Traditional Applications of Tannin Rich Extracts Supported by Scientific Data: Chemical Composition, Bioavailability and Bioaccessibility

Fraga-Corral, María; Otero, Paz; Cassani, Lucía; Echave, Javier; García-Oliveira, Paula; Carpena, María; Chamorro, Franklin; Lourenço-Lopes, Catarina; Prieto, Miguel A.; Simal-Gándara, Jesús

doi:10.3390/foods10020251

Cited by 60 publications

(41 citation statements)

References 177 publications

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“…Phlorotannins are common tannins that can be found in a variety of brown macroalgae species of Sargassum , Ecklonia , and Fucus ( Saragassum fusiforme, Sargasum muticuma, Fucus vesiculosus, Eclonia maxima , etc.) [ 163 , 164 , 165 , 166 , 167 , 168 ], and, like fucoidans, they are not present in terrestrial plants [ 169 ]. Phlorotannins are constituted of molecules of phloroglucinol that polymerize with ease between C1 and C3.…”

Section: Isolation Of High-value Molecules With Neuroprotective Effects Against Alzheimer’s Diseasementioning

confidence: 99%

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

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Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds.

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Section: Isolation Of High-value Molecules With Neuroprotective Effects Against Alzheimer’s Diseasementioning

confidence: 99%

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

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“…The position of the dimer is also confirmed from the carbon chemical shift value that it is downfield shifted than the value of C-6'' (δC 144.8) for 2''',4''',6'''-benzentriol-(7''-hydroxylphenyl)-2'',3''-dihydroxylpropyl monomer. It is worth to mention that biflavonoids including those with C-O-C linkage are common to the genus [15][16][17][18]. OMe) identified as 2',4',4'',2'''-tetrahydroxy-4'''-methoxy-4-O-5'''-bichalcone [19].…”

Section: Resultsmentioning

confidence: 99%

Biflavonoids from the roots of Rhus ruspolii and evaluations of their antioxidant activities

Deresa¹,

Abdissa²,

Gurmessa³

et al. 2022

Bull. Chem. Soc. Eth.

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ABSTRACT. Biflavonoids are C-C or C-O-C linked flavonoid dimers with highly restricted presence in plant species. They are extensively reported to possess interesting pharmacological properties. The chromatographic fractionation and purification of CH2Cl2/MeOH (1:1) extract of the root of Rhus ruspolli led to the isolation of a new biflavonoid (1) along with four other known biflavonoids (2-5). The structure of the compounds were identified based on the analysis of NMR spectroscopic and mass spectrometric data and also in comparison with reported literature data. Compounds 2-5 were assayed for their antioxidant activity using DPPH and displayed potent in vitro antioxidant activities. The percentage radical scavenging activities were 78.32, 68.90, 93.22 and 92.00 for compounds 2-5, respectively. The highest activity was observed for compound 4 and 5 with IC50 values of 7.90 and 8.40, respectively, which are even greater than that of ascorbic acid (IC50 9.90). The high antioxidant activity of the compounds could be due to the presence of free hydroxyl groups in the flavonoids. The antioxidant activities of these compounds support the traditional uses of the plant in treatment of wound, ectoparasite and as antibacteria and indicates the potential use of these compounds as drug lead candidates. KEY WORDS: Rhus ruspolii, Roots, Biflavonoids, Chalcones, Antioxidant activity Bull. Chem. Soc. Ethiop. 2022, 36(3), 667-674. DOI: https://dx.doi.org/10.4314/bcse.v36i3.15

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“…Clinically, tannins have been used against inflammation and injuries (Pizzi, 2021). Herbs containing tannins as a major constituent have been suggested to treat intestinal disorders like diarrhea and dysentery (Fraga et el., 2021).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and antibacterial analyses of Onychium japonicum (Thunb.) Kunze

Shah

Hassan

Alsanie

et al. 2022

Preprint

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In clinical practice bacterial resistance against antibiotics has become a serious health problem, thus using alternative approaches such as natural products as the supplementary drug could solve it. Therefore, the current study was conducted to thoroughly investigate the enrichment of phytochemicals and antibacterial potential of O. japonicum. The fronds samples of O. japonicum prepared in different solvents were used against MDR bacterial strains and phytochemical analyses. The analyses of data revealed that O. japonicum was enriched with flavonoids, alkaloids, saponins, tannins, glycosides, carotenoids, terpenoids, phlobatanins, phenols, and coumarins while quantitatively this plant has a significantly higher content of phenols(1100.91µM/g) followed by sugar contents (748.67µM/ml), ascorbic acid (426.12mM/g), flavonoids (160.65mg/g), anthocyanin (101.06µM/g) and proline (80.58µM/g). On the other hand, the organic extracts of O. japonicum were highly active against all bacterial strains while hydric extract was inactive against selected bacteria. Specifically, O. japonicum was highly active against S. aureus in all organic extracts (chloroform=16.66±0.33, ethyl acetate=15±0.57, methyl alcohol= 14±0.57, N-hexane=20.33±0.33) followed by K. pneumonia (chloroform=14.33±0.33, ethyl acetate=4.33±4.33, methyl alcohol=3.66±3.66, N-hexane=16.66±0.33) and P. aeruginosa (chloroform= 8.33±4.17, ethyl acetate=8.33±4.17, methyl alcohol=6±3.00, N-hexane=9.33±4.66), while E. coli (chloroform=0±0.00, ethyl acetate=7±3.51, methyl alcohol=3.33±3.33, N-hexane=4±4.00). Based on current findings it is concluded that O. japonicum is enriched in many useful phytochemicals that could be use as a supplement with other traditionally used antibiotics.

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Traditional Applications of Tannin Rich Extracts Supported by Scientific Data: Chemical Composition, Bioavailability and Bioaccessibility

Cited by 60 publications

References 177 publications

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Biflavonoids from the roots of Rhus ruspolii and evaluations of their antioxidant activities

Phytochemical and antibacterial analyses of Onychium japonicum (Thunb.) Kunze

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