Traditional herbal medicine for liver cancer: “Let’s pretend I like cooking and you pretend it tastes nice”

Philips, Cyriac Abby; Rajesh, S; John, S. K. P.; Valiathan, Gopakumar C.; Augustine, Philip

doi:10.1002/cncr.31707

Cited by 1 publication

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“…Complementary medicine is often used along with standard medical care, both when there is supportive evidence (eg, tai-chi to prevent falls in frail patients) and also when it is lacking (eg, yoga for epilepsy or herbal medicines for HCC). 1 , 2 Alternative medicine, which is used instead of standard medical therapy, has limited low-quality research attached in support of it (eg, dietary management of cancer instead of pharmacological therapy or homeopathic remedies for the prevention of COVID-19 instead of vaccination). 3 , 4 Complementary and alternative medical practices include biological therapies (herbs, minerals, and animal parts), mind-body therapies, manipulation-based body therapies, energy healing, and a combination of these.…”

Section: Introductionmentioning

confidence: 99%

Complementary and alternative medicines and liver disease

Philips,

Theruvath,

Ravindran

et al. 2024

Hepatology Communications

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Complementary and alternative medicines (CAM) include conventional medical treatments. Patients worldwide use CAM at alarming rates; thus, reports of CAM-related DILI have been on the rise. The clinical presentations include asymptomatic liver test abnormalities, acute hepatitis with or without jaundice, acute cholestatic liver disease (bland or with hepatitis), acute liver failure, severe hepatitis with features of portal hypertension, and acute decompensation of known or unknown cirrhosis that can lead to acute-on-chronic liver failure. Acute hepatitis with or without necrosis, hepatocellular and canalicular cholestasis, herb-induced or CAM-triggered autoimmune hepatitis, granulomatous hepatitis, severe steatohepatitis, and vanishing bile duct syndrome are common liver biopsy findings in CAM-DILI. The presence of preexisting liver disease predicts severe liver injury, risk of progression to liver failure, and decreased transplant-free survival in patients with CAM-DILI. This review discusses global epidemiology and trends in CAM-DILI, clinical presentation, assessment and outcomes, commonly emerging threats in the context of hepatotoxic herbs, pragmatic assessment of “liver beneficial” herbs and health care myths, patient communication, regulatory framework, and future directions on research in CAM.

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