Traditional Chinese medicine enhances myocardial metabolism during heart failure

Shao-Mei, Wang; Ye, Lifang; Wang, Lihong

doi:10.1016/j.biopha.2021.112538

Cited by 21 publications

(12 citation statements)

References 114 publications

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“…The primary six syndromes in heart failure patients are deficiency of Yang, Qi, blood stasis, fluid retention, Yin deficiency, and phlegm turbidity. 40 , 41 Deficiency of Qi and blood will cause tissue energy, urine, and bodily fluid to stagnate. 42 HQ, a tonic herb having ‘Gan flavour’ and ‘Wen nature’, is often used for benefiting ‘Qi’ and nourishing ‘blood’.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking

Chen,

Wang,

Sun

et al. 2024

J Cellular Molecular Medi

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Heart failure is a leading cause of death in the elderly. Traditional Chinese medicine, a verified alternative therapeutic regimen, has been used to treat heart failure, which is less expensive and has fewer adverse effects. In this study, a total of 15 active ingredients of Astragalus membranaceus (Huangqi, HQ) were obtained; among them, Isorhamnetin, Quercetin, Calycosin, Formononetin, and Kaempferol were found to be linked to heart failure. Ang II significantly enlarged the cell size of cardiomyocytes, which could be partially reduced by Quercetin, Isorhamnetin, Calycosin, Kaempferol, or Formononetin. Ang II significantly up‐regulated ANP, BNP, β‐MHC, and CTGF expressions, whereas Quercetin, Isorhamnetin, Calycosin, Kaempferol or Formononetin treatment partially downregulated ANP, BNP, β‐MHC and CTGF expressions. Five active ingredients of HQ attenuated inflammation in Ang II‐induced cardiomyocytes by inhibiting the levels of TNF‐α, IL‐1β, IL‐18 and IL‐6. Molecular docking shows Isorhamnetin, Quercetin, Calycosin, Formononetin and Kaempferol can bind with its target protein ESR1 in a good bond by intermolecular force. Quercetin, Calycosin, Kaempferol or Formononetin treatment promoted the expression levels of ESR1 and phosphorylated ESR1 in Ang II‐stimulated cardiomyocytes; however, Isorhamnetin treatment had no effect on ESR1 and phosphorylated ESR1 expression levels. In conclusion, our results comprehensively illustrated the bioactives, potential targets, and molecular mechanism of HQ against heart failure. Isorhamnetin, Quercetin, Calycosin, Formononetin and Kaempferol might be the primary active ingredients of HQ, dominating its cardioprotective effects against heart failure through regulating ESR1 expression, which provided a basis for the clinical application of HQ to regulate cardiac hypertrophy and heart failure.

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Section: Discussionmentioning

confidence: 99%

Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking

Chen,

Wang,

Sun

et al. 2024

J Cellular Molecular Medi

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show abstract

“…Traditional Chinese medicine typically exerts effects through antioxidative stress, anti-inflammatory actions, energy metabolism regulation, ventricular remodeling improvement, myocardial fibrosis reduction, and angiogenesis promotion [ 28 , 29 , 30 ]. Consequently, numerous traditional Chinese medicine preparations have emerged as treatments for heart failure, including Shengmai Drink, Yixinshu Capsules, Qili Qiangxin Capsules, and Nuanxin Capsule [ 31 , 32 , 33 ]. These illustrate the growing diversification and sophistication of heart failure treatment modalities.…”

Section: Introductionmentioning

confidence: 99%

Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure

Ma,

Li,

et al. 2024

Pharmaceuticals

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Gardenia is both a food and medicine plant. It is widely used for cardiovascular protection, and its main bioactive ingredient is crocetin. This study aims to observe the therapeutic effects of crocetin on chronic heart failure in rats induced by various etiologies. It further compares the efficacy differences between preventative and treatment administration, varying dosages, and treatment durations, to provide improved guidance for medication in heart failure rats and determine which categories of chronic heart failure rats might benefit most from crocetin. Chronic heart failure models induced by abdominal aorta constriction, renal hypertension, and coronary artery ligation were constructed. By examining cardiac function, blood biochemistry, and histopathology, the study assessed the preventive and therapeutic effects of crocetin on load-induced and myocardial ischemia-induced heart failure. The results showed that in all three models, both treatment and preventative administration of crocetin significantly improved chronic heart failure in rats, especially in preventative administration. The results indicate crocetin may be beneficial for improving symptoms and functional capacity in rats with heart failure. Furthermore, long-term administration was more effective than short-term administration across all three rat models, with therapeutic onset observed over 6 weeks.

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“…The natural products contain a variety of active ingredients such as alkaloid, glycoside, flavone and polyphenol etc , which exhibit diverse biological activities with the potential therapeutic value for HF [ 25 , 26 ]. Moreover, the natural products have the comprehensive advantages of high affinity, multi-target and multi-pathway that can avoid the single target induced various compensatory adverse reactions, as well as preventing the reduced pharmacological effects caused by the drug metabolism [ 27 , 28 ]. The representative natural products such as flavonoid, saponin, phenolic acid, alkaloid and polysaccharide have the effects of enhancing myocardial contractility, dilating blood vessels, diuresis and reducing myocardial remodeling, and the other biological activities including anti-fibrosis, anti-inflammation and anti-oxidative stress also contribute to HF therapy [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

The recent advance and prospect of natural source compounds for the treatment of heart failure

Chen,

Liu,

et al. 2024

Heliyon

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Traditional Chinese medicine enhances myocardial metabolism during heart failure

Cited by 21 publications

References 114 publications

Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking

Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking

Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure

The recent advance and prospect of natural source compounds for the treatment of heart failure

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