Traditional markers of excessive alcohol use

Conigrave, Katherine M.; Davies, Peter; Haber, Paul; Whitfield, John B.

doi:10.1046/j.1359-6357.2003.00581.x

Cited by 245 publications

(194 citation statements)

References 105 publications

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“…Since alcohol intake is associated with higher ADMA levels (27), g-glutamyltransferase was included in analyses being a marker of alcohol intake (28). We also found differences in g-glutamyltransferase between the ethnic groups ( Table 2 portrays the basic characteristics of the African and Caucasian men and women.…”

Section: African Men (Nz28)mentioning

confidence: 72%

Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians

Schutte¹,

Schutte²,

Huisman³

et al. 2010

European Journal of Endocrinology

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Objective: Alarming increases in hypertension and type 2 diabetes among Africans accentuate the need to identify factors that could serve as targets for prevention or treatment. In Caucasian populations, asymmetric dimethylarginine (ADMA), the predominant endogenous nitric oxide synthase inhibitor, is associated with cardiovascular disease and insulin resistance (IR). ADMA's counterpart, symmetric dimethylarginine (SDMA), originally thought to be inert, was recently also linked with cardiovascular risk. Since little information regarding ADMA or SDMA is available for Africans, our aim was to explore the relationships of ADMA and SDMA with measures of arterial stiffness and IR in Africans and Caucasians from South Africa. Methods: The study consisted of 235 nonsmoking, nondiabetic, nonobese, human immunodeficiency virus-uninfected Africans (nZ64) and Caucasians (nZ171), aged 20-70 years. We measured blood pressure, pulse wave velocity, ADMA, SDMA, and IR (homeostasis model assessment, HOMA). Results: African and Caucasian men had similar ADMA and SDMA, whereas Caucasian women had higher ADMA and SDMA than African women (P!0.05). African men and Caucasian women indicated strong correlations of ADMA with arterial stiffness (rZ0.47, PZ0.021; rZ0.26, PZ0.008), confirmed in multivariate analyses. Caucasian participants showed negative associations between SDMA and HOMA, being strongest in the men (rZK0.41; PZ0.002). Conclusion: Our results indicate that ADMA is independently associated with vascular dysfunction in African men and Caucasian women. A strong, independent negative association of SDMA with IR was found only in Caucasian participants. The molecular explanation for this is unclear, but these findings motivate experimental studies that could shed more light on these relationships.

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Section: African Men (Nz28)mentioning

confidence: 72%

Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians

Schutte¹,

Schutte²,

Huisman³

et al. 2010

European Journal of Endocrinology

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“…Gamma-glutamyl transferase levels above normal may be regarded as an indicator of alcohol over-consumption reaching pathophysiological effects [34]. This test is possibly more reliable than personal reporting of alcohol consumption.…”

Section: Psychosocial and Life Style Risk Factorsmentioning

confidence: 99%

Risk factors for hip fractures in a middle-aged population: a study of 33,000 men and women

et al. 2005

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“…Os biomarcadores de consumo de álcool mais utilizados são as enzimas hepáticas gamaglutamiltransferase (GGT), aspartato aminotransferase (AST) e alanino aminotransferase (ALT) e o volume corpuscular médio (VCM) 29 . Após a retirada do consumo alcoólico, os níveis séricos de GGT reduzem-se progressivamente, podendo voltar a valores normais dentro de dois meses de abstinência 30 .…”

Section: Discussionunclassified

Fatores de risco cardiovascular em alcoolistas em tratamento

Marliére

Nemer

2013

J. bras. psiquiatr.

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RESUMOObjetivo: Avaliar a presença de fatores de risco cardiovascular, com ênfase na hipertensão e na adiposidade corporal, em alcoolistas abstinentes ou não abstinentes em tratamento. ABSTRACTObjective: Evaluate cardiovascular risk factors, with emphasis on hypertension and adiposity, present in alcoholics abstinent or not abstinent. Method: This was a cross-sectional study with 65 alcoholic patients in treatment in CAPSad. The degree of alcohol dependence was assessed by SADD (Short Alcohol Dependence Data) and the use of other drugs by ASSIST (Alcohol Smoking and Substance Involvement Screening Test). We evaluated the biochemical and anthropometric profile users. Results: The study included 42 men and 23 women. The majority of the participants (67.74%) presented severe alcohol dependence with alcohol use mainly associated with smoking (66.15%). The average waist circumference (WC) was significantly higher among abstinent compared to non-abstinent (AB: 88.15 ± 15.95 x NA: 81.04 ± 9.86, p = 0.03). Patients longer abstinent had higher overweight/obesity and abdominal adi-

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Traditional markers of excessive alcohol use

Cited by 245 publications

References 105 publications

Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians

Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians

Risk factors for hip fractures in a middle-aged population: a study of 33,000 men and women

Fatores de risco cardiovascular em alcoolistas em tratamento

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