Traditional Korean Medicine as Collaborating Treatments with Conventional Treatments for Knee Osteoarthritis: A Protocol for a Systematic Review and Meta-Analysis

Park, Yeon-Cheol; Goo, Bonhyuk; Park, Kyeong-Ju; Kim, Junyeon; baek, yong hyeon

doi:10.2147/jpr.s311557

Cited by 4 publications

(6 citation statements)

References 19 publications

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“…The last decade of research demonstrated that the formula of TCM has promising potency for handling OA (Li & Zhang, 2020; Park et al, 2021). In their study, Peng et al showed that 5,7,3′,4′‐tetramethoxyflavone restored cholesterol dysregulation by mediating SIRT1/FOXO3a/ABCA1 signaling in OA‐affected chondrocytes (Peng et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rb1 from Panax ginseng attenuates monoiodoacetate‐induced osteoarthritis by inhibiting miR ‐21‐5p/ FGF18 ‐mediated inflammation

Luan

Che²,

et al. 2022

Journal of Food Biochemistry

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Osteoarthritis (OA) is a major degenerative disorder that affects the knee, and more than 33.6% of people aged over 65 years are affected by the disorder (O'Connor, 2006;Srikanth et al., 2005). The typical symptoms associated with OA include pain, swelling, stiffness, and loss of weight-bearing joint flexibility, all of which cast great burdens on patients' lives and the public health system. Currently, the most commonly used therapies for OA are those based on rehabilitation exercises and medication. However, these conventional therapies aim more at attenuating symptoms rather than providing curative treatment. Additionally, for patients with end-stage OA, joint replacement surgery is the only effective strategy, although the surgery itself comes with disadvantages such as high associated costs, perioperative complications, and infections (Gunaratne et al., 2017). Thus, the development of mild and effective methods of handling OA is highly solicited.

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Section: Discussionmentioning

confidence: 99%

Ginsenoside Rb1 from Panax ginseng attenuates monoiodoacetate‐induced osteoarthritis by inhibiting miR ‐21‐5p/ FGF18 ‐mediated inflammation

Luan

Che²,

et al. 2022

Journal of Food Biochemistry

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“…reviewregistry1086, http://www.researchregistry.com) and is published as a research paper. [19] This study is written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 checklist. [20]…”

Section: Methodsmentioning

confidence: 99%

Oriental medicine as collaborating treatments with conventional treatments for knee osteoarthritis: A PRISMA-compliant systematic review and meta-analysis

Park

Goo

et al. 2023

Medicine

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Background: We aimed to evaluate the effectiveness and safety of oriental medicine (OM) treatments as monotherapy and add-on therapy compared to conventional treatments for knee osteoarthritis and assess the quality of evidence for these results. OM treatment included acupuncture, herbal medicine, pharmacoacupuncture, and moxibustion. Methods: PubMed, Embase, Cochrane, Google Scholar, 4 Korean medical databases (KoreaMed, Korean Studies Information Service System, Research Information Service System, and Oriental Medicine Advanced Searching Integrated System), and one Chinese database (China National Knowledge Infrastructure) were searched for articles published between January 1, 2000, and January 1, 2021. Randomized controlled trials (RCTs) investigating the effect of OM interventions, single or combined with conventional treatments, on knee osteoarthritis were searched. The risk of bias and quality of evidence of the included studies were evaluated using the Cochrane Collaboration’s risk of bias tool and Grading of Recommendations, Assessment, Development, and Evaluation methods, respectively. Results: A total of 3911 relevant studies were retrieved and only 23 studies were included for systematic review. Most of the studies showed a significant effect on knee osteoarthritis. 21 studies comparing single OM treatment with conventional treatment were included in the meta-analysis. The effect size of standardized mean difference (SMD) was analyzed as a “small effect” with 0.48 (95% CI −0.80 to −0.16, Z = 2.98, P = .003). In addition, a meta-analysis of 4 studies comparing integrative treatment with conventional treatment showed a “very large effect” with 1.52 (95% CI −2.09 to −0.95, Z = 5.19, P < .001). Conclusion: Our results suggest that single OM treatment and integrative treatment significantly reduce pain in patients with knee osteoarthritis. However, there is a limited number of RCTs considering integrative treatment which implies more related RCTs should be conducted in the future.

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“…4. Traditional Chinese medicine treatment, such as Chinese medicine ointment, massage, acupuncture and moxibustion, which are mainly used to improve blood circulation ( Walsh et al, 2017 ; Zhang Z. et al, 2020 ; Park et al, 2021 ). 5.…”

Section: Introductionmentioning

confidence: 99%

Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases

Song

Shang

et al. 2021

Front. Cell Dev. Biol.

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When suffering from osteoarthritis (OA), articular cartilage homeostasis is out of balance and the living quality declines. The treatment of knee OA has always been an unsolved problem in the world. At present, symptomatic treatment is mainly adopted for OA. Drug therapy is mainly used to relieve pain symptoms, but often accompanied with adverse reactions; surgical treatment involves the problem of poor integration between the repaired or transplanted tissues and the natural cartilage, leading to the failure of repair. Biotherapy which aims to promote cartilage in situ regeneration and to restore endochondral homeostasis is expected to be an effective method for the prevention and treatment of OA. Disease-modifying osteoarthritis drugs (DMOADs) are intended for targeted treatment of OA. The DMOADs prevent excessive destruction of articular cartilage through anti-catabolism and stimulate tissue regeneration via excitoanabolic effects. Sprifermin (recombinant human FGF18, rhFGF18) is an effective DMOAD, which can not only promote the proliferation of articular chondrocyte and the synthesis of extracellular matrix, increase the thickness of cartilage in a dose-dependent manner, but also inhibit the activity of proteolytic enzymes and remarkedly slow down the degeneration of cartilage. This paper reviews the unique advantages of Sprifermin in repairing cartilage injury and improving cartilage homeostasis, aiming to provide an important strategy for the effective prevention and treatment of cartilage injury-related diseases.

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Traditional Korean Medicine as Collaborating Treatments with Conventional Treatments for Knee Osteoarthritis: A Protocol for a Systematic Review and Meta-Analysis

Cited by 4 publications

References 19 publications

Ginsenoside Rb1 from Panax ginseng attenuates monoiodoacetate‐induced osteoarthritis by inhibiting miR ‐21‐5p/ FGF18 ‐mediated inflammation

Ginsenoside Rb1 from Panax ginseng attenuates monoiodoacetate‐induced osteoarthritis by inhibiting miR ‐21‐5p/ FGF18 ‐mediated inflammation

Oriental medicine as collaborating treatments with conventional treatments for knee osteoarthritis: A PRISMA-compliant systematic review and meta-analysis

Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases

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