Traditional and Alternative Treatments for Depression: Implications for Migraine Management

Abstract

Clinical implications and treatment strategies for migraine patients with comorbid depression are discussed. The literature reviewed here draws together clinical practice options for clinicians.

Migraine and its psychiatric comorbidities

“…Third, the treatment of migraine and the psychiatric comorbidities should be carried out in a sequential stepwise manner with close monitoring of potential side effects and treatment interactions 11. Attempts should be made to avoid migraine preventives that can potentially worsen patients’ psychiatric comorbidities.…”

Migraine and depression: efficacy and safety of antidepressant therapy

“…[14], включившей несколько тысяч наблюдений, было показано, что де-прессия предшествует хронификации мигрени. Соглас-но одной из теорий [18] развитие депрессии сопровож-дается снижением уровня моноаминов (серотонин, но-радреналин) в нейронах головного мозга. Происходит снижение функции серотонинергических нейронов околоводопроводного серого вещества, что является ос-новным патофизиологическим механизмом трансфор-мации эпизодической мигрени в хроническую (цен-тральная сенситизация) [19].…”

Associations Between Migraine and the Most Common Psychiatric Co‐Morbidities

“…The relationship between migraine and depression may also influence the choice of treatment for either or both conditions. Peck et al reviewed various treatment modalities for depression and the implications for comorbid migraine. The authors discussed cognitive behavioral therapy (CBT) and how its specific components, behavioral activation and cognitive restructuring, are designed to increase constructive activities and challenge maladaptive thoughts and behaviors.…”