Tracking pairwise genomic loci by the ParB–ParS and Noc-NBS systems in living cells
Xiaohui He,
Yuxi Tan,
Ying Feng
et al.
Abstract:The dynamics of genomic loci pairs and their interactions are essential for transcriptional regulation and genome organization. However, a robust method for tracking pairwise genomic loci in living cells is lacking. Here we developed a multicolor DNA labeling system, mParSpot (multicolor ParSpot), to track pairs of genomic loci and their interactions in living cells. The mParSpot system is derived from the ParB/ParS in the parABS system and Noc/NBS in its paralogous nucleoid occlusion system. The insertion of … Show more
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