Traditional Tibetan medicine Anzhijinhua San attenuates ovalbumin-induced diarrhea by regulating the serotonin signaling system in mice

Xia, Zhenghuan; Zhang, Yifan; Xu, Yan; Dong, Jinjin; Wang, Lulu; He, Qiong; Zou, Xiaoyan; Wu, Huali; Han, Jichun; Cai, Minxuan; Du, Yuzhi; Wei, Lixin; Shang, Jing

doi:10.1016/j.jep.2019.01.020

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…The serum total IgE level is highly elevated in allergic patients such as bronchial asthma and is known to increase with the onset and aggravation of the disease (26,27). A specific IgE test is needed together with total IgE for proper evaluation of allergic diseases (28).…”

Section: Resultsmentioning

confidence: 99%

Pistacia weinmannifolia root exerts a protective role in ovalbumin‑induced lung inflammation in a mouse allergic asthma model

et al. 2019

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Pistacia weinmannifolia (Anacardiaceae) has been used in herbal medicine for the treatment of influenza, dysentery and enteritis in china. It was recently observed that P. weinmannifolia root extract (PWRE) exerts anti-inflammatory effects both in in vitro and in vivo models. Based on the results from previous studies, the present study investigated the protective effect of PWRE on airway inflammation and mucus hypersecretion. Treatment with PWRE significantly decreased the number of eosinophils and the levels of Th2 cytokines, such as interleukin (IL)-4, IL-5 and IL-13, in the bronchoalveolar lavage fluid (BALF) of OVA-exposed mice. PWRE decreased the high serum levels of total and OVA-specific immunoglobulin E. PWRE also effectively inhibited the influx of inflammatory cells into the lung, as well as airway mucus hypersecretion. In addition, the increased level of monocyte chemoattractant protein-1 was significantly decreased with the PWRE treatment in the BALF of OVA-exposed mice and in lipopolysaccharide-stimulated RAW264.7 macrophages. These protective effects of PWRE on OVA-induced pulmonary inflammation were accompanied by the downregulation of mitogen associated protein kinases and nuclear factor-κB activation. Thus, the results from the present study indicate that PWRE could be valuable adjuvant for the treatment of asthma.

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Section: Resultsmentioning

confidence: 99%

Pistacia weinmannifolia root exerts a protective role in ovalbumin‑induced lung inflammation in a mouse allergic asthma model

et al. 2019

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“…5-HT, as an important neurotransmitter of vomiting, exists widely in GI tract and nervous system [44,45]. Peripherally, 5-HT is predominantly stored and secreted by gastrointestinal chromaffin cells; in the center, 5-HT is mainly concentrated in the raphe nucleus, posterior region, solitary tract nucleus as well as dorsal vagal nucleus.…”

Section: Discussionmentioning

confidence: 99%

Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems

Tian

Qian

et al. 2019

J Nat Med

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Gingerol, a biologically active component in ginger, has shown antiemetic properties. Our study aimed to explore the underlying mechanisms of gingerol on protecting rats and minks from chemotherapy-induced nausea and vomiting. The preventive impact of gingerol was evaluated in the pica model of rats and the vomiting model of minks induced by cisplatin at every 6 h continuously for a duration of 72 h. Animals were arbitrarily separated into blank control group, simple gingerol control group, cisplatin control group, cisplatin + metoclopramide group, cisplatin + three different doses gingerol group (low-dose; middle-dose; high-dose). The area postrema as well as ileum damage were assessed using H&E stain. The levels of 5-TH, 5-HT3 receptor, TPH, SERT, SP, NK1 receptor, PPT, NEP, DA, D2R, TH, and DAT were determined using immunohistochemistry or qRT-PCR in rats and minks. All indicators were measured in the area postrema along with ileum. The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0–24-h and 24–72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks. Gingerol alleviates cisplatin-induced kaolin intake of rats and emesis of minks possibly by regulating central and peripheral 5-HT system, SP system and DA system. Graphic abstract

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“…In addition to the fecal bacteria refeeding method, the use of natural Chinese herbs to prevent and control piglet diarrhea has gained increasing attention [ 35 , 36 , 37 ]. Traditional Chinese herbal medicines, including Tibetan medicines, have been found to be effective in treating bacterial infectious diseases [ 38 ]. In this study, the addition of the Tibetan medicine fifteen-flavor black herbal pills to the diet reduced the frequency of diarrhea in the weaned Tibetan piglets compared with the Nor group.…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Feed Additives on Intestinal Metabolite Composition of Weaned Piglets

Zhao,

Zhang,

Liu

et al. 2024

Metabolites

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To study the effects of different feed additives on the weaning stress of Tibetan piglets, we selected 28 healthy, 30-day-old Tibetan weaned piglets and divided them into four groups, namely, the control group (basal feed without any antibiotic additions) (Nor), the group with the addition of the antibiotic lincomycin (Ant), the group with the addition of fifteen-flavor black pills of Tibetan medicine (Tib), and the group with the addition of fecal bacterial supernatant (Fec). We measured growth performance, blood physiological indexes, and metabolomics. The results showed that the Ant, Tib, and Fec groups significantly reduced the ratio of diarrhea to feed/weight (F/G) and increased the average daily gain (ADG) compared with the Nor group (p < 0.01). The Nor group had significantly lower leukocyte counts, hemoglobin levels, and erythrocyte counts compared with the other three groups at 21 d (p < 0.05). These physiological indexes tended to stabilize at 42 d. We found that there were beneficial metabolites and metabolic pathways for gastrointestinal function. Specifically, the porphyrin metabolic pathway was elevated in the Ant group, and the tryptophan metabolic pathway was significantly elevated in the Tib and Fec groups compared with the Nor group (p < 0.05). In conclusion, adding fecal bacterial supernatant and fifteen-flavor black pills of Tibetan medicine to the feed reduced the rate of diarrhea and improved the growth performance of the piglets. Moreover, it had an effect on the microorganisms and their metabolites and pathways in the gastrointestinal tract of the animals, which might be the main reason for influencing the diarrhea rate of weaned Tibetan piglets and the growth and development of the piglets. This study provides a new approach for anti-stress applications in weaned Tibetan piglets and the development of substitute anti-products.

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Traditional Tibetan medicine Anzhijinhua San attenuates ovalbumin-induced diarrhea by regulating the serotonin signaling system in mice

Cited by 7 publications

References 38 publications

Pistacia weinmannifolia root exerts a protective role in ovalbumin‑induced lung inflammation in a mouse allergic asthma model

Pistacia weinmannifolia root exerts a protective role in ovalbumin‑induced lung inflammation in a mouse allergic asthma model

Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems

Effects of Different Feed Additives on Intestinal Metabolite Composition of Weaned Piglets

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