Traditional use of medicinal agents: a valid source of evidence

Helmstädter, Axel; Staiger, Christiane

doi:10.1016/j.drudis.2013.07.016

Cited by 55 publications

(39 citation statements)

References 18 publications

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“…Evidence-based phytotherapy is a complementary approach which can provide reliable research orientations by the valorisation of plants traditionally for a long time in the market for which bioactive principles or standardized extracts can be valorised with less risk of toxicity compared to classical HTS based on serendipity. The financial investments necessary to market a new chemical entity (NCE) are substantial and many pharmaceutical groups are relying on the historical, well known active principles on the traditional usage of medicinal agents which represents a valid and reputable source of evidence (Helmstädter and Staiger 2013).…”

Section: High-throughput Screening (Hts) Versus Evidenced-based Tradimentioning

confidence: 99%

The pharmaceutical industry and natural products: historical status and new trends

2014

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Section: High-throughput Screening (Hts) Versus Evidenced-based Tradimentioning

confidence: 99%

The pharmaceutical industry and natural products: historical status and new trends

2014

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“…Based Herbomineral Formulation used as holistic medicine for thousands of years, however the modern populations are dependent on various other forms like drugs, cosmetics, and agrochemicals [1]. These types of formulations also have been reported therapeutic benefits against different chronic diseases.…”

Section: Shirley Theresa Holmlundn Et Al: Skin Nourishing Effects Ofmentioning

confidence: 99%

Skin Nourishing Effects of Biofield Energy Healing Treatment Based Herbomineral Formulation

Holmlund¹,

Trivedi²,

Branton³

et al. 2017

EJPM

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Abstract:The aim of the present study was undertaken to evaluate the effects of a Consciousness Energy Healing (The Trivedi Effect ® ) Treatment based test formulation on skin health. The test formulation and DMEM were separated into two parts. One part of each received the Consciousness Energy Healing Treatment by Shirley Theresa Holmlund and were termed as the Biofield Energy Treated samples, while the other parts were considered as the untreated test samples. MTT assay showed more than 70% cells were viable in all the tested concentrations in three cell lines and that the test formulation was safe and nontoxic. The percent cell proliferation using BrdU assay was significantly increased by 343.57%, 100.29%, and 132.6% in the UT-DMEM + BT-Test formulation, BT-DMEM + UT-Test formulation, and BT-DMEM + BT-Test formulation groups, respectively at 8.75 µg/mL compared to the UT-DMEM + UT-Test formulation group. The collagen synthesis was significantly increased by 5.94% and 10.84% in the UT-DMEM + BT-Test formulation and BT-DMEM + BT-Test formulation groups, respectively at 0.625 µg/mL with respect to the untreated group. Elastin level was significantly (p≤0.001) increased by 15.95%, 58.31%, and 47.18% at 2.5 µg/mL in the UT-DMEM + BT-Test formulation, BT-DMEM + UT-Test formulation, and BT-DMEM + BT-Test formulation groups, respectively compared to the untreated group. The level of hyaluronic acid was significantly increased by 15.13% and 68.56% in the BT-DMEM + UT-Test formulation and BT-DMEM + BT-Test formulation groups, respectively at 0.625 µg/mL compared to the untreated group. The level of melanin was significantly reduced by 17.06%, 6.94%, and 13.07% in the UT-DMEM + BT-Test formulation, BT-DMEM + UT-Test formulation, and BT-DMEM + BT-Test formulation groups, respectively at 0.063 µg/mL compared to untreated group. The effect of skin protection upon exposure with UV-B rays displayed some alteration of the percent cell viability in all the tested groups. The wound healing activity by scratch assay exhibited significant wound closure and cell migration in the test formulation and DMEM in HFF-1 cells compared to the untreated group. Altogether, the data suggests that the Consciousness Energy Healing Treated DMEM and test formulation exhibited better skin protective responses compared to the untreated DMEM and test formulation group with respect to the skin health parameters. Therefore, the Biofield Energy Treated test formulation could be developed as a potential cosmetic product against various skin problems viz.

