Tradeoff between risks through ingestion of nanoparticle contaminated water or fish: Human health perspective

Parsai, Tanushree; Kumar, Arun

doi:10.1016/j.scitotenv.2020.140140

Cited by 22 publications

(10 citation statements)

References 59 publications

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“…Amongst the NPs studied, high risk values were observed for ZnO NPs compared to others. Similar to the other cases, here also, absorption of ZnO NPs in the human digestive system was found to be the highest Parsai and Kumar (2020). found high HQ values for ZnO NPs thorough fish consumption exposure.…”

supporting

confidence: 87%

“…Larger the size of nanoparticles higher is the accumulation potential in the human digestive system (Bergin and Witzmann, 2013). The observed sequence of nanoparticles in the human digestive system is similar to those observed by Parsai and Kumar (2020).…”

Section: Estimation Of Nanoparticles and Antibiotics Loading In The Digestive Mediasupporting

confidence: 72%

“…If we compare the Cmax values of metal ions with that of nanoparticles, it can be seen that the Zn 2+ ions (0.658 mg/L) showed comparatively high Cmax values than ZnO NPs (6.27 mg/L). Previous studies also reported high Cmax values for ZnO NPs in water bodies for the inadvertent ingestion of NPs through fish consumption exposure (Parsai and Kumar, 2020). Similar Cmax values for Ti 2+ ions and TiO2 NPs, and Fe 3+…”

Section: Maximum Allowable Concentration Of Metal Ions Nanoparticles and Antibiotics In Watersupporting

confidence: 55%

“…Looking into the potential adverse effects of these contaminants on human health, risk assessment studies have been conducted for some classes, for example, nanoparticles (Parsai and Kumar, 2020), pharmaceutical drugs (antibiotics) (Kumari and Kumar, 2020) etc., (Supplementary Table S1) but none of the reported studies (as per authors best knowledge) have tried to capture the interaction aspect linked with nanoparticles and antibiotics in natural water systems. Lack of available guidelines and regulations adds to the ongoing problem and makes it even more difficult, if not properly taken care of.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, in this case, the provisional RfD (p-RfD) values for iron, derived using the lowest-observed-adverse-effect level (LOAEL) and uncertainty factor (UF) was considered (U.S. EPA, 2006b). RfD values of other nanoparticles i.e., ZnO NPs and CuONPs is taken from recently published work(Parsai and Kumar, 2020). ADI values of individual antibiotics used to estimate the PNEC values is taken from published literature.…”

mentioning

confidence: 99%

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Estimating combined health risks of nanomaterials and antibiotics from natural water: a proposed framework

Kumari

Kumar

2021

Environ Sci Pollut Res

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Nanoparticles are the major class of emerging contaminant detected at relatively high concentrations in aquatic environment. They are likely to co-exist with other chemical pollutants such as antibiotics in natural water systems. There are chances that if they are taken up orally, might pose adverse effects to human health. To address this issue, a risk framework is developed to study the combined exposure of nanoparticles and antibiotics in natural waters for the first time. The framework was applied to a hypothetical exposure of nanoparticles (CuO, ZnO, Fe3O4 and TiO2) and antibiotics (ciprofloxacin, CIP; ofloxacin, OFX; norfloxacin, NOR; levofloxacin, LEVO) to estimate human risks in a six-step approach for two different exposure scenarios i.e. availability adsorption isotherm data and vice versa.Risk was also estimated for the released fragments of antibiotics, nanoparticles and metal ions in the human digestive system. Mixture toxicity risk assessment was conducted for pairs (i) antibiotics and metal ions, (ii) antibiotics and nanoparticles, and (iii) nanoparticles and metals ions. Though the estimated risk values were observed to be less than 1 (both hazard quotients and hazard interactions less than 1) for all the conditions and assumptions made but it requires through monitoring of the studied contaminants in water to protect humans from their adverse effects, if any. Maximum allowable concentrations at which no risk occurs to humans was found to be (maximum values): antibiotics (233.8 µg/L, NOR); metal ions (1.02 × 10 9 mg/L, Ti 2+ ions), and nanoparticles (6.68 × 10 5 mg/L, TiO2), respectively.

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supporting

confidence: 87%

Section: Estimation Of Nanoparticles and Antibiotics Loading In The Digestive Mediasupporting

confidence: 72%

Section: Maximum Allowable Concentration Of Metal Ions Nanoparticles and Antibiotics In Watersupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Estimating combined health risks of nanomaterials and antibiotics from natural water: a proposed framework

Kumari

Kumar

2021

Environ Sci Pollut Res

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Meta‐analysis of Bioaccumulation Data for Nondissolvable Engineered Nanomaterials in Freshwater Aquatic Organisms

Zheng

Nowack

2022

Enviro Toxic and Chemistry

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Understanding the bioaccumulation of engineered nanomaterials (ENMs) is essential for making regulatory decisions on potential environmental risks. Research in the field of ENM bioaccumulation has increased in recent years, but the compilation and statistical analysis of the available experimental data have not been updated. We therefore performed a meta-analysis of the existing literature on the bioaccumulation of eight types of nondissolvable ENMs (titanium dioxide [TiO 2 ], aluminum oxide [Al 2 O 3 ], gold [Au], fullerene [C 60 ], carbon nanotubes, iron oxide [FeO x ], graphene, and polystyrene) in nonmammalian freshwater aquatic organisms across three trophic levels including phytoplankton, zooplankton, and fish. Three typical endpoints were used to assess the bioaccumulation potential: the bioconcentration factor (BCF), the bioaccumulation factor (BAF), and the biomagnification factor (BMF). Our results suggest that zooplankton has greater mean logarithmic BCF and BAF values than phytoplankton (3.31 vs. 1.42) and fish (2.04). The ENMs are biomagnified in zooplankton, with a mean BMF of 17.4, whereas trophic transfer from primary consumers (zooplankton) to secondary consumers (fish) was not observed (mean BMF of 0.13). No clear dependency was identified between the physicochemical characteristics of ENMs (e.g., primary particle size, zeta potential, or shape) and bioaccumulation, except for coated versus uncoated particles accumulated in phytoplankton. Carbonaceous ENMs were found to be more bioaccumulated than the other ENMs we considered, except for TiO 2 . A meta-analysis of bioaccumulation data can (1) deepen the understanding of bioconcentration, bioaccumulation, and biomagnification of ENMs, (2) be used to support grouping strategies as a basis for a safer-by-design approach for ENMs, (3) be integrated into comprehensive hazard and risk assessments, (4) promote the standardization of testing guidelines, and (5) enhance future kinetic bioaccumulation modeling.

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Plant Biostimulation with Nanomaterials: A Physiological and Molecular Standpoint

González-Morales,

Cárdenas-Atayde,

Garza-Alonso

et al. 2022

Inorganic Nanopesticides and Nanofertilizers

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Tradeoff between risks through ingestion of nanoparticle contaminated water or fish: Human health perspective

Cited by 22 publications

References 59 publications

Estimating combined health risks of nanomaterials and antibiotics from natural water: a proposed framework

Estimating combined health risks of nanomaterials and antibiotics from natural water: a proposed framework

Meta‐analysis of Bioaccumulation Data for Nondissolvable Engineered Nanomaterials in Freshwater Aquatic Organisms

Plant Biostimulation with Nanomaterials: A Physiological and Molecular Standpoint

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