Traditional Chinese medicine: potential for clinical treatment of rheumatoid arthritis

Moudgil, Kamal D.; Berman, Brian M.

doi:10.1586/1744666x.2014.917963

Cited by 61 publications

(35 citation statements)

References 22 publications

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“…Herbal products and acupuncture are the two most commonly used methods of TCM (Moudgil and Berman 2014). TCM is used in arthritis therapy based on traditional Chinese theories, the level of vital energy and other ancient criteria (Lu 2013).…”

Section: Introductionmentioning

confidence: 99%

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Zhong

Wang

Guo

et al. 2015

Tohoku J. Exp. Med.

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Juvenile idiopathic arthritis (JIA) is the most common arthritis in the adolescents under the age of 16. Etanercept, an inhibitor of tumor necrosis factor, is often used to treat JIA despite its significant side effects. Homeopathic remedies, such as blueberries, have anti-inflammatory properties with fewer unwanted effects and should be considered as a primary treatment. We aimed to explore the efficacy and safety of combination therapy of blueberry and etanercept for JIA. Two hundred and one JIA patients were selected, and randomly and evenly assigned to three groups: ETA (50 mg of etanercept twice weekly), ETABJ (matched etanercept and 50 ml blueberry juice daily) and ETAPJ (matched etanercept and placebo juice). The severity of JIA was measured using American College of Rheumatology scales (ACR) 20, 50 and 70. The levels of pro-inflammatory cytokines, interleukin-1 (IL1) alpha and IL1 beta, and interleukin-1 receptor antagonist (IL1RA) were measured by qRT-PCR and ELISA. After a 6-month follow-up, the ACR20, ACR50 and ACR70 in an ETABJ group were higher than those in other two groups (P < 0.05), suggesting clinically meaningful improvement in JIA. Meanwhile, the symptoms and side effects were reduced significantly or absent in an ETABJ group, including mental diseases, retrobulbar optic neuritis, gaining weight, infection, cutaneous vasculitis, diarrhea, uveitis and pancytopenia. Blueberries reduced the levels of IL1 alpha and beta, and increased the level of IL1RA. Thus, a combination therapy of blueberry and etanercept can reduce the severity of JIA and should be developed as a new method for JIA therapy.

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Section: Introductionmentioning

confidence: 99%

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Zhong

Wang

Guo

et al. 2015

Tohoku J. Exp. Med.

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“…(2) RA patients are watchfully waiting and hoping for novel remedies to lessen their suffering and economic burdens, and practitioners are hopeful that they will have available newer and better agents to ease the suffering of their patients. (3) Articles from multi-countries revealed the growing prevalence of integrative therapies used amongst patients with RA. (4) In China, a recent meta-analysis suggested that average annual per patient cost of herbal medicine (1769±3528 CNY) was close to disease modifying anti-rheumatic drugs (DMARDs, 1610±2138 CNY) of RA patients.…”

Section: Why Do Patients Seek Integrative Therapies?mentioning

confidence: 99%

Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations

Zhang

Jiang

et al. 2015

Chin. J. Integr. Med.

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Controlled clinical trials of integrative therapies available to patients with rheumatoid arthritis (RA) improved dramatically in the past 20 years, largely because of the growing need and the methodologies improvement. Tripterygium wilfordii Hook. F., a typical example of popular use herb, has been extensively studied in trials. However, clear and convincing evidence of integrative therapy, effectiveness and safety, remains insufficient to make decision. Many research efforts are hampered by standing problems with 'syndrome' recruitment failure. In addition, the outcome multiplicity induces the findings inefficiency to generalize to RA patients at large. Development of validated syndrome outcomes and methodologies has also been critical. Current efforts to enhance the understanding of integrative treatment options for patients with RA include the development of drug-specific rather than disease-specific strategies, studies in predictive biomarkers, and development of peer-review trial protocol for regular clinical trials.

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“…There is an increasing interest in the role of complementary and alternative medicine (CAM) in rheumatoid arthritis (RA) [1][2][3]. However, their application in routine care needs careful consideration of safety and reliability.…”

Section: Abstract Traditional Chinese Medicine · Complementary and Almentioning

confidence: 99%

Traditional Chinese medication for rheumatoid arthritis: more than what meets the eye

Santosa

Teng

2014

Rheumatol Int

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There is an increasing interest in the role of traditional Chinese medicine (TCM) in rheumatoid arthritis (RA), as evidenced by recent trials comparing their efficacy against established disease-modifying antirheumatic drugs. While the TCM in these trials seem to support a favorable cost-benefit ratio, many products are marketed under the guise of TCM, potentially exposing the user to unpredicted adverse events. We present the case of a patient with RA, who developed side effects from treatment with adulterated TCM. While TCM may be of value in the treatment of rheumatic diseases, their application in routine care continues to warrant careful consideration of safety and reliability.

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Traditional Chinese medicine: potential for clinical treatment of rheumatoid arthritis

Cited by 61 publications

References 22 publications

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations

Traditional Chinese medication for rheumatoid arthritis: more than what meets the eye

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