Traditional Uses of Pistacia lentiscus in Veterinary and Human Medicine

Landau, S.; Muklada, H.; Markovics, Alex; Azaizeh, Hassan

doi:10.1007/978-94-017-9276-9_8

Cited by 26 publications

(15 citation statements)

References 51 publications

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“…The sugar moieties were characterized based on the neutral losses of 132 (presence of pentosides: xylose or arabinose), 162 (hexosides: galactose or glucose), and 146 (deoxyhexoside: rhamnose). Thus, in agreement with the fragmentation patterns described in the literature [62,64] High contents of gallotannins (galloylquinic acid derivatives) and myricetin derivatives were previously described in P. letiscus leaves [6,7,9,17,68]. These compounds represent approximately 90% of the polyphenolic composition of the leaf extracts [6] and are possibly the main responsible for their biological properties such as: anti-inflammatory, cytoprotective, hepatoprotective, enzymatic-inhibitory, antitumor, and anti-diabetes [7,62,[69][70][71].…”

Section: Polyphenolic Composition Of the Richest P Lentiscus Extractsupporting

confidence: 85%

“…These The UV-Vis and MS/MS spectra allowed us to identify 19 compounds (Table 4), classified into three main classes: gallic acid derivatives (peaks 1 and 2), gallotannins (peaks 3-9), and flavonoids (peaks 10-19). For flavonoids, three peaks were identified as myricetin derivatives (peaks 10, 11, 14), six as quercetin derivatives (12,13,(15)(16)(17)(18), and one as a kaempferol derivative (19).…”

Section: Polyphenolic Composition Of the Richest P Lentiscus Extractmentioning

confidence: 99%

“…Plants 2020, 9, 1482 2 of 17 From a pharmacological point of view, both classes of phenolics have long been suggested to have high antioxidant capacities and other several biological activities [14]. Pistacia lentiscus leaves have traditionally been used in folk medicine for the treatment of various diseases such as hypertension, stomach aches, and kidney stones [15][16][17][18]. Moreover, anti-ulcer, anti-inflammatory, cytoprotective, acetylcholinesterase inhibition, and anticancer activities have been already described for its leaf extracts [15,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Optimization of a Green Ultrasound-Assisted Extraction of Different Polyphenols from Pistacia lentiscus L. Leaves Using a Response Surface Methodology

Detti

Nascimento

Brunetti

et al. 2020

Plants

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Pistacia lentiscus leaves are used in several applications, thanks to their polyphenolic abundance. Thiswork aimed to characterize the polyphenols and to optimize the extraction conditions to shorten the time, decrease the consumption of solvent, and to maximize the yield of different classes of phenolics, which have diverse industrial applications. The variables were optimized by applying a Box–Behnken design. Galloyl and myricetin derivatives were the most abundant compounds, and two new tetragalloyl derivatives were identified by LC-MS/MS. According to the models, the maximum yields of polyphenols (51.3 ± 1.8 mg g−1 DW) and tannins (40.2 ± 1.4 mg g−1 DW) were obtained using 0.12 L g−1 of 40% ethanol at 50 °C. The highest content of flavonoids (10.2 ± 0.8 mg g−1 DW) was obtained using 0.13 L g−1 of 50% ethanol at 50 °C, while 0.1 L g−1 of 30% ethanol at 30 °C resulted in higher amounts of myricitrin (2.6 ± 0.19 mg g−1 DW). Our optimized extraction decreased the ethanolic fraction by 25% and halved the time compared to other methods. These conditions can be applied differently to obtain P. lentiscus extracts richer in tannins or flavonoids, which might be employed for various purposes.

