Traditional Chinese herbal medicine in treating amenorrhea caused by antipsychotic drugs: Meta-analysis and systematic review

Liu, Liangshuai; Li, Heping; Tan, Guangming; Ma, Zhen

doi:10.1016/j.jep.2022.115044

Cited by 9 publications

(5 citation statements)

References 40 publications

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“…The endoplasmic reticulum stress pathway is a recently discovered apoptosis signaling pathway which is involved in a variety of pathological and physiological events in vivo, and it is linked to the pathogenesis of cardiovascular diseases. Endoplasmic reticulum stress (ERS) induces upregulations of GRP78 and GRP94 in vascular and arterial smooth muscle cells at the initial stage, and promotes degradation of unfolded or misfolded proteins, thereby relieving endoplasmic reticulum pressure; maintains cellular homeostasis, and protect the cells [13]. However, excessive or prolonged ERS may activate the expressions of pro-apoptotic factors such as caspase-12 and CHOP, thereby causing cell metabolic disorders.…”

Section: Discussionmentioning

confidence: 99%

Effect of enalapril maleate-folic acid tablets on inflammatory response and myocardial endoplasmic reticulum stress-related factors in hypertensive rats

Zu¹,

Zhang²,

Feng³

2022

Trop. J. Pharm Res

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Purpose: To determine the effect of enalapril maleate folate on inflammatory reaction and myocardial endoplasmic reticulum stress-related factors in hypertensive rats.Methods: Eighty (80) hypertensive rats with SBP > 140 mmHg were equally assigned to control and study groups. Rats in control group were given normal saline by gavage, while the observation group was given enalapril maleate powder (10 mg/kg/day). After 4 weeks of treatment, 2 mL of inferior vena cava blood was collected from each of the two rat groups. The level of homocysteine (Hcy) was determined with Hcy assay kit, while C-reactive protein (CRP) levels in patients were determined by latex immunoturbidimetry. Serum FBG was assessed using automatic biochemical analyzer. The expression levels of GRP78, CRP94, chop and caspase-12 in aortic smooth muscle cells were assayed immunohistochemically.Results: Central arterial pressure (MAP), aortic media thickness, lvwi, HWI FBG and CRP were significantly higher in the study rats, while Hcy level was lower, than in controls (p < 0.05). There were significantly lower levels of glucose regulatory protein 78 (GRP78), CRP94, CHOP and caspase-12 in study rats than in control rats (p < 0.05).Conclusion: Enalapril maleate-folate slows down inflammatory reaction by reducing the levels of Hcy, CRP and FBG. It inhibits the expressions of GRP78, CRP94, CHOP and caspase-12 in myocardium, reduces damage to myocardial cells, and alleviates or reverses left ventricular hypertrophy in rats with high blood pressure. This provides new insight into the research and development of other drugs.

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Section: Discussionmentioning

confidence: 99%

Effect of enalapril maleate-folic acid tablets on inflammatory response and myocardial endoplasmic reticulum stress-related factors in hypertensive rats

Zu¹,

Zhang²,

Feng³

2022

Trop. J. Pharm Res

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“…Nonlaying hens were considered to be associated with a reduction in serum LH and LYF and SYF numbers, which was reversed after GnRH injection ( Hanafy and Elnesr, 2021 ). In addition, Angelica sinensis, Bupleurum chinense, Leonurus japonicus , and Paeonia lactiflora have traditionally been used to replenish, invigorate blood circulation and treat menstrual disorder ( Liu et al, 2022 ). Consistently, Angelica sinensis and Paeonia lactiflora have been used in clinical to treat polycystic ovary syndrome ( Zeng et al, 2022 ; Gao et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary Chinese herbal mixture supplementation improves production performance by regulating reproductive hormones, antioxidant capacity, immunity, and intestinal health of broiler breeders

Liu,

Chen,

Wang

et al. 2024

Poultry Science

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“…TCM usually contains various chemical compositions; thus, data on their treatment effects, mechanisms of action, and toxicology characteristics are frequently limited [ 14 ]. Therefore, it becomes the focus of the research concerning the identification of chemical compositions of such medicines, evaluation of biological, and standardization of safety quality [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanism and Pharmacodynamic Substance Basis of Raw and Wine-Processed Evodia rutaecarpa on Smooth Muscle Cells of Dysmenorrhea Mice

Liu

Hong

Chen

et al. 2023

Pain Research and Management

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Objectives. Evodia rutaecarpa (ER) is a well-known herbal Chinese medicine traditionally used for analgesia in dysmenorrhea, headaches, abdominal pain, etc. Notably, the analgesic effect of wine-processed Evodia rutaecarpa (PER) was more potent than that of raw ER. This research aimed to investigate the mechanism and pharmacodynamic substance basis of raw ER and PER on smooth muscle cells of dysmenorrhea mice. Methods. Metabolomics methods based on UPLC-Q-TOF-MS were utilized to analyse the differential components of ER before and after wine processing. Afterwards, the uterine smooth muscle cells were isolated from the uterine tissue of dysmenorrhea and normal mice. The isolated dysmenorrhea uterine smooth muscle cells were randomly divided into four groups: model group, 7-hydroxycoumarin group (1 mmol/L), chlorogenic acid (1 mmol/L), and limonin (50 μmol/L). The normal group consisted of the isolated normal mouse uterine smooth muscle cells, which were repeated 3 times in each group. The cell contraction and the expression of P2X3 and Ca2+ in vitro were determined using immunofluorescence staining and laser confocal; ELISA was used for detection of PGE2, ET-1, and NO content after 7-hydroxycoumarin, chlorogenic acid, and limonin administered for 24 h. Results. The metabolomics results suggested that seven differential compounds were identified in the extracts of raw ER and PER, including chlorogenic acid, 7-hydroxycoumarin, hydroxy evodiamine, laudanosine, evollionines A, limonin, and 1-methyl-2-[(z)-4-nonenyl]-4 (1H)-quinolone. The in vitro results showed that 7-hydroxycoumarin, chlorogenic acid, and limonin were able to inhibit cell contraction and PGE2, ET-1, P2X3, and Ca2+ in dysmenorrhea mouse uterine smooth muscle cells and increase the content of NO. Conclusion. Our finding suggested that the compounds of the PER were different from those of the raw ER, and 7-hydroxycoumarin, chlorogenic acid, and limonin could improve dysmenorrhea in mice whose uterine smooth muscle cell contraction was closed with endocrine factors and P2X3-Ca2+ pathway.

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Traditional Chinese herbal medicine in treating amenorrhea caused by antipsychotic drugs: Meta-analysis and systematic review

Cited by 9 publications

References 40 publications

Effect of enalapril maleate-folic acid tablets on inflammatory response and myocardial endoplasmic reticulum stress-related factors in hypertensive rats

Effect of enalapril maleate-folic acid tablets on inflammatory response and myocardial endoplasmic reticulum stress-related factors in hypertensive rats

Dietary Chinese herbal mixture supplementation improves production performance by regulating reproductive hormones, antioxidant capacity, immunity, and intestinal health of broiler breeders

Mechanism and Pharmacodynamic Substance Basis of Raw and Wine-Processed Evodia rutaecarpa on Smooth Muscle Cells of Dysmenorrhea Mice

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