Traditional Chinese medicine of Salvia miltiorrhiza Bunge: a review of phytochemistry, pharmacology and pharmacokinetics

Nwafor, Ebuka-Olisaemeka; Lü, Peng; Li, Jiawei; Zhang, QingQing; Qi, Dongli; Liu, Zhidong; Peng, Hong-Li; Qin, Huan; Gao, Yanquan; Wang, JiLin

doi:10.53388/tmr20201027204

Cited by 9 publications

(4 citation statements)

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“…Moreover, Danshen is often made into various dosage forms for the treatment of cardiovascular and cerebrovascular diseases [ 4 ]. Up to now, more than 50 compounds from aqueous extracts and over 80 lipophilic compounds have been isolated from Danshen [ 5 ]. In addition, a large number of pharmacological studies showed that Danshen and its main components such as fat-soluble tanshinones (including tanshinone IIA, tanshinone I, cryptotanshinone, and dihydrotanshinone I, etc.)…”

Section: Introductionmentioning

confidence: 99%

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Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge)

Tang,

Zhao

2024

Molecules

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As one of the traditional Chinese herbs, Danshen (Salvia miltiorrhiza Bunge) has been widely studied and widely used in the treatment of cardiovascular, cerebrovascular, and other immune diseases. Tanshinones and salvianolic acids isolated from Danshen are considered to be the main components of its biological activity and pharmacology that play important roles in increasing the index of immune organs, regulating the number and function of immune cells, and releasing immunoreactive substances. Especially tanshinone IIA, cryptotanshinone, salvianolic acid B, and rosmarinic acid show good biological activity in treating rheumatoid arthritis, some immune-mediated inflammatory diseases, psoriasis, and inflammatory bowel disease. In order to understand their pharmacological effects and provide references for future research and clinical treatment, the regulation of immune response by tanshinones and salvianolic acids is summarized in detail in this paper. In addition, the challenges in their pharmacological development and the opportunities to exploit their clinical potential have been documented.

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Section: Introductionmentioning

confidence: 99%

“…and water-soluble salvianolic acids (including salvianolic acid A, salvianolic acid B, and rosmarinic acid, etc.) also exhibit other pharmacological activities such as anti-inflammatory, antioxidant, anti-tumor, and anti-fibrosis activity and modulation of the immune response [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge)

Tang,

Zhao

2024

Molecules

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“…The 2020 edition of the Chinese Pharmacopoeia records that Danshen can activate blood circulation, remove blood stasis, clear heat from the blood, and tranquilize the mind (National Pharmacopoeia Commission, 2020). Consequently, it has traditionally been used to treat various conditions such as cerebrovascular hemorrhage, edema, malignancies, menstrual abnormalities, miscarriages, and cardiovascular diseases (Nwafor et al, 2021). Modern studies have revealed that Danshen exhibits a wide range of complex pharmacological effects.…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis of Danshen combined with mesalazine for the treatment of ulcerative colitis

Zhang,

Xiong,

Liu

et al. 2024

Front. Pharmacol.

