Traditional Chinese medicine attenuates hospitalization and mortality risks in diabetic patients with carcinoma in situ in Taiwan

Tsai, L.-J.; Chung, Chi‐Hsiang; Lin, CJ; Su, Sheng-Chiang; Kuo, Feng-Chih; Liu, Jhih‐Syuan; Chen, Kuan-Chan; Ho, Ling‐Jun; Kuo, Chia‐Chi; Chang, Chun-Yung; Lin, Ming-Hsun; Chu, Nain-Feng; Lee, Chien-Hsing; Hsieh, Chang‐Hsun; Hung, Yi‐Jen; Hsieh, Po‐Shiuan; Lin, Fu-Huang; Lu, Chieh-Hua; Chien, Wu-Chien

doi:10.1016/j.imr.2021.100831

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…[ 21 , 22 ] Previous studies by our team have shown that the adjuvant treatment of combined TCM can effectively reduce the hospitalization and death risks of diabetic patients with carcinoma in situ in Taiwan. [ 12 ] Previous research literature pointed out that TCM treatment of osteoporosis can effectively improve “bone density and improve “pain, joint swelling and other clinical symptoms.” [ 23 ] In addition, according to the statistics of the TNHID, it is also found that patients with osteoporosis can “effectively reduce the probability of fractures” after undergoing TCM treatment. [ 17 ] The efficacy of TCM in treating osteoporosis has a certain empirical basis, while TCM emphasizes the harmony and operation of all viscera when treating osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

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Effects of combined traditional Chinese medicine therapy in patients of lower limbs injuries with osteoporosis: A retrospective paired cohort study

Lu,

Chung,

Lin

et al. 2023

Medicine

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Studies have confirmed that the health hazards of patients with lower limb injuries combined with osteoporosis are more obvious. This study is mainly based on the Taiwan National Health Insurance Database, and through big data analysis, it shows that the combined treatment of traditional Chinese medicine (TCM) is helpful to the health of patients with lower limb injuries combined with osteoporosis. A total of 9989 combined TCM-treated patients and 19,978 2:1 sex-, age-, and index-year-matched controls who did not receive TCM treatment were selected from the Taiwan National Health Insurance Database. Cox proportional hazards analyzes were performed to compare fracture surgery, inpatient, and all-cause mortality during a mean follow-up period of 17 years. A total of 5406/8601/2564 enrolled-subjects (14.11%/25.46%/5.53%) had fracture surgery/inpatient/all-cause mortality, including 1409/2543/552 in the combined TCM group (14.11%/25.46%/5.53%) and 3997/6058/2012 in the control group (20.01%/30.32%/10.07%). Cox proportional hazard regression analysis showed a lower rate of fracture surgery, inpatient and all-cause mortality for subjects in the combined TCM group (adjusted hazard ratios [HR] = 0.723; 95% confidence intervals [CI] = 0.604–0.810, P < .001; adjusted hazard ratios [HR] = 0.803; 95% CI = 0.712–0.950, P = .001; adjusted HR = 0.842; 95% CI = 0.731–0.953, P = .007, respectively). After 10 years of follow-up, the cumulative incidence of fracture surgery in patients combining TCM treatment seems to be half of that without combining TCM treatment those are shown in Kaplan–Meier analysis with statistically significant (log rank, P < .001, P < .001, and P = .010, respectively). This study hopes to provide clinicians with the option of combined TCM treatment for patients of lower limbs injuries combined with osteoporosis, so that such patients will be associate with a lower risk of fracture surgery, inpatient or all-cause mortality.

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Section: Discussionmentioning

confidence: 99%

“…Covariates included Charlson comorbidity index minus osteoporosis, lower limbs injuries, level of care, sex, and age. [ 12 ]…”

Section: Methodsmentioning

confidence: 99%

Effects of combined traditional Chinese medicine therapy in patients of lower limbs injuries with osteoporosis: A retrospective paired cohort study

Lu,

Chung,

Lin

et al. 2023

Medicine

Self Cite

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Study on the Prognosis Effect of Traditional Chinese Medicine Treatment in Patients with Diabetic Neuropathy – A Nationwide, Population-based Study in Taiwan

Chen,

Li,

Huang

et al. 2024

Journal of Medical Sciences

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Background: Diabetic neuropathy (DN) is one of the common chronic complications, leading to limb disability and increased risks of hospitalization and mortality. Traditional Chinese medicine (TCM) has been commonly applied in Taiwan as an adjunctive treatment to ameliorate diabetes-associated chronic complications, including neuropathy. Aim: We aimed to investigate whether the clinical treatment of DN combined with TCM can reduce the associated hospitalization and mortality using the National Health Insurance Research Database (NHIRD) of Taiwan. Methods: We selected 1,152 patients with DN who received TCM treatment as the study cohort group, and 4,940 patients with DN who did not receive TCM treatment from Taiwan NHIRD were further matched 1:1 for sex, age, and index year as the comparison cohort group. Cox proportional hazards analysis was performed to compare hospitalization and mortality during a mean follow-up period of 15 years. Results: A total of 687/225 enrolled patients (29.82%/9.77%) had hospitalization/mortality, including 298/97 in the TCM group (25.87%/8.42%) and 389/128 in the comparison group (33.77%/11.11%). Cox proportional hazard regression analysis showed a lower rate of hospitalization and mortality for patients in the TCM group (adjusted hazard ratio [HR] of 0.434, 95 confidence interval [CI] =0.172–0.798, P < 0.001; adjusted HR of 0.689, 95 CI = 0.372–0.981, P = 0.039). The Kaplan–Meier analysis showed that the cumulative risk of hospitalization and mortality in the study and comparison cohort groups was significantly different (log-rank P < 0.001 and P = 0.007, respectively). Conclusion: Our results suggest that the application of TCM might be beneficial for patients with DN to lower the risks of hospitalization and mortality; however, further prospective cohort studies are still required to confirm our observations.

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Traditional Chinese medicine attenuates hospitalization and mortality risks in diabetic patients with carcinoma in situ in Taiwan

Cited by 2 publications

References 33 publications

Effects of combined traditional Chinese medicine therapy in patients of lower limbs injuries with osteoporosis: A retrospective paired cohort study

Effects of combined traditional Chinese medicine therapy in patients of lower limbs injuries with osteoporosis: A retrospective paired cohort study

Study on the Prognosis Effect of Traditional Chinese Medicine Treatment in Patients with Diabetic Neuropathy – A Nationwide, Population-based Study in Taiwan

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