TRACP 5b and CTX as osteological markers of delayed fracture healing

Moghaddam, Arash; Müller, Ulrich; Roth, Heinz Jürgen; Wentzensen, Andreas; Grützner, Paul Alfred; Zimmermann, G.

doi:10.1016/j.injury.2010.11.017

Cited by 70 publications

(94 citation statements)

References 34 publications

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“…An evaluation of the serum PINP levels derived from a collagen molecule revealed no differences between patients who, after undergoing a traumatic fracture, progressed into a non-union or a normal bone union (Moghaddam et al 2011), whereas PICP serum levels were higher in patients with delayed fracture healing by the 2 nd week after fracture than in patients undergoing a normal fracture healing process (p=0.07) (Joerring et al 1994). However, extrapolating the conclusions of this work should be done with some caution due to the small number of patients that the study groups comprised.…”

Section: Discussionmentioning

confidence: 95%

“…Emami et al (1999) observed that patients with delayed healing did not differ in cross-linked telopeptides, namely serum PYD levels, when compared with patients with normal fracture healing. In a study, Moghaddam et al (2011) observed that patients with delayed fracture healing presented lower serum CTX values early in the postoperative period than patients with normal bone union. Analogous results were found for total and free urinary HYP, with initially lower levels after the fracture in patients with impaired bone healing (Mukhopadhyay et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Klein et al (2004) No significant differences between the two groups. TRAP 5b Moghaddam et al (2011) Relative serum concentration was decreased at the 2 nd (p=0.0066) and 4 th week after surgery (p=0.0043) in delayed fracture healing as compared to patients who have developed a normal fracture healing process.…”

Section: Kurdy (2000)mentioning

confidence: 93%

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Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Sousa

Dias

López-Peña

et al. 2015

An. Acad. Bras. Ciênc.

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Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for improving accuracy in diagnosing complications following bone fractures. The variation in the levels of bone turnover markers (BTMs) have been assessed with regard to there ability to predict impaired fracture healing at an early stage, nevertheless the conclusions of some studies are not consensual. In this article the authors have revised the potential of BTMs as early predictors of prognosis in adult patients presenting traumatic bone fractures but who did not suffer from osteopenia or postmenopausal osteoporosis. The available information from the different studies performed in this field was systematized in order to highlight the most promising BTMs for the assessment of fracture healing outcome.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Sousa

Dias

López-Peña

et al. 2015

An. Acad. Bras. Ciênc.

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“…12 Nevertheless, our previous investigation in bone regeneration have shown that peripheral serum blood analysis may be a valid method for detecting complex human biochemical activities. 13 Therefore, we used a protocol that we established previously in our research on bone regeneration to determine whether sCD95L serum levels were upregulated in SCI patients.…”

Section: Introductionmentioning

confidence: 99%

Increase in soluble CD95L during subacute phases after human spinal cord injury: a potential therapeutic target

et al. 2012

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Study design: A pilot study measuring the levels of serum-soluble CD95 ligand (CD95L) in eight spinal cord-injured patients. Objectives: To determine the soluble concentration of CD95L in spinal cord injury (SCI) patients after trauma. Methods: We collected blood samples from eight patients with acute traumatic SCI. Soluble CD95L serum levels were determined using an enzyme-linked immunosorbent assay. American Spinal Injury Association (ASIA) was determined according to ASIA classification. The patients were monitored, and venous blood was drawn after arrival at the hospital on the 1st and 3rd day and during the 1st, 2nd, 4th, 8th and 12th weeks after trauma. Results: The average patient age was 48.1 years (18-86 years). Three patients were paraplegic (two incomplete, one complete), five were quadriplegic (one complete, four incomplete). The serum concentration of soluble CD95L (sCD95L) decreased during the 1st week (41 ng l À1 ) and increased after the 2nd week in all eight patients. It peaked during the 4th week (68.5 ng l À1 ) and reached a plateau during the 12th week (76.2 ng l À1 ). There are many possible explanations for not being able to detect a statistical significance, one of course being the small sample size. Conclusion: Promising results for anti-CD95L therapy have already been documented in lab studies with rodents. Anti-CD95L blocks the pro-apoptotic and proinflammatory activity of membrane-bound CD95L during the acute phase of SCI. We observed that sCD95L levels are elevated during the subacute and intermediate phases of SCI. It would be of great interest to study a larger group of patients to determine whether higher sCD95 levels are correlated with improved or impaired neurological outcome or with increasing levels of autoimmune components in peripheral blood.

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“…[5] Proinflammatory cytokines, including interleukin-1 (IL-1), IFN-γ and tumor necrosis factor-α (TNF-α) inhibit osteoblastic collagen production and interrupt formation of the bone matrix. [6,7] These cytokines also increase osteoclastic bone resorption.…”

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confidence: 99%

Can local administration of humic acid shorten recovery time of mandibular fractures? Experimental study

Durmuş¹,

Bora²,

Doğan³

et al. 2017

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TRACP 5b and CTX as osteological markers of delayed fracture healing

Cited by 70 publications

References 34 publications

Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Increase in soluble CD95L during subacute phases after human spinal cord injury: a potential therapeutic target

Can local administration of humic acid shorten recovery time of mandibular fractures? Experimental study

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