Traditional Eating Habits and Level of Homocysteine in the Acute First-Ever Ischaemic Stroke

doi:10.3889/mjms.1957-5773.2012.0231

Maced J Med Sci

2012

DOI: 10.3889/mjms.1957-5773.2012.0231

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Traditional Eating Habits and Level of Homocysteine in the Acute First-Ever Ischaemic Stroke

Abstract: Background: Meal with high-fat content represents a common and increasing habit in general population in the Macedonia. Contribution of homocysteine and meal with high-fat content in the acute phase of first-ever ischaemic stroke (AFIS) due to the different dietary habits remains unclear.

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2016

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Vascular Genetic Variants and Ischemic Stroke Susceptibility in Albanians from the Republic of Macedonia

Kamberi

Спироски³

2016

Open Access Maced J Med Sci

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BACKGROUND:Acute first-ever ischemic stroke (FIS) is a heterogeneous, polygenic disorder. The contribution of vascular genetic variants as inherited causes of ischemic stroke has remained controversial.AIM:To examine the association of genetic variants in vascular factors with the occurrence of FIS.MATERIAL AND METHODS:The current research was performed in a group of 39 patients with FIS (study group) and 102 healthy volunteers (control group). We analyzed the prevalence of vascular genetic variants in following genes: factor V, prothrombin, methylenetetrahydrofolate reductase (MTHFR), factor XIII, plasminogen activator 1, endothelial protein C receptor (EPCR), apolipoprotein B, apolipoprotein E, β-fibrinogen, human platelet antigen 1, angiotensin-converting enzyme (ACE), endothelial nitric oxide synthase (eNOS) and lymphotoxin alpha.RESULTS:It was found that heterozygous LTA 804C>A and FXIII V34L Leu/Leu were significantly more frequent in patients with FIS than in control group (p = 0.036 and p = 0.017, respectively). The frequency of FXIII V34L Val/Val was significantly lower in patients with FIS than in control group (p = 0.020). Other frequencies of vascular gene variants in patients with FIS and in control group were not significantly different.CONCLUSIONS:This is the first comprehensive study to present data indicating that polymorphism of vascular genes in the prevalence of acute FIS exists in the Albanian population from the Republic of Macedonia. Variations in these genes have been detected in patients with acute FIS, suggesting that their combination might act in a susceptible or protective manner in this Albanian population.

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Vascular Genetic Variants and Ischemic Stroke Susceptibility in Albanians from the Republic of Macedonia

Kamberi

Спироски³

2016

Open Access Maced J Med Sci

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Traditional Eating Habits and Level of Homocysteine in the Acute First-Ever Ischaemic Stroke

Abstract: Background: Meal with high-fat content represents a common and increasing habit in general population in the Macedonia. Contribution of homocysteine and meal with high-fat content in the acute phase of first-ever ischaemic stroke (AFIS) due to the different dietary habits remains unclear.

Cited by 1 publication

References 17 publications

Vascular Genetic Variants and Ischemic Stroke Susceptibility in Albanians from the Republic of Macedonia

Vascular Genetic Variants and Ischemic Stroke Susceptibility in Albanians from the Republic of Macedonia

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