Traditional Chinese Medicine as Potential Therapy for COVID-19

Li, Shuang; Liu, Chang; Guo, Fengjin; Taleb, Sarah J; Tong, Man‐Li; Shang, Dong

doi:10.1142/s0192415x20500627

Cited by 18 publications

(15 citation statements)

References 84 publications

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“…Although a great quantity of review articles have been published on the topic of TCM in COVID-19 13 , 14 , 19 , 23 , 25 , 35 , 71 , 87 , 168 , 171 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , our work offers something unique. 1) To our knowledge, this is the first review of TCM on COVID-19 that integrates evidence-based scientific findings from bedside to bench with the most comprehensive and updated literatures.…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese medicine in COVID-19

Lyu

Fan

Xiao

et al. 2021

Acta Pharmaceutica Sinica B

149

118

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COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across the globe, posing an enormous threat to public health and safety. Traditional Chinese medicine (TCM), in combination with Western medicine (WM), has made important and lasting contributions in the battle against COVID-19. In this review, updated clinical effects and potential mechanisms of TCM, presented in newly recognized three distinct phases of the disease, are summarized and discussed. By integrating the available clinical and preclinical evidence, the efficacies and underlying mechanisms of TCM on COVID-19, including the highly recommended three Chinese patent medicines and three Chinese medicine formulas, are described in a panorama. We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19, but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM.

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Section: Discussionmentioning

confidence: 99%

Traditional Chinese medicine in COVID-19

Lyu

Fan

Xiao

et al. 2021

Acta Pharmaceutica Sinica B

149

118

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“…There is an increasing need for the development of diverse prophylactic and therapeutic options against COVID-19. The majority of patients with COVID-19 have been treated with traditional herbal medicine in combination with standard pharmacotherapy in China since the outbreak (1)(2)(3)(4). Several newly developed herbal formulas were encouraged for the management of COVID-19 in the latest version of the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7) released by the National Health Commission of China (5).…”

Section: Introductionmentioning

confidence: 99%

Qingfei Paidu decoction, a Chinese herbal medicine against COVID‑19, elevates the blood levels of pro‑inflammatory cytokines: An open‑label, single‑arm pilot study

Kageyama¹,

Aida²,

Kawauchi³

et al. 2021

World Acad Sci J

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Qingfei Paidu decoction (QFPD) is a Chinese herbal medicine newly formulated for the treatment of COVID-19. QFPD significantly enhances the therapeutic effects of standard pharmacotherapy in mild to critically ill patients with COVID-19. However, limited information is available on the immunological mechanisms underlying the efficacy of QFPD. In addition, the feasibility of the prophylactic administration of QFPD to uninfected individuals remains unconfirmed. To obtain insight into these issues, an open-label, single-arm pilot study was conducted using 19 healthy uninfected individuals as subjects, and the effects of QFPD ingestion at a dose lower than that recommended for therapeutic use on hematological and immunological parameters were examined. QFPD was prepared according to the Chinese official clinical guideline, except that the dose of each herb was reduced to 1/30 and administered orally to the participants twice daily for 3 days. Low-dose QFPD ingestion significantly increased the plasma levels of pro-inflammatory cytokines, tumor necrosis factor (TNF)-α (P= 0.000107), interleukin (IL)-1β (P=0.000982), IL-18 (P=0.00105), IL-2 (P=0.0483) and IL-8 (P=0.000191), key mediators of a broad spectrum of antiviral immunity. No apparent adverse effects were observed during the trial. These findings suggest that the clinical efficacy of QFPD against COVID-19 is, at least in part, associated with its immunological activity to mimic the blood cytokine environment produced by early antiviral immune responses, which are shown to be profoundly suppressed during the early stages of COVID-19. The daily ingestion of low-dose QFPD may thus be a possible option for the prevention of COVID-19 during the epidemic. The present study was prospectively registered at the University Hospital Medical Information Network-Clinical Trials Registry (UMIN-CTR) under the trial no. UMIN000040341 on May 9, 2020.

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“…“Safe” of TCMs is not the same as “natural”. Some TCMs have endogenous toxicity to organs such as liver and kidney, and also exogenous toxicity in the process of cultivation, processing, storage and distribution ( Li et al, 2020c ). Therefore, the further development of TCMs in the world must determine its side effects.…”

Section: Development Prospects Of Antiviral Tcmsmentioning

confidence: 99%

Progress in Traditional Chinese Medicine Against Respiratory Viruses: A Review

Liu

et al. 2021

Front. Pharmacol.

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Respiratory viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV)-1, SARS-CoV-2, influenza A viruses, and respiratory syncytial virus, pose a serious threat to society. Based on the guiding principles of “holism” and “syndrome differentiation and treatment”, traditional Chinese medicine (TCM) has unique advantages in the treatment of respiratory virus diseases owing to the synergistic effect of multiple components and targets, which prevents drug resistance from arising. According to TCM theory, there are two main strategies in antiviral treatments, namely “dispelling evil” and “fu zheng”. Dispelling evil corresponds to the direct inhibition of virus growth and fu zheng corresponds to immune regulation, inflammation control, and tissue protection in the host. In this review, current progress in using TCMs against respiratory viruses is summarized according to modern biological theories. The prospects for developing TCMs against respiratory viruses is discussed to provide a reference for the research and development of innovative TCMs with multiple components, multiple targets, and low toxicity.

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Traditional Chinese Medicine as Potential Therapy for COVID-19

Cited by 18 publications

References 84 publications

Traditional Chinese medicine in COVID-19

Traditional Chinese medicine in COVID-19

Qingfei Paidu decoction, a Chinese herbal medicine against COVID‑19, elevates the blood levels of pro‑inflammatory cytokines: An open‑label, single‑arm pilot study

Progress in Traditional Chinese Medicine Against Respiratory Viruses: A Review

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