Despite more than a decade of research on medical information systems, deficiencies exist in our capability of establishing an effective environmental health information infrastructure. In this research, we present a pilot study on creating a feasible environmental health information infrastructure. The newly-developed environmental health information system is a web-based platform that integrates databases, decision-making tools, geographic information systems for supporting public health service and policy making. The study, which is a part of a comprehensive effort known as Environmental Public Health Tracking proposed by the Center for Disease Control and Prevention, opens the door for future research on a large scale nation-wide healthcare information infrastructure.