ecological processes and in situ biodiversity conservation. In fact, one of the factors determining the persistence of invasive species, a main threat to global biodiversity, is the generation of soil seed banks where seeds may remain viable for several years. Artificial seed aging tests using high temperatures and high relative humidity have been described for seed longevity estimation but have been mainly optimized for species with commercial interest. Thus, the aim of the study is to define a rapid and sensitive method to assess seed longevity and vigor through accelerated aging in the worldwide distributed invasive species Carpobrotus edulis to provide tools to biodiversity managers to evaluate invasive potential and develop effective post-eradication plans. Results: Slow seed deterioration rate was obtained when C. edulis seeds were subjected to common accelerated aging temperatures (43-45 °C). This contrasts with the rapid viability decay between 24-72 h when seeds were subjected to temperatures superior to 55 °C, a strong inflection point for this species' thermosensitivity. Relative humidity also played a role in defining seed survival curves, but only at high temperatures, speeding up the deterioration process. The selected aging conditions, 55 °C at 87% relative humidity were tested over two C. edulis populations and three measures were proposed to parametrize the differential sigmoidal seed survival curves, defining the seed resistance to deterioration (L 5 , aging time where 95% of seeds maintain their viability), medium longevity (L 50 , 50% of seeds lose their viability) and lethal aging time (L 95 , 95% of viability loss). Conclusions: An accelerated aging test at 55 °C and 87% relative humidity constitutes a rapid and sensitive method that can be performed within a working week, allowing managers to easily test seed vigor and longevity. This test may contribute to assess invasive potential, design effective monitoring programs and soil seed bank eradication treatments.

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“…Different parts of this succulent have been used in traditional medicine across South Africa to treat a wide range of ailments, including microbial infections, tuberculosis, respiratory infections, skin problems, sore throat and mouth infection, HIV/AIDS, hypertension, and diabetes mellitus. [ 212 , 213 ]. The phytochemical analysis of different extracts of the peel and flesh of fruits of C. edulis showed the highest amounts of phenolic acids, flavonoids, and coumarins in peel extracts.…”

Section: Anticancer Effects and Cellular Targets Of Selected African ...mentioning

confidence: 99%

Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review

et al. 2023

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Africa is home to diverse medicinal plants that have been used for generations for the treatment of several different cancers and, presently, they are gaining interest from researchers as promising approaches to cancer treatment. This review aims to provide a comprehensive review of dietary and medicinal African fruits including their traditional uses, botanical description, ethnobotanical uses, bioactive phytochemical compositions, and anticancer properties investigated to date in vitro, in vivo, and in clinical studies. Data on recent updates concerning the traditional uses and anticancer properties of these fruits were collected from a myriad of available publications in electronic databases, such as Web of Science, PubMed, ScienceDirect, Scopus, SpringerLink, and Google Scholar. The results suggest that approximately 12 native or commercially grown African fruits belonging to different plant species, including Tribulus terrestris, Xanthium strumarium, Withania somnifera, Xylopia aethiopica, Abelmoschus esculentus, Carissa macrocarpa, Carpobrotus edulis, Syzygium cumini, Kigelia Africana, Annona muricata, Persea americana, and Punica granatum, have been reported for their potential as treatment options for the management of cancer. We further found that approximately eight different fruits from native plant species from Africa, namely, Sclerocarya birrea, Dovyalis caffra, Parinari curatellifolia, Mimusops caffra, Carpobrotus edulis, Vangueria infausta, Harpephyllum caffrum, and Carissa macrocarpa, have been widely used for the traditional treatment of different ailments but somehow failed to gain the interest of researchers for their use in anticancer research. In this review, we show the potential use of various fruits as anticancer agents, such as Tribulus terrestris, Xanthium strumarium, Withania somnifera, Xylopia aethiopica, Abelmoschus esculentus, Carissa macrocarpa, Carpobrotus edulis, Syzygium cumini, Kigelia Africana, Annona muricata, Persea americana, and Punica granatum; unfortunately, not enough reported research data have been published to gain thorough mechanistic insights and clinical applications. Additionally, we discuss the possibility of the utilization of potential phytochemicals from fruits like Persea americana and Punica granatum in anticancer research, as well as future directions.

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Traditional uses, phytochemistry and pharmacological activity of Carpobrotus edulis: A global perspective

Cited by 11 publications

References 32 publications

Phenolics Profiling of Carpobrotus edulis (L.) N.E.Br. and Insights into Molecular Dynamics of Their Significance in Type 2 Diabetes Therapy and Its Retinopathy Complication

Phenolics Profiling of Carpobrotus edulis (L.) N.E.Br. and Insights into Molecular Dynamics of Their Significance in Type 2 Diabetes Therapy and Its Retinopathy Complication

A rapid and sensitive method to assess seed longevity through accelerated aging in an invasive plant species

Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review

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