Traditional herbal formula Sini Powder extract produces antidepressant-like effects through stress-related mechanisms in rats

Wei, Shanshan; He-jin, Yang; Huang, Jiawen; Lu, Xue‐Ping; Lingfang, Peng; Wang, Qingguo

doi:10.1016/s1875-5364(16)30069-3

Cited by 8 publications

(10 citation statements)

References 31 publications

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“…Examination of freezing as a fear response indicates that TMT elicits freezing to the same level as that induced by footshock (Wallace & Rosen, ). Previous studies have showed that TMT and elevated platform could elevate plasma corticosterone and induce heightened aggression (Dias Soares et al, ; Marquez et al, ; Papilloud et al, ; Wei et al, ), confirming their efficacy as robust stressors. After becoming adults, both male and female rats were then tested in the morphine‐induced CPP and locomotor activity tests to assess vulnerability to the rewarding and psychostimulant effect of morphine in adulthood (Garcia Pardo, Roger Sanchez, De la Rubia Orti, & Aguilar Calpe, ; Robinson & Berridge, ).…”

Section: Introductionmentioning

confidence: 77%

Peripubertal stress of male, but not female rats increases morphine‐induced conditioned place preference and locomotion in adulthood

Wang

Zhang

Huang

et al. 2019

Developmental Psychobiology

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Animal studies demonstrate that peripubertal social stress markedly increases the risk for subsequent substance use in adulthood. However, whether non‐social stress has a similar long‐term impact is not clear, and whether male and female animals show different sensitivity to peripubertal non‐social stress has not been examined. In the present study, we addressed these issues by introducing two non‐social stressors (elevated platform and predator odor 2,5‐Dihydro‐2,4,5‐trimethylthiazoline) to male and female Wistar rats during adolescence (postnatal days 28–30, 34, 36, 40, and 42), then tested reward‐related behaviors during adulthood, including morphine‐induced conditioned place preference (CPP, 1 mg/kg morphine or 5 mg/kg morphine) and hyperlocomotor activity (5 mg/kg morphine). We found that adult male rats, but not females who were exposed to peripubertal non‐social stressors showed enhanced morphine‐induced CPP. Moreover, morphine‐induced increase in locomotor activity was also significantly increased in adult male rats, but not in females. These results indicate that peripubertal exposure to repeated non‐social stress may enhance sensitivity to the rewarding effects of opioids in adulthood in a sex‐dependent manner, with males being even more sensitive than females in this regard.

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Section: Introductionmentioning

confidence: 77%

Peripubertal stress of male, but not female rats increases morphine‐induced conditioned place preference and locomotion in adulthood

Wang

Zhang

Huang

et al. 2019

Developmental Psychobiology

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“…The herbs were authenticated by our team. The SNS extract was prepared according to the previous article [34]. This extract contained flavonoid glycosides (56.36%) and saponins (12.067%), which were detected by UV.…”

Section: Methodsmentioning

confidence: 99%

Effect of traditional Chinese medicine formula Sinisan on chronic restraint stress-induced nonalcoholic fatty liver disease: a rat study

Cheng

Wang

et al. 2017

BMC Complement Altern Med

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BackgroundNonalcoholic fatty liver disease (NAFLD) represents one of the most common forms of liver disease worldwide, and it is always regarded as a consequence of a sedentary, food-abundant lifestyle, sitting for an extended time, and a low physical activity level, which often coincide with chronic and long-lasting psychological stress. A Chinese medicine Sinisan (SNS) may be a potential formula for treating this kind of disease.MethodsIn this study, a long-term chronic restraint stress protocol was used to investigate the mechanism underlying stress-induced NALFD. To investigate the effect of SNS treatment on stress-induced NAFLD, we measured the liver and serum values of total cholesterol (TC), triglyceride (TG), liver free fatty acids (FFA), low-density lipoprotein, superoxide dismutase, tumor necrosis factor-α, malondialdehyde, interleukin (IL)-6, and serum values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase. Results are shown as a mean ± standard deviation. Significant differences between the groups were evaluated using the Student t-test. For multiple comparisons, one-way analysis of variance (ANOVA) was used. If the results of ANOVA indicated significant differences, post hoc analysis was performed with the Tukey test or Dunnett test, and p < 0.05 was considered statistically significant.ResultsLong-term chronic stress led to steatosis and non-alcoholic steatohepatitis. Additionally, SNS treatment significantly increased body weight gain (p < 0.01) and sucrose preference (p < 0.001), and it reduced the liver values of TC, TG, and FFA (p < 0.05). SNS also reduced the serum values of AST and ALT (p < 0.001), and the liver value of IL-6 (p < 0.01).ConclusionsThis study’s results demonstrate that psychological stress may be a significant risk factor of NAFLD. Furthermore, the traditional Chinese medicine formula SNS may have some beneficial effect in antagonizing psychological stress and stress-related NAFLD.

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“…Animal experiments show that Chaihu Shugan powder can alleviate the depressive behavior of rats by increasing the expression of BDNF and TrkB in hippocampus, amygdala and frontal lobe (Zhan et al, 2004). Animal experiments show that Sinisan can reduce the increase of serum corticosterone and plasma ACTH by inhibiting the over activation of HPA axis, thus exerting the antidepressant effect (Wei et al, 2016). KXS is an effective treatment for mild and moderate depression.…”

Section: Discussionmentioning

confidence: 99%

Chinese Medicine Formula Kai-Xin-San Ameliorates Neuronal Inflammation of CUMS-Induced Depression-like Mice and Reduces the Expressions of Inflammatory Factors via Inhibiting TLR4/IKK/NF-κB Pathways on BV2 Cells

Liu

Cao

et al. 2021

Front. Pharmacol.

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Kai-Xin-San (KXS) is a traditional Chinese medicinal formula composed of Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria for relieving major depressive disorder and Alzheimer’s disease in traditional Chinese medicine (TCM) clinics. Previous studies on the antidepressant mechanism of KXS mainly focused on neurotransmitter and neurotrophic factor regulation, but few reports exist on neuronal inflammation regulation. In the current study, we found that KXS exerted antidepressant effects in chronic unpredictable mild stress-induced depression-like mice according to the results of behavioral tests. Meanwhile, KXS also inhibited the activation of microglia and significantly reduced the expression of pro-inflammatory cytokines such as IL-1β, IL−2, and TNF-α in the hippocampus of mice. In mice BV2 microglia cell lines, KXS extract reduced the expression of inflammatory factors in BV2 cells induced by lipopolysaccharide via inhibiting TLR4/IKK/NF-κB pathways, which was also validated by the treatment of signaling pathway inhibitors such as TAK-242 and JSH-23. T0hese data implied that the regulation of pro-inflammatory cytokines in microglia might account for the antidepressant effect of KXS, thereby providing more scientific information for the development of KXS as an alternative therapy for major depressive disorder.

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Traditional herbal formula Sini Powder extract produces antidepressant-like effects through stress-related mechanisms in rats

Cited by 8 publications

References 31 publications

Peripubertal stress of male, but not female rats increases morphine‐induced conditioned place preference and locomotion in adulthood

Peripubertal stress of male, but not female rats increases morphine‐induced conditioned place preference and locomotion in adulthood

Effect of traditional Chinese medicine formula Sinisan on chronic restraint stress-induced nonalcoholic fatty liver disease: a rat study

Chinese Medicine Formula Kai-Xin-San Ameliorates Neuronal Inflammation of CUMS-Induced Depression-like Mice and Reduces the Expressions of Inflammatory Factors via Inhibiting TLR4/IKK/NF-κB Pathways on BV2 Cells

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