Traction Retinal Detachment

A comparative study of epiretinal membranes associated with Eales' disease: a clinicopathologic evaluation

“…They include retinal pigment epithelium (RPE) and retinal glial cells in proliferative vitreoretinopathy (PVR), vascular endothelium, fibroblasts, and macrophages in retinal vasoproliferative disorders such as diabetic retinopathy and vascular occlusions and blood cellular components in inflammatory disorders. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Aetiopathogenesis of Eales' disease is not well understood because of lack of appropriate specimen for microbiology and histopathology studies. The availability of tissue specimen in active stages of the disease is quite unlikely because it is a disease of young healthy persons and involves the retinal periphery in its early stages.…”

Change in Vitreous Collagen after Penetrating Injury

“…Fibro blasts may cause traction of collagen fibers in altered vitreous. It has also been sug gested that the increase of intracellular actin within fibroblasts or fibroblast-like cells play a role in traction retinal detachment after penetrating injury or combined with massive periretinal proliferation [21,22].…”

Investigations on Contractile Properties of Retinal Pigment Epithelial Cells

“…In animal models of PVR, as well as in naturally occur ring PVR in humans, myofibroblast-like cells have been observed in the membranes [4][5][6]. Cells cultured from intravitreal membranes re moved at surgery have been shown to contain microfilaments [7,8], and it has been suggest ed that membrane contraction in PVR is a cell mediated event [9].…”