Traditional and Novel Methods for Cocrystal Formation: A Mini Review

The inherent contradiction between the energy density and safety of energetic materials (EMs) is very challenging. To solve this problem, cocrystallization technology has been usually used in the field of EMs to better balance the energy and safety. The preparation techniques of energetic cocrystals mainly include solvent evaporation, solvent/nonsolvent, and grinding methods. The cocrystals prepared by these methods have structures completely different from the starting crystals. The comprehensive performance of energetic cocrystals (ECCs), such as density, solubility, sensitivity, and thermal stability, is significantly improved. This review summaries the preparation methods of ECCs and their fundamental formation mechanisms, where the HMX-based and CL-20-based ECCs are selected as typical examples. Their structures, sensitivity, thermodynamic characteristics, and detonation parameters are summarized and compared in detail. Finally, future research directions and challenges of ECCs are proposed based on this literature survey.

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Section: Cocrystallization Of Energetic Compoundsmentioning

confidence: 99%

Nitramine-Based Energetic Cocrystals with Improved Stability and Controlled Reactivity

Xue

Huang

et al. 2020

Crystal Growth & Design

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“…Ant Colony Optimization algorithm (ACO) was introduced by Dorigo M. [3] in 1991. The foraging behavior of an ant colony [4], [5], [6] is the main motivation behind the algorithm. Problems such as job scheduling [7] problem(JSP), traveling salesman problem (TSP), network routing(NR) and vehicle routing problem(VRP) and many more where ASO has been used popularly.…”

Section: Related Workmentioning

confidence: 99%

Analysis of Nature Inspired Algorithms

2020

jcr

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Nature Inspired Optimization algorithms has grabbed a significant notice for their methodologies in problem solving. Some of the popular nature inspired algorithms which were used for optimization are Genetic Algorithms (GS), Particle Swam Optimization (PSO), Fuzzy Systems (FS), Artificial Neural Network (ANN), Cuckoo Search (CS). Several real world problems are achieved using nature inspired algorithms and also optimization with these algorithms place a crucial role in solving the problems. In our project we were implementing various nature inspired algorithms and compare among them in terms of performance, speed, and their ability to reach best solution.

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“…Slow evaporation (Barikah, 2018) was used to grow single crystals, using about 15 mg of metronidazole benzoate, the corresponding amount of the selected coformer and 2 ml of ethanol as solvent. The API-coformer stoichiometric ratio used was based on the number of OH groups present in each coformer.…”

Section: Solution Growth Of Single Crystalsmentioning

confidence: 99%

“…Several methods can be used in order to obtain new solid forms (Delori et al, 2012;Do & Friscic, 2017;Douroumis et al, 2017;Hasa & Jones, 2017;James et al, 2012). In this study, the rational design provided by crystal engineering was aligned to the traditional solventevaporation methodology (Barikah, 2018), which has been applied successfully with a large number of APIs (Diniz et al, 2018;Sarkar & Rohani, 2015;. Following this strategy, thirteen new solid forms (two salts and eleven cocrystals) were obtained successfully employing crystal engineering principles by selecting suitable coformers (Fig.…”

Section: Introductionmentioning

confidence: 99%