Traditional use, phytochemistry, toxicology, and pharmacology of Origanum majorana L.

Bouyahya, Abdelhakim; Chamkhi, Imane; Benali, Taoufiq; Guaouguaou, Fatima-Ezzahrae; Balahbib, Abdelaali; Omari, Nasreddine El; Taha, Douae; Belmehdi, Omar; Ghokhan, Zenging; Menyiy, Naoual El

doi:10.1016/j.jep.2020.113318

Cited by 71 publications

(52 citation statements)

References 117 publications

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“…In recent years, many reviews appeared about phenolic profiles of plants and/or essential oils, evidencing anti-microbial, anti-bacterial [ 1 , 2 , 3 , 4 ], antioxidant [ 5 , 6 , 7 , 8 , 9 , 10 ], as well as pharmacological [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ] and nutritional [ 19 , 20 , 21 ] properties, together with a very informing book [ 22 ]. In view of their importance, studies were aimed at breeding plants able to increase the content of bioactive phenols [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Tailored Functionalization of Natural Phenols to Improve Biological Activity

et al. 2021

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Phenols are widespread in nature, being the major components of several plants and essential oils. Natural phenols’ anti-microbial, anti-bacterial, anti-oxidant, pharmacological and nutritional properties are, nowadays, well established. Hence, given their peculiar biological role, numerous studies are currently ongoing to overcome their limitations, as well as to enhance their activity. In this review, the functionalization of selected natural phenols is critically examined, mainly highlighting their improved bioactivity after the proper chemical transformations. In particular, functionalization of the most abundant naturally occurring monophenols, diphenols, lipidic phenols, phenolic acids, polyphenols and curcumin derivatives is explored.

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Section: Introductionmentioning

confidence: 99%

Tailored Functionalization of Natural Phenols to Improve Biological Activity

et al. 2021

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“…Extensive research has been conducted to understand the properties of essential oils, the structure–activity relationship (SAR) of constituents of essential oils, the mechanism of action, desirable and undesirable effects, etc. Various research studies have demonstrated that essential oils possess antibacterial, antifungal, and insecticidal properties [ 3 , 4 , 5 , 6 ]. Several in vitro studies have shown that phenolic compounds exhibit better antimicrobial activity compared to other components of essential oils [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of Novel Formulations Based on Terpenoid Prodrugs against C. albicans in a Mouse Model

et al. 2021

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Carvacrol (CAR), a phenolic monoterpenoid, has been extensively investigated for its antimicrobial and antifungal activity. As a result of its poor physicochemical properties, water soluble carvacrol prodrugs (WSCPs) with improved water solubility were previously synthesized and found to possess antimicrobial activity. Here, three novel CAR analogs, WSCP1, WSCP2, and WSCP3, were tested against fluconazole (FLU)-sensitive and -resistant strains where they showed greater antifungal activity than CAR against C. albicans. The probable mechanism by which the CAR prodrugs exert the antifungal activity was studied. Results from medium acidification assays demonstrated that the CAR and its synthetically designed prodrugs inhibit the yeast plasma membrane H+-ATPase (Pma1p), an essential target in fungi. In other words, in vitro data indicated that CAR analogs can prove to be a better alternative to CAR considering their improved water solubility. In addition, CAR and WSCP1 were developed into intravaginal formulations and administered at test doses of 50 mg/kg in a mouse model of vulvovaginal candidiasis (VVC). Whereas the CAR and WSCP1 formulations both exhibited antifungal efficacy in the mouse model of VVC, the WSCP1 formulation was superior to CAR, showing a remarkable decrease in infection by ~120-fold compared to the control (infected, untreated animals). Taken together, a synthetically designed prodrug of CAR, namely WSCP1, proved to be a possible solution for poorly water-soluble drugs, an inhibitor of an essential yeast pump in vitro and an effective and promising antifungal agent in vivo.

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“…Among the Eos, the one which is extracted from the Origanum majorana L. plant is one of the most promising due to its excellent antioxidant, antimicrobial, antifungal and antiparasitic properties and, consequently, high economic and industrial importance [ 10 , 11 ]. Origanum majorana L. belongs to the Lamiaceae family and is distributed in all of the Mediterranean region and Asia.…”

Section: Introductionmentioning

confidence: 99%

Effect of Deterpenated Origanum majorana L. Essential Oil on the Physicochemical and Biological Properties of Chitosan/β-Chitin Nanofibers Nanocomposite Films

et al. 2021

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Herein, the effect of three deterpenated fractions from Origanum majorana L. essential oil on the physicochemical, mechanical and biological properties of chitosan/β-chitin nanofibers-based nanocomposite films were investigated. In general, the incorporation of Origanum majorana L. original essential oil or its deterpenated fractions increases the opacity of the nanocomposite films and gives them a yellowish color. The water solubility decreases from 58% for chitosan/β-chitin nanofibers nanocomposite film to around 32% for the nanocomposite films modified with original essential oil or its deterpenated fractions. Regarding the thermal stability, no major changes were observed, and the mechanical properties decreased. Interestingly, data show differences on the biological properties of the materials depending on the incorporated deterpenated fraction of Origanum majorana L. essential oil. The nanocomposite films prepared with the deterpenated fractions with a high concentration of oxygenated terpene derivatives show the best antifungal activity against Aspergillus niger, with fungal growth inhibition of around 85.90%. Nonetheless, the only nanocomposite film that does not present cytotoxicity on the viability of L929 fibroblast cells after 48 and 72 h is the one prepared with the fraction presenting the higher terpenic hydrocarbon content (87.92%). These results suggest that the composition of the deterpenated fraction plays an important role in determining the biological properties of the nanocomposite films.

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Traditional use, phytochemistry, toxicology, and pharmacology of Origanum majorana L.

Cited by 71 publications

References 117 publications

Tailored Functionalization of Natural Phenols to Improve Biological Activity

Tailored Functionalization of Natural Phenols to Improve Biological Activity

Antifungal Activity of Novel Formulations Based on Terpenoid Prodrugs against C. albicans in a Mouse Model

Effect of Deterpenated Origanum majorana L. Essential Oil on the Physicochemical and Biological Properties of Chitosan/β-Chitin Nanofibers Nanocomposite Films

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