Traditional Japanese Medicine Daikenchuto Improves Functional Constipation in Poststroke Patients

Numata, Tomohiro; Takayama, Shin; Tobita, Muneshige; Ishida, Shuichi; Katayose, Dai; Shinkawa, Mitsutoshi; Oikawa, Takashi; Aonuma, Takanori; Kaneko, S.; Tanaka, Junichi; Kanemura, Seiki; Iwasaki, Katsunori; Ishii, Tadashi; Yaegashi, Nobuo

doi:10.1155/2014/231258

Cited by 34 publications

(34 citation statements)

References 37 publications

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“…Daikenchuto can be used to treat patients with pain or cold sensations in the abdomen, and those who cannot eat due to nausea. Numata et al (2014b) reported that daikenchuto alleviated functional constipation in post-stroke patients. A subscale analysis showed that daikenchuto significantly improved constipation scores.…”

Section: Functional Abdominal Pain or Constipationmentioning

confidence: 99%

Literature Review: Herbal Medicine Treatment after Large-Scale Disasters

et al. 2017

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Large-scale natural disasters, such as earthquakes, tsunamis, volcanic eruptions, and typhoons, occur worldwide. After the Great East Japan earthquake and tsunami, our medical support operation's experiences suggested that traditional medicine might be useful for treating the various symptoms of the survivors. However, little information is available regarding herbal medicine treatment in such situations. Considering that further disasters will occur, we performed a literature review and summarized the traditional medicine approaches for treatment after large-scale disasters. We searched PubMed and Cochrane Library for articles written in English, and Ichushi for those written in Japanese. Articles published before 31 March 2016 were included. Keywords "disaster" and "herbal medicine" were used in our search. Among studies involving herbal medicine after a disaster, we found two randomized controlled trials investigating post-traumatic stress disorder (PTSD), three retrospective investigations of trauma or common diseases, and seven case series or case reports of dizziness, pain, and psychosomatic symptoms. In conclusion, herbal medicine has been used to treat trauma, PTSD, and other symptoms after disasters. However, few articles have been published, likely due to the difficulty in designing high quality studies in such situations. Further study will be needed to clarify the usefulness of herbal medicine after disasters.

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Section: Functional Abdominal Pain or Constipationmentioning

confidence: 99%

Literature Review: Herbal Medicine Treatment after Large-Scale Disasters

et al. 2017

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“…[17][18][19][20] DKT significantly reduced gas volume and improved functional constipation in post stroke patients. 21 On the other hand, a study about female functional constipation patients indicated that there are no effect treatment with oral DKT on colonic transit, rectal sensation, and stool frequency. 22 Moreover, the 15 g/day dose was associated with lower rectal first sensation threshold and gas threshold.…”

Section: Introductionmentioning

confidence: 99%

Dai-Kenchu-To, a Herbal Medicine, Attenuates Colorectal Distention-induced Visceromotor Responses in Rats

Nakaya

Nagura

Hasegawa

et al. 2016

J Neurogastroenterol Motil

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Background/AimsDai-kenchu-to (DKT), a traditional Japanese herbal medicine, is known to increase gastrointestinal motility and improve ileal function. We tested our hypotheses that (1) pretreatment with DKT would block the colorectal distention-induced visceromotor response in rats, and (2) pretreatment with DKT would attenuate colorectal distention-induced adrenocorticotropic hormone (ACTH) release and anxiety-related behavior. MethodsRats were pretreated with vehicle or DKT (300 mg/kg/5 mL, per os). Visceromotor responses were analyzed using electromyography in response to colorectal distention (10,20, 40, 60, and 80 mmHg for 20 seconds at 3-minutes intervals). Anxiety-related behavior was measured during exposure to an elevated-plus maze after colorectal distention. Plasma ACTH and serum corticosterone levels were measured after exposure to the elevated-plus maze. ResultsColorectal distention produced robust contractions of the abdominal musculature, graded according to stimulus intensity, in vehicletreated rats. At 40, 60, and 80 mmHg of colorectal distention, the visceromotor responses of DKT-treated rats was significantly lower than that of vehicle-treated rats. At 80 mmHg, the amplitude was suppressed to approximately one-third in DKT-treated rats, compared with that in vehicle-treated rats. Smooth muscle compliance and the velocity of accommodation to 60 mmHg of stretching did not significantly differ between the vehicle-treated and DKT-treated rats. Similarly, the DKT did not influence colorectal distentioninduced ACTH release, corticosterone levels, or anxiety-related behavior in rats. ConclusionsOur results suggest that DKT attenuates the colorectal distention-induced visceromotor responses, without increasing smooth muscle compliance, ACTH release or anxiety-related behavior in rats.

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“…DKT is prescribed for abdominal pain with feeling cold and abdominal fullness. Clinical trials showed that DKT improves functional constipation in post-stroke patients (Numata et al 2014) and improves bowel movement after total gastrectomy for gastric cancer (Yoshikawa et al 2015). On the other hand, YKS is prescribed for neurosis, insomnia, and irritability in frailty.…”

Section: Discussionmentioning

confidence: 99%