Traditional, complementary, and alternative medicine: Focusing on research into traditional Tibetan medicine in China

Song, Peipei; Xia, Jufeng; Rezeng, Caidan; Li, Tong; Tang, Wei

doi:10.5582/bst.2016.01105

Cited by 9 publications

(8 citation statements)

References 51 publications

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“…Flavones have been used to prevent hypoglycemia, scavenge free radicals, inhibit the growth of tumors, and assist in bacteriostasis in traditional TM. Numerous traditional TMs, despite, have unknown active ingredients [ 3 ]. Myristica fragrans Houtt.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, some traditional TM may suggest promise in clinical treatments as plants, animals, trace elements, and minerals are the abundant sources used in such traditional medicines including biologically active substances and amino acids. Plants used are mostly cold and drought resistant, and they perform thorough photosynthesis [3]. Tibetan traditional medicines are being practiced more in the Himalayan region and are recommended by Amchis (Tibetan medicinal practitioners) in the northern belt of Nepal, the border of Tibet (autonomous region of China).…”

Section: Introductionmentioning

confidence: 99%

“…In TM, particular treatment is codified in the form of sacred texts or pharmacopeia elucidated with the Buddhist understanding of herbal remedies [ 2 ]. There are more than 20 different dosage forms in traditional TM such as pills, powders, decoctions, lotions, ointments, and medicinal liquors [ 3 ]. Dried raw materials are ground, mixed homogenously, and ultimately pressed into pills, powder, or decoctions.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Cytotoxic, and Antibacterial Activities of the Selected Tibetan Formulations Used in Gandaki Province, Nepal

Dhakal

Poudel

Jha

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background and Objective. Tibetan medicine is one of the earliest-known traditional medicines. This study aimed to evaluate the antioxidant, cytotoxic, and antibacterial potential of ethanolic extracts of nine common Tibetan formulations. Materials and Methods. An open-ended and semistructured questionnaire was used for an ethnomedicinal survey of the Tibetan formulations practiced in four Tibetan refugee settlements in Gandaki Province, Nepal. Based on the ethnomedicinal survey data, commonly used nine formulations were selected (Aru-18, Basam, Dadue, Dashel, Mutik-25, Raab Ga Yangzin Tea, Serdok-11, Sugmel-10, and Yungwa-4) to test biological activities. Antioxidant activity was evaluated using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging method. The cytotoxicity was examined by using the Allium cepa L. root tip meristem model. Similarly, the antibacterial effect was assessed by using well diffusion and broth dilution methods. Results. An ethnomedicinal survey showed a total of 52 Tibetan formulations were generally used by respondents for common diseases such as stomach disorders, diabetes, and migraine. From the antioxidant activity test, Sugmel-10 showed the highest DPPH free-radical-scavenging activity (IC50 1.8 μg/ml) and Yungwa-4 showed the lowest activity (IC50 5.2 μg/ml). Also, from the cytotoxic activity, the A. cepa root meristem model exhibited significant dose- and time-dependent growth suppression in Basam, Dadue, Mutik-25, and Serdok-11 as compared with cyclophosphamide standard drug. Similarly, Basam showed a good antibacterial effect having MIC 20 mg/ml and MBC 100 mg/ml against Enterococci faecalis. Conclusion. Research showed that Tibetan people preferred Tibetan formulations for the treatment and mitigation of several diseases. The result of antioxidant, cytotoxic, and antibacterial activities experimentally justified the ethnomedicinal value of nine common formulations (Aru-18, Basam, Dadue, Dashel, Mutik-25, Raab Ga Yangzin Tea, Serdok-11, Sugmel-10, and Yungwa-4). To the best of our knowledge, this study was performed for the first time in Nepal. Results from this preliminary study open the door to the scientific world to perform extensive pharmacological studies for designing and developing new therapeutic agents.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Cytotoxic, and Antibacterial Activities of the Selected Tibetan Formulations Used in Gandaki Province, Nepal

Dhakal

Poudel

Jha

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…In recent years, TMM has increasingly been accepted by more and more people worldwide, especially for the management of DM, and the researches for the anti-diabetic effects of TMM become increasingly popular ( Song et al, 2016 ). Here, we performed a large-scale text mining of PubMed and China National Knowledge Infrastructure (CNKI).…”

Section: Commonly Used Tibetan Materia Medica For Diabetes Mellitus Treatmentmentioning

confidence: 99%

Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives

et al. 2021

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Diabetes mellitus (DM) and its complications pose a major public health threat which is approaching epidemic proportions globally. Current drug options may not provide good efficacy and even cause serious adverse effects. Seeking safe and effective agents for DM treatment has been an area of intensive interest. As a healing system originating in Tibet, Traditional Tibetan Medicine (TTM) has been widely used by Tibetan people for the prevention and treatment of DM and its complications for hundreds of years. Tibetan Materia Medica (TMM) including the flower of Edgeworthia gardneri (Wall.) Meisn., Phyllanthi Fructus, Chebulae Fructus, Huidouba, and Berberidis Cortex are most frequently used and studied. These TMMs possess hypoglycemic, anti-insulin resistant, anti-glycation, lipid lowering, anti-inflammatory, and anti-oxidative effects. The underlying mechanisms of these actions may be related to their α-glucosidase inhibitory, insulin signaling promoting, PPARs-activating, gut microbiota modulation, islet β cell-preserving, and TNF-α signaling suppressive properties. This review presents a comprehensive overview of the mode and mechanisms of action of various active constituents, extracts, preparations, and formulas from TMM. The dynamic beneficial effects of the products prepared from TMM for the management of DM and its complications are summarized. These TMMs are valuable materia medica which have the potential to be developed as safe and effective anti-DM agents.

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Current status of research on endophytes of traditional Tibetan medicinal plant and their metabolites

Hu,

Long,

Luobu

et al. 2023

3 Biotech

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Traditional, complementary, and alternative medicine: Focusing on research into traditional Tibetan medicine in China

Cited by 9 publications

References 51 publications

Antioxidant, Cytotoxic, and Antibacterial Activities of the Selected Tibetan Formulations Used in Gandaki Province, Nepal

Antioxidant, Cytotoxic, and Antibacterial Activities of the Selected Tibetan Formulations Used in Gandaki Province, Nepal

Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives

Current status of research on endophytes of traditional Tibetan medicinal plant and their metabolites

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