Traditional Chinese medicine injections: where we are after 80-year development

Zheng, Wenwen; Wu, Yiyang; Gao, Hanlu; Ouyang, Defang

doi:10.1186/s13020-022-00681-w

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Among them, OCT2, MATE1/MATE2-K, OAT1/OAT3, OATP1B1/ OATP1B3, P-gp, and BCRP are recommended by the U. S. Food and Drug Administration (FDA) to investigate the potential DDIs in vitro [3]. TCMI is one of the modern preparation forms of TCM and has been widely used in clinical settings for detoxification, blood circulation promotion, and cancer treatment [4,5]. However, there is increasing concern about the ADRs of TCMIs, which account for more than 50 % of ADR reports of all TCMs [5].…”

Section: Introductionmentioning

confidence: 99%

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Potential Involvement of Organic Anion Transporters in Drug Interactions with Shuganning Injection, a Traditional Chinese Patent Medicine

Xing

Gui

et al. 2023

Planta Med

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Traditional Chinese medicine injections have been widely used in China for the treatment of various diseases. Transporter-mediated drug-drug interactions are a major contributor to adverse drug reactions. However, the research on transporter-mediated Traditional Chinese medicine injection-drug interactions is limited. Shuganning injection is a widely used Traditional Chinese medicine injection for treating various liver diseases. In this study, we investigated the inhibitory effect of Shuganning injection and its four main ingredients (baicalin, geniposide, chlorogenic acid, and oroxylin A) on 9 drug transporters. Shuganning injection strongly inhibited organic anion transporter 1 and organic anion transporter 3 with IC50 values < 0.1% (v/v), and moderately inhibited organic anion transporter 2, organic anion transporting-polypeptide 1B1, and organic anion transporting-polypeptide 1B3 with IC50 values < 1.0%. Baicalin, the most abundant bioactive ingredient in the Shuganning injection, was identified as both an inhibitor and substrate of organic anion transporter 1, organic anion transporter 3, and organic anion transporting-polypeptide 1B3. Oroxylin A had the potential to act as both an inhibitor and substrate of organic anion transporting-polypeptide 1B1 and organic anion transporting-polypeptide 1B3. In contrast, geniposide and chlorogenic acid had no significant inhibitory effect on drug transporters. Notably, Shuganning injection markedly altered the pharmacokinetics of furosemide and atorvastatin in rats. Using Shuganning injection as an example, our findings support the implementation of transporter-mediated Traditional Chinese medicine injection-drug interactions in the development of Traditional Chinese medicine injection standards.

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Section: Introductionmentioning

confidence: 99%

“…TCMI is one of the modern preparation forms of TCM and has been widely used in clinical settings for detoxification, blood circulation promotion, and cancer treatment 4 , 5 . However, there is increasing concern about the ADRs of TCMIs, which account for more than 50% of ADR reports of all TCMs 5 .…”

Section: Introductionmentioning

confidence: 99%