Traditional Medicinal Plants as a Source of Antituberculosis Drugs: A System Review

Abstract

Medicinal plants are the chief components in the different oriental formulations in different traditional medical systems worldwide. As a thriving source of medicine, the medicinal plants with antituberculosis (TB) properties inspire the pharmacists to develop new drugs based on their active components or semimetabolites. In the present review, the anti-TB medicinal plants were screened from the scientific literatures, based on the botanical classification and the anti-TB activity. The obtained anti-TB medicinal plants were categorized into three different categories, viz., 159 plants critically examined with a total 335 isolated compounds, 131 plants with their crude extracts showing anti-TB activity, and 27 plants in literature with the prescribed formula by the traditional healers. Our systemic analysis on the medicinal plants can assist the discovery of novel and more efficacious anti-TB drugs.

Herbal approach for tuberculosis management: A systematic review

“…TB spread from Eastern Africa to the entire world when Homo sapiens migrated from Eastern Africa to the world, especially over open supply routes with greater population mixing and overcrowding (19). Every year, nearly ten million new instances of active disease are identified, with over 1.3 million fatalities.…”

“…Over the lengthy period of combating this ancient plaque, several nations created their own traditional anti-TB medicines in accordance with its spreading route. Many of the TM medical system's ancient documents, including TCM, Ayurveda, and TAM, have TB data (19). This is owing to the TM clinical system's lengthy history of coexisting with humans for over 70,000 years.…”

“…This is owing to the TM clinical system's lengthy history of coexisting with humans for over 70,000 years. According to studies on TM formulations, the active molecules or semi-metabolites provide a plentiful basis of innovative medications (19).…”

“…Despite the fact that it is a government-sponsored programme with treatment and diagnostic services for free, many still flocks to private physicians when they have a symptom. According to investigations (19), 50-80 percent of TB patients seek treatment from private practitioners. Ayurvedic medications are currently not included in the RNTCP (3).…”

“…Rifampin every day for 4 months (4R) is much cheaper and much better efficient as compared to other therapies (QALY) excluding for isoniazid plus rifapentine once a week for 3 months (3HP) (19), which is active at a price of $ 49,000 per year (Holland et al, 2009). 3HP is additional rate effective than 9H at $20,207 per QALY.…”