Traditional Chinese medicine for mild cognitive impairment

Abstract

Background: Mild cognitive impairment (MCI) is an intermediate stage between normal aging and Alzheimer disease, which is the most common form of dementia in the world. In clinical practice, traditional Chinese medicine (TCM) interventions have been administered for MCI, However, there is still uncertain about what strategy of TCM interventions treatment should be preferred in clinical practice. This study aims to evaluate the efficacy and acceptability of different TCM therapies through systematic review and network meta-analysis. Methods: According to the strategy, the authors will retrieve a total of 7 electronic databases by August 2020, including PubMed, the Cochrane Library, EMbase, China National Knowledge Infrastructure, China Biological Medicine, Chongqing VIP, and Wan-fang databases. After a series of screening, 2 researchers will use Aggregate Data Drug Information System and Stata software to analyze the data extracted from the randomized controlled trials of TCM therapies for MCI. The primary outcome of this study is the improvement of cognitive function and the secondary outcome is the activities of daily living, clinical efficacy, and adverse events, and the quality of the evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation instrument. Results: This study will provide a reliable evidence for the selection of TCM therapies in the treatment of MCI. Conclusion: This study will generate evidence for different TCM therapies for MCI and provide a decision-making reference for clinical research. Ethics and dissemination: This study does not require ethical approval. The results will be disseminated through a peer-reviewed publication. OSF registration number: DOI 10.17605/OSF.IO/JV9KG.

Neuroprotection of Rhizoma Polygonati on Mice with Cognitive Dysfunction Induced by D-Galactose

“…Alzheimer's Disease (AD), which is the most common dementia in the world (Wang et al, 2020). AD is a common neurodegenerative disease in the elderly and the major clinical manifestations are memory loss, learning disability and cognitive impairment (Zhang et al, 2019a).…”

Effects of gastrodin on the expression of brain aging‐related genes in SAM/P‐8 mice based on network pharmacology

“…Although aging cannot be stopped, it is possible to slow down the rate of aging through various methods. Traditional Chinese medicine (TCM) is receiving increasing attention in the prevention and treatment of various neurodegenerative diseases (NDs) caused by aging 8–12 . Studies have shown that TCM can improve the neurocholine function of the body, protect cerebral vessels, and significantly improve the cognitive function of patients by acting on multiple tissues and multiple targets 13,14 .…”

“…Traditional Chinese medicine (TCM) is receiving increasing attention in the prevention and treatment of various neurodegenerative diseases (NDs) caused by aging. 8 , 9 , 10 , 11 , 12 Studies have shown that TCM can improve the neurocholine function of the body, protect cerebral vessels, and significantly improve the cognitive function of patients by acting on multiple tissues and multiple targets. 13 , 14 Gastrodin is a phenolic glycoside isolated from the rhizome of Gastrodia elata and its tuber has been used in TCM for centuries.…”