Traditional Chinese medicine injection for promoting blood circulation and removing blood stasis in treating angina pectoris of coronary heart disease

Abstract

Background: As a common cardiovascular disease, the morbidity and mortality of coronary heart disease (CHD) are increasing year by year. In recent years, many RCTs have proved that compared with conventional therapy, the combination of TCMIs for promoting blood circulation and removing blood stasis can improve clinical efficacy. However, there is still a lack of direct comparative study between different kinds of TCMIs. Therefore, based on the NMA, this study compares the curative effects of various TCMIs for promoting blood circulation and removing blood stasis in treating CHD to provide a reference for clinical medication. Methods: We will search PubMed, Web of Science, Embase, The Cochrane Library, China National Knowledge Infrastructure, The Chongqing VIP Chinese Science and Technology Periodic Database, Wanfang Database, and China Biomedical Literature Database for the randomized controlled trials of Danhong injection, Xuesaitong injection, Dengzhanxixin injection, and Salvianolate injection in the treatment of CHD, and we will also manually retrieve from the following databases: Chinese Clinical Trial Register, conference papers, and unpublished studies or references. According to the pre-established inclusion and exclusion criteria, 2 researchers independently screened the literature, extracted the data, and evaluated the RCTs’ quality. The primary outcome indicators are the total effective rate of improving angina pectoris symptoms and electrocardiogram improvement. Secondary indicators were angina pectoris attack frequency, angina pectoris attack time, hemorheology, and inflammatory factor level. And use Stata 16.0 software for mesh meta-analysis. Evidence will be checked using the classification of recommendation, evaluation, development, and evaluation. Results: In this study, from the perspective of different kinds of TCMIs for promoting blood circulation and removing blood stasis, we will compare the curative effects of varying treatment measures and rank the curative effects. Conclusion: This study will evaluate the efficacy of different kinds of TCMIs for promoting blood circulation and removing blood stasis in the treatment of CHD and help clinicians improve their clinical effectiveness. Unique INPLASY number: INPLASY202130103.

Study on the mechanism underlying Trichosanthis peel injection‐induced improvements in myocardial fibrosis markers in patients with chronic heart failure

“…It also has anti-platelet aggregation effects and protects the vascular endothelium. 20 Recent studies used Gualou Xiebai Banxia Decoction to treat 31 cases of chronic heart failure of coronary heart disease with phlegm rubidium-blocked qi stagnation and blood stasis, with satisfactory clinical efficacy and a total effective rate of 90.3%. 21 Another study treated 226 patients with stable angina pectoris and type-2 diabetes by trichosanthis peel injection and found that angina pectoris symptoms and hemorheology indices in the experimental group were significantly improved.…”

“…Modern pharmacological studies have shown that trichosanthis peel fructus extract can dilate coronary arteries, increase coronary blood flow, improve myocardial ischemia symptoms, reduce myocardial contractility, slow heart rate, reduce myocardial oxygen consumption and significantly reduce serum cholesterol, low‐density lipoprotein and triacylglycerol, thus playing a role in lowering blood lipids. It also has anti‐platelet aggregation effects and protects the vascular endothelium 20 . Recent studies used Gualou Xiebai Banxia Decoction to treat 31 cases of chronic heart failure of coronary heart disease with phlegm rubidium‐blocked qi stagnation and blood stasis, with satisfactory clinical efficacy and a total effective rate of 90.3% 21 .…”

Assessing Mailuoning injection in wound healing and thrombophlebitis management: A rat model study

“…Mailuoning injection, the composite traditional Chinese medicine preparation, has been clinically recognized for its ability to enhance blood flow, prevent clot formation, nourish yin, and dissipate heat 11,12 . It comprises a blend of potent ingredients including Achyranthes bidentata, honeysuckle, Radix Scrophulariae, and Dendrobium, each offering unique therapeutic benefits ranging from improving circulation and reducing inflammation to nourishing bodily fluids and alleviating pain 13 .…”

Salvia miltiorrhiza ameliorates endometritis in dairy cows by relieving inflammation, energy deficiency and blood stasis

“…The NEB can be determined using plasma thresholds of β-hydroxybutyrate, non-esterified fatty acids and glucose ( Macrae et al, 2019 ; Churakov et al, 2021 ). Additionally, blood stasis, defined by sub-optimal blood flow rather than by thrombosis ( Huang et al, 2021 ), happens broadly during female pregnancy and recovers spontaneously a few days after delivery. However, insufficient Qi to provide power for motion may result in continued postpartum blood stasis ( Li et al, 2014 ).…”