Traditional treatment and community control of gastrointestinal helminthiasis in St Lucia, West Indies

Didier, J. M.; Bundy, D. A. P.; McKenzie, H. I.

doi:10.1016/0035-9203(88)90454-3

Cited by 8 publications

(3 citation statements)

References 1 publication

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“…Traditional system of healing from parasitic diseases has been in use with variable success since ancient times and some traditional potions are still used world wide (Dhar et al, 1968;Didier et al, 1988;Goto et al, 1990;Kar et al, 2004;Robinson et al, 1990;Singh et al, 1982;Soh et al, 1980). Lushai people in Mizoram, a north-east state of India, traditionally consume Millettia pachycarpa, a leguminous climbing plant, (Family: Leguminosae) to get rid of suspected intestinal helminth infections.…”

Section: Introductionmentioning

confidence: 97%

Ultrastructural observations on tegumental surface of Raillietina echinobothrida and its alterations caused by root‐peel extract of Millettia pachycarpa

Roy

Dasgupta

Tandon

2008

Microscopy Res & Technique

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Millettia pachycarpa Benth (Leguminosae) has a usage in traditional medicine system practiced among the Lushai tribes of Mizoram, a state in North East India, who customarily consume the aqueous extract of the root peel of the plant to get rid of intestinal worm infections. The crude ethanol, methanol, and acetone fractions of the plant were assayed against Raillietina echinobothrida, the intestinal cestode parasite of domestic fowl, to authenticate the putative anthelmintic efficacy and cestocidal potential in particular of the plants. In vitro exposure of the worm to the extract at a concentration of 25 mg/mL phosphate buffered saline (at 37 degrees C +/- 1 degrees C) revealed distortion and disruption of mitochondria, nucleus, nucleolus, nuclear membrane, basal lamina, and tegumental vacuolization in the distal cytoplasm leading to scar formation in the surface. The possible use of the plant as a potential anthelmintic against cestode parasite is discussed.

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Section: Introductionmentioning

confidence: 97%

Ultrastructural observations on tegumental surface of Raillietina echinobothrida and its alterations caused by root‐peel extract of Millettia pachycarpa

Roy

Dasgupta

Tandon

2008

Microscopy Res & Technique

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“…Plant products provide and are gaining importance as an alternative to current medical practices involving chemotherapy (Didier et al 1988;Robinson et al 1990). For many reasons, the latter may not be accessible to the masses in developing and underdeveloped countries.…”

Section: Introductionmentioning

confidence: 99%

Effect of root-tuber extract of Flemingia vestita , a leguminous plant, on Artyfechinostomum sufrartyfex and Fasciolopsis buski : a scanning electron microscopy study

Roy

Tandon

1996

Parasitology Research

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The tegumental surface of Artyfechinostomum sufrartyfex as viewed under the scanning electron microscope revealed the presence of double rows of spines in the collar. The dorsal surface (6-8 rows) and the ventral surface are provided with posteriorly directed spines. The normal body surface of Fasciolopsis buski shows posteriorly directed scales throughout the ventral surface; the dorsal surface is free of any scales but has domed, coarsely distributed papillae. When treated in vitro with ethanol root-tuber extract of Flemingia vestita, an indigenous medicinal plant in Meghalaya, India, at a concentration of 5, 10, and 20 mg/ml phosphate-buffered saline (PBS), A. sufrartyfex became paralyzed within 1.1-1.4, 0.8-1.0, and 0.3-0.5 h, respectively. Following similar treatment, F. buski took 3.0-3.6, 1.5-2.0, and 0.6-0.8 h, respectively, to reach a paralytic state. Oxyclozanide B.P. was used as the reference drug and paralyzed the worm, taking slightly less time than the crude extract for both species of flukes. Stereoscanning observations on the tegumental surface of treated (20 mg extract/ml PBS) A. sufrartyfex revealed sloughing off of most of the spines or their deformation as well as wrinkles and rupture of the general tegument. Severe tegumental alterations and deformities were also displayed by F. buski exposed to 20 mg extract/ml PBS.

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“…One mother said,`I start giving mastrus to my child when she is about 2 years of age if she is not eating well or if I see a worm in her faeces'. Herbal remedies are also commonly used against parasitic infections in Caribbean ® shing communities (Didier et al, 1988). A non-binomial distribution of helminth infection has important implications for the prediction of helminth-related morbidity.…”

Section: Resultsmentioning

confidence: 99%

Parasitic infections in villagers from districts of the Brazilian three Amazon

Thatcher¹

1998

Annals of Tropical Medicine And Parasitology

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A survey of intestinal parasites among 827 rural villagers in the Brazilian Amazon revealed that the prevalences of infection with Necator americanus, Trichuris trichiura and/or Ascaris lumbricoides were high. However, the intensities of infection with the two parasites for which there were enough data on intensity for further analysis, N. americanus and T. trichiura, were only low or moderate in each of the three districts studied. Possible reasons for the unusual (but not unique) absence of high intensities include moderately good sanitation, low population densities, the way in which work activities are located geographically, the use of indigenous anthelmintics and the geographical isolation of the communities which provided the subjects. Whether the light to moderate levels of infection observed require intervention is discussed.

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Traditional treatment and community control of gastrointestinal helminthiasis in St Lucia, West Indies

Cited by 8 publications

References 1 publication

Ultrastructural observations on tegumental surface of Raillietina echinobothrida and its alterations caused by root‐peel extract of Millettia pachycarpa

Ultrastructural observations on tegumental surface of Raillietina echinobothrida and its alterations caused by root‐peel extract of Millettia pachycarpa

Effect of root-tuber extract of Flemingia vestita , a leguminous plant, on Artyfechinostomum sufrartyfex and Fasciolopsis buski : a scanning electron microscopy study

Parasitic infections in villagers from districts of the Brazilian three Amazon

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