Traditional Chinese Medicine for adjuvant treatment of breast cancer: Taohong Siwu Decoction

Jiang, Huajuan; Li, Minmin; Du, Kequn; Ma, Chuan; Cheng, Yanfen; Wang, Shengju; Nie, Xin; Fu, Chaomei; He, Yiyan

doi:10.1186/s13020-021-00539-7

Cited by 48 publications

(30 citation statements)

References 90 publications

(95 reference statements)

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“…The basis of the occurrence of malignant tumors is the weakness of vital qi, which is manifested in the low immune function. In TCM, the method of “Fuzheng cultivation” is adopted, which is to improve the immune function of the body by tonifying the innate kidney essence and the acquired spleen and stomach [ 19 ]. In the process of disease progression, patients often have deficiency syndromes such as spleen and stomach weakness, deficiency of qi and blood, depletion of yang qi, kidney failure, and deficiency of essence.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chinese Herbal Formula on Immune Function and Nutritional Status of Breast Cancer Patients

Liu

2022

Computational and Mathematical Methods in Medicine

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Background. Chinese herbal formulas have certain effects on patients with breast cancer (BC). This article discussed the effect of Buqi Yangxue decoction on the immune function and nutritional status of BC patients and provided an evidence for traditional Chinese medicine (TCM) to improve the quality of life and curative effect of BC patients. Methods. 66 cases of BC patients were divided into control group (n =33) and Chinese herbal formula group (n =33). The control group was received with TE chemotherapy, and the Chinese herbal formula group was received with Buqi Yangxue decoction combined with TE chemotherapy. Nutritional status, immune function, TCM symptom quantitative score, and adverse reactions were compared between the two groups. Results. There was no difference in all indexes between the two groups before intervention. After 4 weeks, the nutritional indexes ALB, PA, TRF, and TP in Chinese herbal formula group were higher than those in control group, except HGb. CD3+, CD4+, and CD4+/CD8+ in both groups were sharply higher than before treatment, while CD8+ was dramatically lower, and the changes in Chinese herbal formula group were more obvious than those in control group. In Chinese herbal formula group, the levels of IgG, IgA, and IgM were sharply increased compared with control group. The TCM syndrome scores in both groups were decreased significantly after treatment, especially in Chinese herbal formula group. In addition, nausea and vomiting, inappetence, liver function impairment, leukopenia, and thrombocytopenia occurred in both groups. There was no clear difference in the incidence of adverse reactions between Chinese herbal formula group and control group. Conclusion. Buqi Yangxue decoction can effectively improve the nutritional status and immune function of BC patients, which has important clinical significance for the later comprehensive treatment.

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Section: Discussionmentioning

confidence: 99%

Effects of Chinese Herbal Formula on Immune Function and Nutritional Status of Breast Cancer Patients

Liu

2022

Computational and Mathematical Methods in Medicine

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“…Traditional Chinese medicine exhibits various unique properties like varied active substances, multiple key targets, and low toxicity [39]. More importantly, it has superior antitumor properties and can be used to treat different tumors, such as esophageal cancer, liver cancer, pancreatic cancer, and breast cancer [40][41][42][43]. The present study identified the key active ingredients and possible detailed molecular mechanisms of Dahuang against hepatoma through network pharmacology, molecular docking, and survival analysis.…”

Section: Discussionmentioning

confidence: 93%

Investigating the Role of Dahuang in Hepatoma Treatment Using Network Pharmacology, Molecular Docking, and Survival Analysis