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Purpose: Current pharmacological treatments for Ulcerative Colitis (UC) have limitations. Therefore, it is important to elucidate any available alternative or complementary treatment, and Chinese herbal medicine shows the potential for such treatment. As a traditional Chinese herbal medicine, Danshen-related preparations have been reported to be beneficial for UC by improving coagulation function and inhibiting inflammatory responses. In spite of this, the credibility and safety of this practice are incomplete. Therefore, in order to investigate whether Danshen preparation (DSP) is effective and safe in the treatment of UC, we conducted a systematic review and meta-analysis.Methods: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database and CQVIP Database were searched for this review.The main observation indexes were the effect of DSP combined with mesalazine or DSP on the effective rate, platelet count (PLT), mean platelet volume (MPV) and C-reactive protein (CRP) of UC. The Cochrane risk of bias tool was used to assess the risk of bias. The selected studies were evaluated for quality and data processing using RevMan5.4 and Stata17.0 software.Results: A total of 37 studies were included. Among them, 26 clinical trials with 2426 patients were included and 11 animal experimental studies involving 208 animals were included. Meta-analysis results showed that compared with mesalazine alone, combined use of DSP can clearly improve the clinical effective rate (RR 0.86%, 95% CI:0.83–0.88, p < 0.00001) of UC. Furthermore it improved blood coagulation function by decreasing serum PLT and increasing MPV levels, and controlled inflammatory responses by reducing serum CRP, TNF-α, IL-6, and IL-8 levels in patients.Conclusion: Combining DSP with mesalazine for UC can enhance clinical efficacy. However, caution should be exercised in interpreting the results of this review due to its flaws, such as allocation concealment and uncertainty resulting from the blinding of the study.Systematic Review Registration: http://www.crd.york.ac.uk/PROSPERO/myprospero.php, identifier PROSPERO: CRD42022293287

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“…As shown in Figure 1 and Supplementary Figure S1, tanshinones are a group of active natural abietane diterpene ingredients isolated from the rhizome of Salvia miltiorrhiza Bunge (Danshen) [15,16], a famous traditional Chinese medicine for multiple therapeutic remedies [17]. Previous studies [18,19] indicated that there are more than ten monomers (Supplementary Figure S1), such as tanshinone I, tanshinone IIA, tanshinone II B, cryptotanshinone, and 1,2-dihydrotanshinquinone, in the rhizome of S. miltiorrhiza [15,20].…”

Section: Introductionmentioning

confidence: 99%

Dihydrotanshinone I Enhances Cell Adhesion and Inhibits Cell Migration in Osteosarcoma U−2 OS Cells through CD44 and Chemokine Signaling

et al. 2022

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In the screening of novel natural products against cancer using an in vitro cancer cell model, we recently found that tanshinones from a traditional Chinese medicine, the rhizome of Salvia miltiorrhiza Bunge (Danshen), had potent effects on cell proliferation and migration. Especially for human osteosarcoma U−2 OS cells, tanshinones significantly enhanced the cell adherence, implying a possible role in cell adhesion and cell migration inhibition. In this work, therefore, we aimed to provide a new insight into the possible molecule mechanisms of dihydrotanshinone I, which had the strongest effects on cell adhesion among several candidate tanshinones. RNA−sequencing-based transcriptome analysis and several biochemical experiments indicated that there were comprehensive signals involved in dihydrotanshinone I-treated U−2 OS cells, such as cell cycle, DNA replication, thermogenesis, tight junction, oxidative phosphorylation, adherens junction, and focal adhesion. First, dihydrotanshinone I could potently inhibit cell proliferation and induce cell cycle arrest in the G0/G1 phase by downregulating the expression of CDK4, CDK2, cyclin D1, and cyclin E1 and upregulating the expression of p21. Second, it could significantly enhance cell adhesion on cell plates and inhibit cell migration, involving the hyaluronan CD44−mediated CXCL8–PI3K/AKT–FOXO1, IL6–STAT3–P53, and EMT signaling pathways. Thus, the increased expression of CD44 and lengthened protrusions around the cell yielded a significant increase in cell adhesion. In summary, these results suggest that dihydrotanshinone I might be an interesting molecular therapy for enhancing human osteosarcoma U−2 OS cell adhesion and inhibiting cell migration and proliferation.

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Traditional Chinese medicine of Salvia miltiorrhiza Bunge: a review of phytochemistry, pharmacology and pharmacokinetics

Cited by 9 publications

References 0 publications

Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge)

Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge)

A systematic review and meta-analysis of Danshen combined with mesalazine for the treatment of ulcerative colitis

Dihydrotanshinone I Enhances Cell Adhesion and Inhibits Cell Migration in Osteosarcoma U−2 OS Cells through CD44 and Chemokine Signaling

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