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“…50% cytotoxicity (302 nm, CL-1000 M, UVP, USA) [33]. The percent cell viability was assessed using formula equation (1).…”

Section: Anti-wrinkling Effects Of Test Formulation On Hff-1 Cells Agmentioning

confidence: 99%

“…It was found that approximately 30% of the worldwide drugs, cosmetics, and agrochemicals are based on the natural products [1], due to their significant mechanism in cellular, molecular, genetic, and biochemical pathways in various chronic diseases. In cosmetics and most of the skin care products, natural products are the principle active constituents [2].…”

Section: Introductionmentioning

confidence: 99%

Photo-Protective Effect of Biofield Energy Healing (The Trivedi Effect<sup>®</sup>) Treatment Based Herbomineral Formulation Against Various Skin Health Parameters

Hancharuk¹

2017

AJLS

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Abstract:The current study aimed to evaluate the effect of Biofield Energy Healing (The Trivedi Effect®) based herbomineral formulation on various skin health parameters. The test formulation consisted of minerals (zinc, selenate, and molybdenum), L-ascorbic acid, along with Centella asiatica extract, and tetrahydrocurcumin (THC). The test formulation and DMEM were divided into two parts, one part of each was treated with the Biofield Energy Treatment by Aksana Hancharuk and denoted as treated group, while other part was coded as the untreated groups. Skin parameters against various cell lines such as HFF-1, HaCaT and B16-F10 were examined with the combination of Biofield Treated (BT) and untreated test formulation (UT) with DMEM. MTT assay result showed that the test formulation was found to be safe and nontoxic at tested concentrations. Human fibroblast cell proliferation using BrdU method showed a significant increased cell proliferation by 91.51% and 201.14% in different Biofield Energy Treated groups. UT-DMEM + BT-Test formulation group showed an increased level of collagen by 64.58% (2.5 µg/mL) and 55.55% (1.25 µg/mL), respectively compared with the untreated group. Similarly, elastin synthesis was increased in UT-DMEM + BT-Test formulation group by 21.96% and 11.42% at concentration 10 and 5 µg/mL, respectively compared to the untreated group. However, hyaluronic acid level was increased by 14.02% and 6.57% at concentrations 1.25 and 0.625 µg/mL, respectively in BT-DMEM + BT-Test formulation group compared with the untreated group. Moreover, inhibition of melanin synthesis was observed by 12.95% and 17.86% (0.125 µg/mL) in UT-DMEM + BT-Test formulation and BT-DMEM + UT-Test formulation groups, respectively compared with the untreated group in B16-F10 melanoma cell line. Anti-wrinkling activity in HFF-1 cells showed a notable cell viability in all the groups at various concentrations, i.e. in UT-DMEM + BT-Test formulation, BT-DMEM + UT-Test formulation, and BT-DMEM + BTTest formulation group by 15.68%, 36.47%, and 29.64%, respectively at 2.5 µg/mL compared with the untreated group. The significant wound healing activity was reported in scratch assay in HFF-1 and HaCaT cells due to the significantly higher cellular migration of fibroblast and keratinocytes. Therefore, Biofield Energy Treatment (The Trivedi Effect ® ) based test formulation and cell medium might be a suitable approach for the development for herbal cosmetics and formulations as antiwrinkling, skin-whitening, anti-ageing, and rejuvenating action. It can improve the overall skin health care against many skin disorders such as Eczema, diaper rash, seborrheic dermatitis,

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Traditional use of medicinal agents: a valid source of evidence

Cited by 55 publications

References 18 publications

The pharmaceutical industry and natural products: historical status and new trends

The pharmaceutical industry and natural products: historical status and new trends

Skin Nourishing Effects of Biofield Energy Healing Treatment Based Herbomineral Formulation

Photo-Protective Effect of Biofield Energy Healing (The Trivedi Effect<sup>®</sup>) Treatment Based Herbomineral Formulation Against Various Skin Health Parameters

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Traditional use of medicinal agents: a valid source of evidence

Cited by 55 publications

References 18 publications

The pharmaceutical industry and natural products: historical status and new trends

The pharmaceutical industry and natural products: historical status and new trends

Skin Nourishing Effects of Biofield Energy Healing Treatment Based Herbomineral Formulation

Photo-Protective Effect of Biofield Energy Healing (The Trivedi Effect&lt;sup&gt;®&lt;/sup&gt;) Treatment Based Herbomineral Formulation Against Various Skin Health Parameters

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Product

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Photo-Protective Effect of Biofield Energy Healing (The Trivedi Effect<sup>®</sup>) Treatment Based Herbomineral Formulation Against Various Skin Health Parameters