Traditional Medicine Policy and Regulation in Nigeria: An Index of Herbal Medicine Safety

Awodele, Olufunsho; Amagon, Kennedy I.; Wannang, Noel N.; Aguiyi, John Chinyere

doi:10.2174/1574886308666131126155434

Cited by 20 publications

(16 citation statements)

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“…36 An estimated 75% of the population still prefers to solve their health problems by consulting the traditional healers despite not yet integrated into the conventional healthcare system. 37 Many western countries have advanced in integrating the traditional medicine practices. [38][39][40] There is no doubt that traditional medicine remains important in meeting the health needs of the people despite expansion of orthodox medicine.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Adverse Drug Reaction Reporting Among Traditional Medicine Practitioners in Zaria Kaduna State Nigeria

Mohammed¹,

Umar²,

Labaran³

et al. 2019

TJNPR

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It is also common that the safety of most herbal products is further compromised by lack of suitable quality controls, inadequate labeling, and the absence of appropriate information. 7 The most common sources of information on adverse events and reactions to medicines are clinical trials and spontaneous reports. The latter ordinarily far exceed the former in numbers and type, especially serious reports, over the lifetime of a product. 8 Given the reality of global use of TMs, monitoring safety of such medicines becomes a priority for all stakeholders. Traditional medicines are not always safe, particularly when used in combination with other medicines. 5 An Adverse drug reaction (ADR) is defined as a response to a drug which is noxious and unintended, and which occurs at doses normally used in man for the prophylaxis, diagnosis, or therapy of disease, or for the modifications of physiological function. 6 Adverse drug reactions are a leading cause of morbidity and mortality globally. 9 It was reported that up to 20% of patients on drug therapy experience ADR. 10 It is therefore important that medication monitoring systems like pharmacovigilance (PV) are put in place to ensure safety. Pharmacovigilance is the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problem. 11 Reporting ADRs constitutes an integral part of PV process. Spontaneous reporting helps to detect serious and unusual adverse effects previously undetected during clinical trials. 10 In many countries, providers of herbal medicines other than physicians, dentists, pharmacists and nurses are excluded from reporting systems. 12 If adequate coverage of herbal medicines is to be achieved, national reporting schemes should be developed to include all

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Section: Resultsmentioning

confidence: 99%

Evaluation of Adverse Drug Reaction Reporting Among Traditional Medicine Practitioners in Zaria Kaduna State Nigeria

Mohammed¹,

Umar²,

Labaran³

et al. 2019

TJNPR

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show abstract

“…17 Awodele and his colleague have also echoed this call, asking for the development of national policies and regulations to ensure safety in use and create pathways towards the integration of traditional medicines in national health systems. 19 literature reveals that approximately 80% of the world's population utilises traditional healing system, this has subsequently stimulated increasing discussion on the need to regulate THPs. 8,9 This follows the promulgation of the Traditional Health Practitioners Act No.22 of 2007.…”

Section: Discussionmentioning

confidence: 99%

What is the nature of research conducted on regulating traditional health practitioners? A scoping review

Nzimande

Zuma

Moshabela

2021

Journal of Global Health Reports

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Background Widespread use of traditional medicine (TM), the issue of their safety, combined with progressive lobbying from both practitioner groups and the public have made regulation of traditional health practitioners (THPs) an important issue. While there are questions on whether the regulation of THPs are worthwhile endeavour, literature continues to offer limited empirical evidence for clear answers. It is essential to synthesize the available literature in relation to this quest using a scoping study methodology. Methods This scoping review included publications from PubMed, Sabinet and Web of Science databases and included grey literature, primary research, journal reviews, published reports, as well as available policy articles. A methodological framework set out by Arksey and O’Malley was utilized. Results Out of 8040 searched publications, 25 met the criteria for full review. Regulation of THPs proved essential, but ways of regulating them showed many inconsistencies and challenges. The issues of recognition, integration, and colonization effects and the idea of viewing TM through a scientific lens dominated the themes arising from the 25 publications. Conclusion Evidence depicted that regulating THPs would be an arduous task, but the existing literature proved insufficient on the use of such regulations. However, the review calls for more studies looking at THP regulatory mechanisms, especially in developing countries, to learn best practices that embrace indigenous knowledges and promote a decolonized health system.

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“…However, adverse and untoward fatal effects have been reported on plant such as, Parquetina nigrescens [9]. Toxicity associated with herbal products [10] [11] has alerted many national [12] and international regulatory authorities [13] to develop and implement various sets of guidelines for assessing, monitoring, and preventing the toxicity associated with such herbal products [14]. Toxicity tests are most widely used to examine specific adverse events or specific endpoints [15] irritation, etc.…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Toxicological Evaluations of Aqueous Extract of Parquetina nigrescens (Afzel.) leaves on Mifepristone-induced Polycystic Ovarian Syndrome in Rats

Femi-olabisi

Faokunla

Agboola

et al. 2020

J. Drug Delivery Ther.

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The biochemical and toxicological effects of aqueous extract of Parquetina nigrescens leaves (AEPNL) at the doses of 50, 100, and 200 mg/kg body weight on mifepristone-induced in Polycystic Ovarian Syndrome (PCOS) was investigated in female Wistar rats. Sixty female Wistar rats (190.00 ± 13.00 g) were assigned into 6 groups (A - F) of ten each: animals in group A received 0.5 ml of distilled water orally on daily basis for 30 days while the mifepristonized rats in groups B, C, D and E also received orally 0.5 ml of distilled water, 7.14mg/kg of metformin (reference drug) and same volume of the extract corresponding to 50, 100, and 200 mg/kg body weight of AEPNL respectively after which levels of some biochemical and toxicological indices were determined. AEPNL aggravated mifepristone-treatment related increases in albumin, total protein and liver aspartate aminotransferase activity and mitigated the increases in globulin, total bilirubin, urea, creatinine, liver and serum alkaline phosphatase and alanine aminotransferase activities, and no treatment-related histoarchitectural changes occurred in the liver, kidney and uterus of the female rats. Therefore, the aqueous extract of Parquetina nigrescens leaves attenuated and also aggravated some biochemical parameters in the serum, liver and kidney but with no histological changes in the liver, kidney and uterus of the mifepristonized female Wistar rats. Keywords: Mifepristone, toxicology, Parquetina nigrescens, Polycystic Ovarian Syndrome, histology

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Traditional Medicine Policy and Regulation in Nigeria: An Index of Herbal Medicine Safety

Cited by 20 publications

References 0 publications

Evaluation of Adverse Drug Reaction Reporting Among Traditional Medicine Practitioners in Zaria Kaduna State Nigeria

Evaluation of Adverse Drug Reaction Reporting Among Traditional Medicine Practitioners in Zaria Kaduna State Nigeria

What is the nature of research conducted on regulating traditional health practitioners? A scoping review

Biochemical and Toxicological Evaluations of Aqueous Extract of Parquetina nigrescens (Afzel.) leaves on Mifepristone-induced Polycystic Ovarian Syndrome in Rats

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