Tracking the MDS Clone in Peripheral Blood (PB) Cells from Patients (pts) with Myelodysplastic Syndrome (MDS) Undergoing Azacitidine (AZAC)-Based Therapy.
Abstract:The genetic hallmark of MDS is a gain or loss of chromosomal loci identified in bone marrow (BM) cells in ∼50% of pts at diagnosis. We previously demonstrated in longitudinal chromosome study a modulating effect of chronic AZA C therapy on the MDS clone which subdivided patients into five distinct cytogenetic groups with statistically significant differences in survival (P=0.0003) (Najfeld et al, ASH 2004). Our goal was, therefore, to investigate whether PB cells can be used in substitute of BM cells for detec… Show more
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