Tracking the urinary excretion of high molar mass poly(vinyl alcohol)

Besheer, Ahmed; Mäder, Karsten; Kaiser, Sergej; Kreßler, Jörg; Weis, Christine; Odermatt, Erich K.

doi:10.1002/jbm.b.30743

Cited by 18 publications

(25 citation statements)

References 47 publications

(65 reference statements)

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“…The PVA/CMC hydrogel separates the damaged peritoneal surfaces during the crucial remesothelialisation phase in the first two postoperative weeks and reduces initial adhesion formation [11][12][13]. This hydrogel is completely biodegradable, and no residues are found after two weeks [27].…”

Section: Discussionmentioning

confidence: 99%

Polyvinyl Alcohol Hydrogel Decreases Formation of Adhesions in a Rat Model of Peritonitis

Deerenberg

Mulder

Ditzel

et al. 2012

Surgical Infections

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Section: Discussionmentioning

confidence: 99%

Polyvinyl Alcohol Hydrogel Decreases Formation of Adhesions in a Rat Model of Peritonitis

Deerenberg

Mulder

Ditzel

et al. 2012

Surgical Infections

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“…The fate of PVA and its elimination from mammalian organisms were considered in several studies. Besheer et al135 employed spin labeling of 125 kDa sample of PVA and traced the intraperitoneal (i.p.) administered polymer in rabbit urine.…”

Section: Nanobiomedicinementioning

confidence: 99%

Poly(Vinyl Alcohol) Physical Hydrogels: New Vista on a Long Serving Biomaterial

Alves

Jensen

Smith

et al. 2011

Macromolecular Bioscience

209

159

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Poly(vinyl alcohol), PVA, and physical hydrogels derived thereof have an excellent safety profile and a successful history of biomedical applications. However, these materials are hardly in the focus of biomedical research, largely due to poor opportunities in nano- and micro-scale design associated with PVA hydrogels in their current form. In this review we aim to demonstrate that with PVA, a (sub)molecular control over polymer chemistry translates into fine-tuned supramolecular association of chains and this, in turn, defines macroscopic properties of the material. This nano- to micro- to macro- translation of control is unique for PVA and can now be accomplished using modern tools of macromolecular design. We believe that this strategy affords functionalized PVA physical hydrogels which meet the demands of modern nanobiotechnology and have a potential to become an indispensable tool in the design of biomaterials.

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“…The cleavage itself can happen through hydrolysis (e. g., of ester bonds),5, 6 by enzymatic cleavage,7 or miscellaneous mechanisms such as reduction of disulfide bonds,8 and can be in the main‐ or side chains,9 depending on the monomers and architecture of the polymer. In biodegradable materials, cleavage of the bonds results in water soluble polymer fragments, which can be excreted from the body, e.g., through the kidney 10. The degradation process of the polymer materials can be observed on different levels, including mass loss, change of molecular weight, change of thermomechanical properties, and the occurrence of degradation products.…”

Section: Introductionmentioning

confidence: 99%

Controlled Change of Mechanical Properties during Hydrolytic Degradation of Polyester Urethane Networks

Neffe

Tronci

Alteheld

et al. 2010

Macro Chemistry & Physics

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A. Alteheld Present Address: BASF Venture Capital GmbH, 4. Gartenweg -Z25, 67063 Ludwigshafen, Germany ---------Polyester urethane networks are versatile polymer systems as it is possible to tailor their mechanical properties and their hydrolytic degradation profile. For biomedical applications, the biodegradability as well as the thermomechanical properties of the polymer networks during the course of degradation is of importance. Therefore, we investigated the change of thermomechanical properties of networks based on star-shaped precursors of rac-dilactide and diglycolide, ε-caprolactone, or p-dioxanone, respectively, during hydrolytic degradation.Degradation rate and mechanical properties of the polymer networks were tailored by crosslink density, comonomers, and by changing the glass transition temperature. Most importantly, the degradation of the networks led to a controlled, step-by-step change of the mechanical properties of the networks. a Supporting information for this article is available at the bottom of the article's abstract page, which can be accessed from the journal's homepage at http://www.mrc-journal.de, or from the author. ((note: website is journal-specific)) b ATN and GT contributed equally to this work.-2 - IntroductionBiodegradable polymeric materials are the basis for implants needed for a certain time only and for which a second surgery for removal of the implant should be avoided, such as controlled drug release implants, [1] internal sutures, [2] and applications in tissue engineering and induced autoregeneration. [3,4] Principally, biodegradable materials are based on the cleavage of certain bonds under physiological conditions. The cleavage itself can happen through hydrolysis (e. g. of ester bonds), [5,6] by enzymatic cleavage, [7] or miscellaneous mechanisms such as reduction of disulfide bonds, [8] and can be in the main-or side chains, [9] depending on the monomers and architecture of the polymer. In biodegradable materials, cleavage of the bonds results in water soluble polymer fragments, which can be excreted from the body, e. g. through the kidney. [10] The degradation process of the polymer materials can be observed on different levels, including mass loss, change of molecular weight, change of thermomechanical properties, and the occurrence of degradation products. Additionally to degradation studies of bulk material, hydrolytic and enzymatic degradation can also be studied on polymer monolayers. [11] The degradation rate can generally be adjusted by the types of monomers, [12] the sequence structure and architecture of the polymer, [13][14][15][16] as well as by the morphology. One of the first and most-widely used classes of biodegradable polymers are the bulk degrading polyesters such as PLGA, however many other degradable materials are known such as poly(anhydrides), [17] poly(orthoesters), [18] poly(depsipeptides), [19] and poly(ether esters). [20] Semi-crystalline linear polyesters have been applied for sutures, for which mechanical stability is of high importance. O...

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Tracking the urinary excretion of high molar mass poly(vinyl alcohol)

Cited by 18 publications

References 47 publications

Polyvinyl Alcohol Hydrogel Decreases Formation of Adhesions in a Rat Model of Peritonitis

Polyvinyl Alcohol Hydrogel Decreases Formation of Adhesions in a Rat Model of Peritonitis

Poly(Vinyl Alcohol) Physical Hydrogels: New Vista on a Long Serving Biomaterial

Controlled Change of Mechanical Properties during Hydrolytic Degradation of Polyester Urethane Networks

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