Traditional Chinese medicine compounds ameliorating glomerular diseases via autophagy: A mechanism review

Shi, Xiujie; Chang, Mei-Ying; Zhao, Mingming; Shi, Yue

doi:10.1016/j.biopha.2022.113916

Cited by 8 publications

(4 citation statements)

References 134 publications

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“…Hal tersebut diduga disebabkan pemberian ekstrak etanol daun mimba dengan dosis 14 mg/ kg BB masih aman dikonsumsi. Shi et al (2022) Ekstraksi bahan uji dalam penelitian ini menggunakan pelarut etanol. Utami dan Putri (2020) menyatakan bahwa etanol adalah pelarut dengan indeks polaritas 5,2.…”

Section: Hasil Dan Pembahasanunclassified

Safety Test for Ethanolic Neem Leaf (Azadirachta indica A. Juss.) Extract on Male Mice (Mus musculus L) Renal Structure

Lestari,

Sitasiwi,

Isdadiyanto

2023

Jurnal Sain Veteriner

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Neem leaves (Azadirachta indica A. Juss.) are often used as traditional medicine because they contain bioactive compounds such as azadirachtin, nimbidin and nimbolides. Consumption of traditional medicines for long periods can cause side effect on kidney. This study aims to find out the histological structure of glomerular and proximal tubular in the male mice (Mus musculus L.) kidneys after exposure to the ethanolic of neem leaves extract. Completely Randomized Design (CRD) consists of 2 treatment groups with 15 replications was used in this study. The first group is K (only treated with aquadest) and P group (treated by ethanolic neem leaves extrcat at the dosage 14 mg/ kg body weight). The treatment were given orally with a volume of 0.2 mL for 21 days. Feeding and drinking were carried out ad-libitum. At the 22 days, kidney was isolated, weighted and made for histological processed with 5 μm in thickness using paraffin method with Hematoxylin and Eosin staining. The variables observed in this study were kidney weight, water consumption, glomerular diameter, thick of Bowman capsule, diameter of proximal tubule and lumen diameter. Data were analyzed using the t test with a confidence level of 95%. The results of the analysis showed that the treatment has no significant effect (p> 0.05) to kidney weight, water consumption, glomerular diameter, thick of Bowman capsule, diameter of proximal tubules and lumen diameter. The study showed that the use of ethanolic neem leaves extract for 21 days still safe to be use as a traditional medicine.

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Section: Hasil Dan Pembahasanunclassified

Safety Test for Ethanolic Neem Leaf (Azadirachta indica A. Juss.) Extract on Male Mice (Mus musculus L) Renal Structure

Lestari,

Sitasiwi,

Isdadiyanto

2023

Jurnal Sain Veteriner

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“…Exploring natural plant sources has become a significant way in drug discovery. TCM has attracted more and more attention from medical and healthcare workers due to its multi-component, multi-target and multi-channel pharmacological effects (Shi et al, 2022). Especially in the relentless struggle against the COVID-19 epidemic, the important role of TCM has been firmly confirmed.…”

Section: Introductionmentioning

confidence: 99%

Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

Zhou,

Shen,

Hou

2024

Front. Pharmacol.

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Traditional Chinese medicine (TCM) is the practical experience and summary of the Chinese nation for thousands of years. It shows great potential in treating various chronic diseases, complex diseases and major infectious diseases, and has gradually attracted the attention of people all over the world. However, due to the complexity of prescription and action mechanism of TCM, the development of TCM industry is still in a relatively conservative stage. With the rise of artificial intelligence technology in various fields, many scholars began to apply artificial intelligence technology to traditional Chinese medicine industry and made remarkable progress. This paper comprehensively summarizes the important role of artificial intelligence in the development of traditional Chinese medicine industry from various aspects, including new drug discovery, data mining, quality standardization and industry technology of traditional Chinese medicine. The limitations of artificial intelligence in these applications are also emphasized, including the lack of pharmacological research, database quality problems and the challenges brought by human-computer interaction. Nevertheless, the development of artificial intelligence has brought new opportunities and innovations to the modernization of traditional Chinese medicine. Integrating artificial intelligence technology into the comprehensive application of Chinese medicine industry is expected to overcome the major problems faced by traditional Chinese medicine industry and further promote the modernization of the whole traditional Chinese medicine industry.

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“…21,22 Additionally, ongoing studies focusing on the modernization of TCM have revealed an increasing number of TCM compounds that exhibit potential in modulating autophagy. [23][24][25] These compounds present notable advantages compared to traditional chemotherapeutic agents, including platinum-based drugs and anthracyclines, owing to their reduced toxicity, capacity to target multiple sites, and synergistic effects. 26,27 Nevertheless, the widespread presence of indoles and flavonoids in these compounds poses a significant obstacle due to their inadequate water solubility and restricted bioavailability, thereby impeding their potential clinical applicability.…”

Section: Introductionmentioning

confidence: 99%

Exploiting Nanotechnology for Drug Delivery: Advancing the Anti-Cancer Effects of Autophagy-Modulating Compounds in Traditional Chinese Medicine

Liu,

Lu,

Qian

et al. 2024

IJN

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Background: Cancer continues to be a prominent issue in the field of medicine, as demonstrated by recent studies emphasizing the significant role of autophagy in the development of cancer. Traditional Chinese Medicine (TCM) provides a variety of anti-tumor agents capable of regulating autophagy. However, the clinical application of autophagy-modulating compounds derived from TCM is impeded by their restricted water solubility and bioavailability. To overcome this challenge, the utilization of nanotechnology has been suggested as a potential solution. Nonetheless, the current body of literature on nanoparticles delivering TCM-derived autophagymodulating anti-tumor compounds for cancer treatment is limited, lacking comprehensive summaries and detailed descriptions. Methods: Up to November 2023, a comprehensive research study was conducted to gather relevant data using a variety of databases, including PubMed, ScienceDirect, Springer Link, Web of Science, and CNKI. The keywords utilized in this investigation included "autophagy", "nanoparticles", "traditional Chinese medicine" and "anticancer". Results: This review provides a comprehensive analysis of the potential of nanotechnology in overcoming delivery challenges and enhancing the anti-cancer properties of autophagy-modulating compounds in TCM. The evaluation is based on a synthesis of different classes of autophagy-modulating compounds in TCM, their mechanisms of action in cancer treatment, and their potential benefits as reported in various scholarly sources. The findings indicate that nanotechnology shows potential in enhancing the availability of autophagy-modulating agents in TCM, thereby opening up a plethora of potential therapeutic avenues.Conclusion: Nanotechnology has the potential to enhance the anti-tumor efficacy of autophagy-modulating compounds in traditional TCM, through regulation of autophagy.

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Traditional Chinese medicine compounds ameliorating glomerular diseases via autophagy: A mechanism review

Cited by 8 publications

References 134 publications

Safety Test for Ethanolic Neem Leaf (Azadirachta indica A. Juss.) Extract on Male Mice (Mus musculus L) Renal Structure

Safety Test for Ethanolic Neem Leaf (Azadirachta indica A. Juss.) Extract on Male Mice (Mus musculus L) Renal Structure

Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

Exploiting Nanotechnology for Drug Delivery: Advancing the Anti-Cancer Effects of Autophagy-Modulating Compounds in Traditional Chinese Medicine

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