Tracking of Metabolic Control from Childhood to Young Adulthood in Type 1 Diabetes

Hofer, Sabine E.; Raile, Klemens; Fröhlich‐Reiterer, Elke; Kapellen, Thomas; Dost, Axel; Rosenbauer, Joachim; Grulich‐Henn, Jürgen; Holl, Reinhard W.

doi:10.1016/j.jpeds.2014.07.001

Cited by 53 publications

(55 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, an association between QoL and HbA1c at each time point was observed in both studies, but Hilliard et al decided to exclude HbA1c at baseline and 6 months . We, however, included HbA1c as a fixed factor because of its relevance to HbA1c change (HbA1c tracking) and low variance inflation factors.…”

Section: Discussionmentioning

confidence: 61%

“…We did not observe any statistically significant relationship between baseline QoL and follow‐up HbA1c in the completely adjusted model. The predominant predictor of follow‐up HbA1c was baseline HbA1c in accordance with the known tracking of glycemic control during adolescence and emerging adulthood . Thus, this strong association may have superposed the association between baseline QoL and glycemic control at follow up, in particular as the association between QoL and HbA1c was stronger in the baseline data according to univariable regression.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Impact of quality of life (QoL) on glycemic control (HbA1c) among adolescents and emerging adults with long-duration type 1 diabetes: A prospective cohort-study

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 95%

Impact of quality of life (QoL) on glycemic control (HbA1c) among adolescents and emerging adults with long-duration type 1 diabetes: A prospective cohort-study

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Crucially, previous reports [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] have largely examined individuals with pre-existing type 1 diabetes (i.e. not from the time of diagnosis).…”

Section: Introductionmentioning

confidence: 99%

Clinically meaningful and lasting HbA1c improvement rarely occurs after 5 years of type 1 diabetes: an argument for early, targeted and aggressive intervention following diagnosis

et al. 2018

View full text Add to dashboard Cite

Aims/hypothesis Our objectives were to explore whether the phenomenon of HbA 1c 'tracking' occurs in individuals with type 1 diabetes, how long after diagnosis does tracking take to stabilise, and whether there is an effect of sex and age at diagnosis on tracking. Methods A total of 4525 individuals diagnosed with type 1 diabetes between 1 January 1995 and 1 May 2015 were identified from The Health Improvement Network (THIN) database. Mixed models were applied to assess the variability of HbA 1c levels over time with random effects on general practices (primary care units) and individuals within practices. Results 4525 individuals diagnosed with type 1 diabetes were identified in THIN over the study period. The greatest difference in mean HbA 1c measurement (−7.0 [95% CI −8.0, −6.1] mmol/mol [0.6%]) was seen when comparing measurements made immediately after diagnosis (0-1 year since diagnosis) with those at 10 or more years (the reference category). The mean difference in HbA 1c for the successive periods compared with 10 or more years after diagnosis declined and was no longer statistically significant after 5 years. In the stratified analysis using sex and age group there was considerable heterogeneity with adult onset type 1 diabetes appearing to track earlier and at a lower mean HbA 1c . Conclusions/interpretation In individuals with type 1 diabetes, glycaemic control measured by HbA 1c settles onto a long-term 'track' and this occurs on average by 5 years following diagnosis. Age at diagnosis modifies both the rate at which individuals settle into their track and the absolute HbA 1c tracking level for the next 10 years.

show abstract

“…Long‐term tracking of glycemic control from childhood until adulthood has been reported . There is a correlation between the HbA1c achieved within the first few months after diabetes diagnosis, the glycemic control later in life, and the risk for cardiovascular complications.…”

Section: Glycemic Targets and Control In Preschool Children With Typementioning

confidence: 99%

Managing diabetes in preschool children

et al. 2017

View full text Add to dashboard Cite

Tracking of Metabolic Control from Childhood to Young Adulthood in Type 1 Diabetes

Cited by 53 publications

References 31 publications

Impact of quality of life (QoL) on glycemic control (HbA1c) among adolescents and emerging adults with long-duration type 1 diabetes: A prospective cohort-study

Impact of quality of life (QoL) on glycemic control (HbA1c) among adolescents and emerging adults with long-duration type 1 diabetes: A prospective cohort-study

Clinically meaningful and lasting HbA1c improvement rarely occurs after 5 years of type 1 diabetes: an argument for early, targeted and aggressive intervention following diagnosis

Managing diabetes in preschool children

Contact Info

Product

Resources

About