Wang

et al. 2022

BioMed Research International

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Hepatoma is one of the most common malignant tumors. The incidence rate is high in developing countries, and China has the most significant number of cases. Dahuang is a classic traditional antitumor drug commonly used in China and has also been applied to treat hepatoma. However, the potential mechanism of Dahuang in treating hepatoma is not clear. Therefore, this study is aimed at elucidating the possible molecular mechanism and key targets of Dahuang using methods of network pharmacology, molecular docking, and survival analysis. Firstly, the active ingredients and key targets of Dahuang were analyzed through public databases, and then the drug-ingredient-target-disease network diagram of Dahuang against hepatoma was constructed. Five main active components and five core targets were determined according to the enrichment degree. Enrichment analysis demonstrated that Dahuang treated hepatoma through the multiple pathways in cancer. Additionally, molecular docking predicted that aloe-emodin and PIK3CG depicted the best binding energy. Survival analysis indicated that a high/ESR1 gene expression had a relatively good prognosis for patients with hepatoma ( p < 0.05 ). In conclusion, the current study results demonstrated that Dahuang could treat hepatoma through a variety of active ingredients, targets, and multiantitumor pathways. Moreover, it effectively improved the prognosis of hepatoma patients. ESR1 is the potential key gene that is beneficial for the survival of hepatoma patients. Also, aloe-emodin and beta-sitosterol are the two main active crucial ingredients for hepatoma treatment. The study also provided some functional bases and references for the development of new drugs, target mining, and experimental animal research of hepatoma in the future.

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“…QD-BS causes poor blood circulation in tumors, which is similar to the hypercoagulable state of tumor patients found in modern medicine. The formation of tumor thrombi is closely related to abnormal coagulation during tumor progression ( 22 ). Due to the characteristics of promoting blood circulation and improving the hypoxic microenvironment, a variety of Chinese herb and formulas for SQ-ABC have become vital adjuvant treatments in treatment of tumor, such as HMMCR, Huayu pill ( 23 , 24 ), Taohong Siwu Decoction ( 25 ), and Qizhu decoction ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim–Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer

Zhang

et al. 2022

Front. Oncol.

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BackgroundHedysarum Multijugum Maxim–Curcumae Rhizoma (HMMCR), a well-known herb pair in traditional Chinese medicine (TCM), has been widely used for the treatment of various cancers. However, the active components of HMMCR and the underlying mechanism of HMMCR for non-small-cell lung carcinoma (NSCLC) remain unclear.MethodsActive ingredients of HMMCR were detected by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). On this basis, potential targets of HMMCR were obtained from SwissTargetPrediction database. NSCLC-related targets were collected from four public databases (GeneCards, OMIM, TTD, and PharmGkb). The drug ingredients–disease targets network was visualized. The hub targets between HMMCR and NSCLC were further analyzed by protein–protein interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Subsequently, the results predicted by network pharmacology were further validated via in vitro experiments.ResultsA total of 181 compounds were identified from the aqueous extract of HMMCR. Through network analysis, a compound–target network including 153 active ingredients of HMMCR and 756 HMMCR-NSCLC co-targets was conducted; 6 crucial compounds and 62 hub targets were further identified. The results of KEGG enrichment analysis showed that PI3K/Akt signaling pathway may be the critical pathway of HMMCR in the treatment of NSCLC. The in vitro experiments indicated that HMMCR inhibits the proliferation and migration of NSCLC cells via inactivation of the PI3K/Akt signaling pathway, consistent with the results predicted by network pharmacology.ConclusionIntegrating LC-ESI-MS/MS, network pharmacology approach, and in vitro experiments, this study shows that HMMCR has vital therapeutic effect on NSCLC through multi-compound, multi-target, and multi-pathway, which provides a rationale for using HMMCR for the treatment of NSCLC.

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Traditional Chinese Medicine for adjuvant treatment of breast cancer: Taohong Siwu Decoction

Cited by 48 publications

References 90 publications

Effects of Chinese Herbal Formula on Immune Function and Nutritional Status of Breast Cancer Patients

Effects of Chinese Herbal Formula on Immune Function and Nutritional Status of Breast Cancer Patients

Investigating the Role of Dahuang in Hepatoma Treatment Using Network Pharmacology, Molecular Docking, and Survival Analysis

Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim–Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer

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