Trade-off between age of first reproduction and survival in a female primate

Blomquist, Gregory E.

doi:10.1098/rsbl.2009.0009

Cited by 79 publications

(59 citation statements)

References 31 publications

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“…The following empirical observations would seem consistent with this claim: (1) perinatal and childhood adversity plays an etiological role in the programming of late-life disease, resulting in increased morbidity and reduced longevity [2,12]; (2) increased fertility coincides with reduced longevity in birds and mammals [13], as well as in primates [14], although this association has not gone unchallenged in the human case [15][16][17]. From an evolutionary life-history perspective, organisms facing risks that could reduce their chances of surviving to reproductive age should, if possible, accelerate their development and thereby increase their prospects of passing on genes to future generations before becoming unable to do so due to an early death [7,18].…”

Section: Introductionsupporting

confidence: 64%

Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

Shalev

Belsky

2016

Medical Hypotheses

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a b s t r a c tTwo seemingly independent bodies of research suggest a two-hit model of accelerated aging, one highlighting early-life stress and the other reproduction. The first, informed by developmental models of earlylife stress, highlights reduced longevity effects of early adversity on telomere erosion, whereas the second, informed by evolutionary theories of aging, highlights such effects with regard to reproductive cost (in females). The fact that both early-life adversity and reproductive effort are associated with shorter telomeres and increased oxidative stress raises the prospect, consistent with life-history theory, that these two theoretical frameworks currently informing much research are tapping into the same evolutionarydevelopmental process of increased senescence and reduced longevity. Here we propose a mechanistic view of a two-hit model of accelerated aging in human females through (a) early-life adversity and (b) early reproduction, via a process of telomere erosion, while highlighting mediating biological embedding mechanisms that might link these two developmental aging processes.

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Section: Introductionsupporting

confidence: 64%

Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

Shalev

Belsky

2016

Medical Hypotheses

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“…Previous work on this population observed a positive genetic correlation between AFR and longevity, suggesting that genes for early reproduction are also associated with reduced lifespan [61]. Similarly, a study of Rhesus macaques (Macaca mulatta) found a positive genetic correlation between AFR and survival to various stages of adulthood [62]. While AFR and ELF are different traits, these results do suggest that to some extent the trade-off between reproduction at early ages and survival in later life may have a genetic basis, though we do not suggest that our results here provide evidence for such a trade-off at the genetic level.…”

Section: Discussionmentioning

confidence: 94%

Early-life reproduction is associated with increased mortality risk but enhanced lifetime fitness in pre-industrial humans

2015

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The physiology of reproductive senescence in women is well understood, but the drivers of variation in senescence rates are less so. Evolutionary theory predicts that early-life investment in reproduction should be favoured by selection at the cost of reduced survival and faster reproductive senescence. We tested this hypothesis using data collected from preindustrial Finnish church records. Reproductive success increased up to age 25 and was relatively stable until a decline from age 41. Women with higher early-life fecundity (ELF; producing more children before age 25) subsequently had higher mortality risk, but high ELF was not associated with accelerated senescence in annual breeding success. However, women with higher ELF experienced faster senescence in offspring survival. Despite these apparent costs, ELF was under positive selection: individuals with higher ELF had higher lifetime reproductive success. These results are consistent with previous observations in both humans and wild vertebrates that more births and earlier onset of reproduction are associated with reduced survival, and with evolutionary theory predicting trade-offs between early reproduction and later-life survival. The results are particularly significant given recent increases in maternal ages in many societies and the potential consequences for offspring health and fitness.

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“…Postponing or elimination of reproduction extends the lifespan of the animals [34]. Some studies have reported a positive correlation between maternal age at reproduction and female longevity [35,[38][39][40]. In C. elegans, laser ablation of germ cells in the gonad significantly extends lifespan [41].…”

Section: A Trade-off Between Reproduction and Lifespan?mentioning

confidence: 99%

“…There has been a popular theory which proposes that reproduction relocates the limited resources for cell survival and shortens lifespan of the animals [34][35][36][37]. From an evolutionary point of view, investment in reproduction, a new conception may risk one's own survival, future reproductive opportunities, and/or current offspring survival.…”

Section: A Trade-off Between Reproduction and Lifespan?mentioning

confidence: 99%

Mechanisms of reproductive aging in the females

Deng

2012

Sci. China Life Sci.

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Aging is a developmental process occurring in all living organisms after reaching a critical developmental stage, characterized by progressive loss of functions until death. Different cells/tissues age differently depending on epigenetics and cell-cell interactions. While males maintain fertility for the most part of their life females only maintain reproductive ability for a short time compared with their lifespan. The interesting question is why and how the females lose fertility so quickly. There have been many hypotheses proposed from different perspectives and recent research has revealed unusual interactions between germ cells and somatic cells which may determine the lifespan of reproduction in the females. This review briefly discusses recent progress in reproductive aging in the well studied model, C. elegans, and focuses on the molecular mechanisms which may be conserved across all animals including humans. aging, females, oocytes, lifespan, growth factors, mTOR Citation:Deng M Q. Mechanisms of reproductive aging in the females. Sci China Life Sci, 2012, 55: 653 -658,

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Trade-off between age of first reproduction and survival in a female primate

Cited by 79 publications

References 31 publications

Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

Early-life reproduction is associated with increased mortality risk but enhanced lifetime fitness in pre-industrial humans

Mechanisms of reproductive aging in the females

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