Traditional eye medication and pterygium occurrence in Limpopo Province

Anguria, Peter; Ntuli, Sam; Interewicz, B; Carmichael, Trevor

doi:10.7196/samj.5930

Cited by 13 publications

(11 citation statements)

References 19 publications

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“…Most of the patients had participated in an earlier study that found heredity to be associated with pterygium occurrence. 12 Most of the recurrences occurred within three months after surgery, the majority of which were in young individuals, which is consistent with a previous report that observed that aggressive pterygia recurred within a short period after excision in young members of one family. 4 Pterygium progression may explain the varying recurrence times after surgery.…”

Section: 2supporting

confidence: 80%

“…The 200 patients comprised 120 who had participated in an earlier epidemiological study and 80 others who were interviewed and examined in the same way as those in the epidemiological study. 12 The indications for surgery were corneal astigmatism, obstruction or threatened obstruction of vision, disfigurement, or frequent inflammation. 13 No patient had received topical antiinflammatory treatment before surgery.…”

Section: Methodsmentioning

confidence: 99%

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Young patient’s age determines pterygium recurrence after surgery

2014

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Section: 2supporting

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Young patient’s age determines pterygium recurrence after surgery

2014

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“…Unlike our results, a study in Africa (Anguria et al, 2012) showed that cases of pterygium in the family can contribute to increasing the frequency of the disease in subsequent generations. Again, the discrepancy in results might be due to the different populations studied.…”

Section: Discussioncontrasting

confidence: 56%

“…Again, the discrepancy in results might be due to the different populations studied. The miscegenistic Brazilian population (Suarez-Kurtz et al, 2014) supports considerable genetic heterogeneity, whereas the African population studied was more homogeneous with respect to their genetic characteristics (Anguria et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil

et al. 2015

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ABSTRACT. The first reports about pterygium date back to Hippocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascularized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium, including heat, dust, and other particles in the atmosphere, and immunological mechanisms, mechanisms involving extracellular matrix reorganization, growth factors, cytokines, apoptosis, and angiogenesis. The aim of this study was to further investigate the association between polymorphisms in GSTM1 and the formation of pterygium. We collected peripheral blood samples from 90 patients diagnosed with pterygium and from 23 subjects without the disease in order to perform molecular analysis of the GSTM1 gene. Subjects with one or two copies of the GSTM1 allele had a normal genotype while those without any copies of the allele had a null genotype. The chi-square test or the Fisher exact test was performed in order to investigate possible associations between the molecular analysis and the risk of pterygium. A significant difference between the frequency of the GSTM1-null genotype in patient and control groups was identified. However, sub-group analysis found that the GSTM1-null genotype was statistically significant in men, but not in women, and in Caucasians, but not in Brown or Black groups. Furthermore, the GSTM1-null genotype was not related to any of the risk factors analyzed: cases in family, occupational exposure, smoking, hypertension, and diabetes.

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“…The control patients' selection criteria were similar to those of the pterygium cases. 15 The sections were marked and laid flat to facilitate orientation as previously reported. 7 One experienced histotechnologist processed the samples in a standard way.…”

Section: Methodsmentioning

confidence: 99%

Chronic inflammatory cells and damaged limbal cells in pterygium

Anguria

Carmichael²,

Ntuli³

et al. 2013

Afr H. Sci.

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Background: Chronic inflammation in pterygium occurrence has not been explained. Whether damaged limbal basal epithelial cells are associated with pterygium occurrence in black Africans is not clear. Objective: To explain chronic inflammation in pterygium, and to clarify whether damaged limbal basal epithelial cells were associated with pterygium occurrence in black Africans. Methods: Chronic inflammatory changes and damaged limbal basal epithelial cells were assessed in 59 samples. Results: Chronic inflammatory cells were present in 59 pterygia. Inflammatory cell count in 5 (27.8%) of 18 small pterygia was >200 (high) while in 22 (53.7%) of 41 large growths was <200 (low); p = 0.25. The proportion of pterygia with high counts tended to increase with pterygium extent. Twenty (33.9%) of 59 pterygia recurred after surgery. Ten (50%) of 20 samples had high cell counts and 10 (50%), low counts; p = 0.40. P53 expression was detected in 11 (18.6%) of 59 pterygium samples and 5 (71.4%) of 7 controls; p = 0.007. MMP 1 staining was present in 14 (23.7%) of 59 sections and 5 (71.4%) of 7 controls; p = 0.02. MMP2 in 16 (27.1%) cases and 5 (71.4%) controls; p = 0.03. MMP3 was overexpressed in 16 (27.1%) of 59 cases and 5 (71.4%) controls; p = 0.03. Conclusions: Mild chronic inflammation has a tendency to be more frequent than severe inflammation in pterygia. It is clear that damaged limbal basal epithelial cells are unlikely to be related to pterygium occurrence.

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Traditional eye medication and pterygium occurrence in Limpopo Province

Cited by 13 publications

References 19 publications

Young patient’s age determines pterygium recurrence after surgery

Young patient’s age determines pterygium recurrence after surgery

Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil

Chronic inflammatory cells and damaged limbal cells in pterygium

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