Tracking the Effects of Tumor Treating Fields on Human Breast Cancer Cells in vitro Using a Capacitance Sensing Lab-on-CMOS Microsystem

Gilpin, Yann; Lin, Ching‐Yi; Forssell, Mats; Zheng, Siyang; Grover, Pulkit; Dandin, Marc

doi:10.1109/icecs202256217.2022.9971093

Cited by 2 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The biosensing platform used in this study included a microsystem configured for measuring cell proliferation and migration (Senevirathna et al ., 2016; B. P. Senevirathna et al ., 2019; B. Senevirathna, Lu, Dandin, et al ., 2019; Gilpin et al ., 2022). At its core, the microsystem included an application-specific integrated circuit (ASIC) fabricated in a 0.35 μm CMOS technology.…”

Section: Methodsmentioning

confidence: 99%

“…The microsystem included an integrative package capable of maintaining the chip’s electrical integrity while allowing liquid samples to be applied onto its sensing surface. The packaging procedure employed was described in previous publications (Dandin et al ., 2009; Datta-Chaudhuri, Abshire and Smela, 2014; Gilpin et al ., 2022). Briefly, it included attaching the ASIC die directly onto a PCB daughter board, which included a redistribution pad frame.…”

Section: Methodsmentioning

confidence: 99%

“…P. Senevirathna et al, 2019;B. Senevirathna, Lu, Dandin, et al, 2019;Gilpin et al, 2022). At its core, the microsystem included an applicationspecific integrated circuit (ASIC) fabricated in a 0.35 µm CMOS technology.…”

Section: Lab-on-cmos Biosensing Platformmentioning

confidence: 99%

See 2 more Smart Citations

Measuring and Modeling Macrophage Growth using a Lab-on-CMOS Capacitance Sensing Microsystem

Smith

Lin

Gilpin

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

We report on the use of a lab-on-CMOS biosensor platform for quantitatively tracking the growth of RAW 264.7 murine Balb/c macrophages. We show that macrophage growth over a wide sensing area correlates linearly with an average capacitance growth factor resulting from capacitance measurements at a plurality of electrodes dispersed in the sensing area. We further show a temporal model that captures the cell evolution in the area of interest over long periods (e.g., 30 hours). The model links the cell numbers and the average capacitance growth factor associated with the sensing area to describe the observed growth kinetics.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Measuring and Modeling Macrophage Growth using a Lab-on-CMOS Capacitance Sensing Microsystem

Smith

Lin

Gilpin

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The biosensing platform used in this study included a microsystem configured for measuring cell proliferation and migration (Senevirathna et al, 2016;Senevirathna et al, 2019c;Gilpin et al, 2022). At its core, the microsystem included an application-specific integrated circuit (ASIC) fabricated in a 0.35 µm CMOS technology.…”

Section: Lab-on-cmos Biosensing Platformmentioning

confidence: 99%

“…Furthermore, we have previously shown that the culture conditions that modulate cell proliferation rates yield differential capacitance responses. For example, we have shown cells cultured with growth rates inhibitors such as chemotherapeutics (Senevirathna et al, 2019b) and tumortreating fields (Gilpin et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Measuring and modeling macrophage proliferation in a lab-on-CMOS capacitance sensing microsystem

Smith

Lin

Gilpin

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

We report on the use of a lab-on-CMOS biosensor platform for quantitatively tracking the proliferation of RAW 264.7 murine Balb/c macrophages. We show that macrophage proliferation correlates linearly with an average capacitance growth factor resulting from capacitance measurements at a plurality of electrodes dispersed in a sensing area of interest. We further show a temporal model that captures the cell number evolution in the area over long periods (e.g., 30 h). The model links the cell numbers and the average capacitance growth factor to describe the observed cell proliferation.

show abstract

Tracking the Effects of Tumor Treating Fields on Human Breast Cancer Cells in vitro Using a Capacitance Sensing Lab-on-CMOS Microsystem

Cited by 2 publications

References 15 publications

Measuring and Modeling Macrophage Growth using a Lab-on-CMOS Capacitance Sensing Microsystem

Measuring and Modeling Macrophage Growth using a Lab-on-CMOS Capacitance Sensing Microsystem

Measuring and modeling macrophage proliferation in a lab-on-CMOS capacitance sensing microsystem

Contact Info

Product

Resources

About