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Section: Polyphenolic Composition Of the Richest P Lentiscus Extractsupporting

confidence: 85%

Section: Polyphenolic Composition Of the Richest P Lentiscus Extractmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimization of a Green Ultrasound-Assisted Extraction of Different Polyphenols from Pistacia lentiscus L. Leaves Using a Response Surface Methodology

Detti

Nascimento

Brunetti

et al. 2020

Plants

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“…The use of plant extracts to mitigate inflammation has been known for thousands of years in human and veterinary medical practice 18 , and the Mediterranean evergreen Pistacia lentiscus (lentisk) is commonly used in traditional human and veterinary medicine 19 due to its antimicrobial and antimutagenic activity 20 , 21 , antioxidant capacity 22 , 23 , and anticancer 24 , 25 , antifungal and antiparasitic 19 properties. In dairy goats provided with P. lentiscus as a major source of forage, milk production and quality were much improved 26 , 27 .…”

Section: Introductionmentioning

confidence: 99%

Pistacia lentiscus extract enhances mammary epithelial cells’ productivity by modulating their oxidative status

Hadaya

Bransi-Nicola

Shalev

et al. 2020

Sci Rep

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We assessed the potential of phenolic compounds from Pistacia lentiscus (lentisk) to enhance production of milk constituents in bovine mammary epithelial cells (MEC). MEC were exposed to 0 (control), 1 or 10 ppm of polyphenols from lentisk ethanolic extract (PLEE) for 24 h. PLEE were absorbed by the MEC plasma membrane, but also penetrated the cell to accumulate in and around the nucleus. PLEE increased triglyceride content in the cell and its secretion to the medium, and significantly increased intracellular lipid droplet diameter. Compared to control, PLEE increased dose-dependently the lactose synthesis, secretion of whey proteins, and contents of casein. To evaluate mitochondrial activity under pro-oxidant load, MEC were preincubated with PLEE and exposed for 2 h to H2O2. Exposure to H2O2 increased the proportion of cells with impaired mitochondrial membrane potential twofold in controls, but not in PLEE-pre-treated cells. Accordingly, proton leakage was markedly decreased by PLEE, and coupling efficiency between the respiratory chain and ATP production was significantly enhanced. Thus, lentisk polyphenols divert energy to production of milk fat, protein and lactose, with less energy directed to cellular damage control; alternatively, PLEE enables MEC to maintain energy and oxidative status under extreme metabolic rate required for milk production and secretion, and reduces the limitation on energy required to support production.

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“…In Tunisia, a species of plant called Pistacia lentiscus L., commonly known as "Dharw" in the Maghreb and "Elustaka" in the Middle East, has medicinal properties in its oil extract. The extracted oil has numerous medicianal properties, for instance anti-atherogenic [2], anti-inflammatory [3][4][5], anti-oxidant [6][7][8][9][10], antimicrobial [9,[11][12][13], hypotensive [14,15], anticancer [5,16], anti-arthritis [17], wound treatment, and anti-asthmatic and anthelmintic activities [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Supercritical CO2 Extraction of Extracted Oil from Pistacia lentiscus L.: Mathematical Modeling, Economic Evaluation and Scale-Up

Aydi¹,

Zibetti

Al-Khazaal

et al. 2020

Molecules

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In this study, the extracted oil of Pistacia lentiscus L. the Tunis region was extracted using supercritical carbon dioxide (SC-CO2) extraction containing different major components in the oil such as α-pinene (32%) and terpinene-4-ol (13%). The investigation of the effect of different variables on the extraction yield with 5% level of confidence interval showed that the CO2 pressure was the main significant variable to influence the oil yield. In order to better understand the phenomena, three parameters were considered to adjust all parameters of broken and intact cell (BIC) model: grinding efficiency (G), the internal mass transfer parameter ( k S a 0 ), and the external mass transfer parameter ( k f a 0 ), which were estimated by experimental extraction curves to calculate the diffusion coefficient. From an economic point of view, we found out that the high cost of production of the extracted oil was due to the low mass of extracted oil obtained from this type of plant.

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Traditional Uses of Pistacia lentiscus in Veterinary and Human Medicine

Cited by 26 publications

References 51 publications

Optimization of a Green Ultrasound-Assisted Extraction of Different Polyphenols from Pistacia lentiscus L. Leaves Using a Response Surface Methodology

Optimization of a Green Ultrasound-Assisted Extraction of Different Polyphenols from Pistacia lentiscus L. Leaves Using a Response Surface Methodology

Pistacia lentiscus extract enhances mammary epithelial cells’ productivity by modulating their oxidative status

Supercritical CO2 Extraction of Extracted Oil from Pistacia lentiscus L.: Mathematical Modeling, Economic Evaluation and Scale-Up

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