Traditional Medicinal Plants

Karunamoorthi, Kaliyaperumal; Jegajeevanram, Kaliyaperumal; Vijayalakshmi, J.; Mengistie, Embialle

doi:10.1177/2156587212460241

Cited by 156 publications

(49 citation statements)

References 26 publications

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“…Taken together, botanical compounds have the advantage, over other synthetic drugs that they are generally recognized as safe, beneficial and are readily available resources, thus reducing the pricy steps needed for new drug discovery (Pan et al, 2013;Thomford et al, 2018). Furthermore, botanical-based remedies may be lowcost alternatives for unprivileged nations, if the botanicals are available, where access to modern medicine is difficult (Shaikh and Hatcher, 2005;Karunamoorthi et al, 2013). Botanical drugs also have the advantage, over standard small molecule drugs, that they have multiple bioactive compounds that may act synergistically to hamper virus replication, while avoiding antiviral resistance (Yuan et al, 2016;Chugh et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection

et al. 2020

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Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent within the human population and are characterized by lifelong infections and sporadic recurrences due to latent neuron infection. Upon reactivations, HSVs may manifest either, symptomatically or asymptomatically and be shed onto others through mucosae body fluids. Although, HSVs can produce severe disease in humans, such as lifethreatening encephalitis and blindness, the most common symptoms are skin and mucosal lesions in the oro-facial and the genital areas. Nucleoside analogs with antiviral activity can prevent severe HSV infection, yet they are not very effective for treating skin manifestations produced by these viruses, as they only reduce in a few days at most the duration of lesions. Additionally, HSV variants that are resistant to these antivirals may arise, especially in immunosuppressed individuals. Thus, new antivirals that can reduce the severity and duration of these cutaneous manifestations would certainly be welcome. Here, we review currently available anti-herpetic therapies, novel molecules being assessed in clinical trials and new botanical compounds reported in the last 20 years with antiviral activities against HSVs that might represent future treatments against these viruses.

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Section: Discussionmentioning

confidence: 99%

Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection

et al. 2020

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“…The variety of soils and climates in such countries facilitates the growth of a wide range of plants. Nevertheless, the native people use plants empirically, which had led to the lack of standards in their use in terms of effectiveness, safety, and quality [120]. This idea has triggered the worldwide development of drugs used in plants, which lead to the phytomedicine trade worldwide [118].…”

Section: Effects Of Medicinal Plants On Animal Models Of Painmentioning

confidence: 99%

Pharmaceutical and Botanical Management of Pain Associated with Psychopathology: A Narrative Review

Lozano¹,

Sánchez²,

Rodríguez³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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Generally, pain can be described as an unpleasant sensory or emotional experience associated with tissue damage. Chronic pain has become a public health problem because among 35 and 75% of the world population has shown the symptom. In particular, neuropathic pain has shown high comorbidity disorders such as anxiety and depression. Conventional therapies for treating pain include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, tricyclic antidepressants, anticonvulsants, and opioids, which usually cause some side effects such as gastritis, headache, liver and kidney toxicity, and drug dependence. Conventional pharmaceuticals also tend to be expensive, and they cannot be easily afforded in developing countries, which have led to the use of natural products as an alternative treatment. In this chapter, we reviewed the current research of natural products for pain treatment. We also describe preclinical studies that assess the effect of some natural products on pain therapy, phytochemistry research, toxicity, adverse effects, and biosecurity. We also describe how conventional pain is managed and the possible use of compounds obtained from vegetable species for pain treatment.

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“…At least 70% of the population of the developing world directly rely on traditional medicine for primary health care [29,30]. Equally, the industrialized nations indirectly rely on medicinal plants for their pharmaceutical products [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Asian Medicinal Plants’ Production and Utilization Potentials: A Review

2019

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Medicinal plants research in Asia continues to receive significant national and international attention, particularly concerning its multiple roles in poverty alleviation and health care support. However, scientific information on the institutional arrangements, the potentials of different medicinal plants production systems, and the utilization methods, remain highly fragmented. This incomprehensive information base shades the development of a comprehensive research agenda to improve the current body of knowledge, at least in the context of Asia. To address this impasse and propose future research perspectives, we systematically reviewed 247 journal articles, 15 institutional reports, and 28 book chapters. From the reviews, five key lessons are drawn: (i) Asian medicinal plant production systems demonstrate some dynamics, characterized by a gradual but continuous shift from wild gathering to cultivation, (ii) sub-regional variations exist with regards to the appreciation of medicinal plants potentials for traditional healing, modern healthcare and livelihoods support, (iii) knowledge on the effect of multi-scale institutional arrangements (formal and informal) on medicinal plant management practices is fragmented, (iv) very few studies dwell on the challenges of medicinal plants commercialization, particularly with regards to the role of middlemen, boom–bust cycle, raw material readiness, and product quality, and (v) law enforcement, benefit and knowledge sharing, and research and development should be prioritized to serve the interest of medicinal plants production actors. To further extend the body of knowledge on medicinal plants in Asia, we advance the need for empirical investigations on the performance of medicinal plants production systems and their contribution to livelihoods in diverse institutional contexts.

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Traditional Medicinal Plants

Cited by 156 publications

References 26 publications

Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection

Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection

Pharmaceutical and Botanical Management of Pain Associated with Psychopathology: A Narrative Review

Asian Medicinal Plants’ Production and Utilization Potentials: A Review

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