Traditional systemic therapy I: methotrexate and cyclosporine

Prodanovic, Edward; Korman, Neil J.

doi:10.1007/978-3-7643-7724-3_7

Cited by 4 publications

(2 citation statements)

References 120 publications

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“…Like with methotrexate it was fortuitously found to clear psoriasis in patients being treated for severe longstanding rheumatoid arthritis [52]. In 1997 cyclosporine was FDA approved for the treatment of psoriasis [53].…”

Section: History Of the Therapy Of Psoriasismentioning

confidence: 99%

Lepra vulgaris. History of Psoriasis

Burg¹,

Geiges²

2014

J Turk Acad Dermatol

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Background: The history of psoriasis, remains highly speculative for the time before Willan (1757Willan ( -1812, and can be reliably assigned only for the last 200 years. Terms such as "Leprosy", "Impetigo" and "Psora" have been used in the centuries before. Hebra (1806-1880) gave a morphological and nosologic definition, in which also the histopathology appearance was taken into account. In the early 20th century, it was the biochemistry and histochemistry, which provided new insights. In the second half of the 20th century, immunocytochemistry and immunology shed some light on the pathogenetic processes of the disease. At the end of the 20th and at the beginning of the 21st century, it is the triumph of genetics and immunology, which have opened new therapeutic possibilities due to the interesting insights into the pathogenesis of psoriasis. However besides the new therapeutic modalities, which harbor some health and some economic threats, classical approaches still remain valuable tools. AbstractBackground: The history of psoriasis, remains highly speculative for the time before Willan (1757-1812), and can be reliably assigned only for the last 200 years. Terms such as "Leprosy", "Impetigo" and "Psora" have been used in the centuries before. Hebra (1806-1880) gave a morphological and nosologic definition, in which also the histopathology appearance was taken into account. In the early 20th century, it was the biochemistry and histochemistry, which provided new insights. In the second half of the 20th century, immunocytochemistry and immunology shed some light on the pathogenetic processes of the disease. At the end of the 20th and at the beginning of the 21st century, it is the triumph of genetics and immunology, which have opened new therapeutic possibilities due to the interesting insights into the pathogenesis of psoriasis. However besides the new therapeutic modalities, which harbor some health and some economic threats, classical approaches still remain valuable tools.

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Section: History Of the Therapy Of Psoriasismentioning

confidence: 99%

Lepra vulgaris. History of Psoriasis

Burg¹,

Geiges²

2014

J Turk Acad Dermatol

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“…The drug used in this work was CsA, which is a neutral cyclic polypeptide that is considered a powerful immunosuppressant and used in clinical practice in the prevention and treatment of rejection of organ transplants. For many years it was used as a drug of choice in the topical and systemic treatment of dermatological pathologies (psoriasis, atopic dermatitis, alopecia), of autoimmune ones (lupus), of rheumatoid arthritis and of autoimmune uveitis [ 27 , 28 ]. Recent studies have also demonstrated the possible antitumor activity of this molecule on different types of neoplastic cells [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Membranes Filled with Cyclosporine A as Possible Devices for Local Administration of Drugs in the Treatment of Breast Cancer

et al. 2021

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The aim of this work is the design, preparation and characterization of membranes based on cyclosporine A (CsA) and chitosan carboxylate (CC) to be used as an implantable subcutaneous medical device for a prolonged therapeutic effect in the treatment of breast cancer. The choice to use CsA is due to literature data that have demonstrated its possible antitumor activity on different types of neoplastic cells. To this end, CsA was bound to CC through an amidation reaction to obtain a prodrug to be dispersed in a chitosan-based polymeric membrane. The reaction intermediates and the final product were characterized by Fourier transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance (1H-NMR). Membranes were analyzed by differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The data obtained showed the effective formation of the amide bond between CsA and CC and the complete dispersion of CsA inside the polymeric membrane. Furthermore, preliminary tests, conducted on MDA-MB-231, a type of breast cancer cell line, have shown a high reduction in the proliferation of cancer cells. These results indicate the possibility of using the obtained membranes as an interesting strategy for the release of cyclosporin-A in breast cancer patients.

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