Tracking mechanical wave propagation within tissue using phase-sensitive optical coherence tomography: motion artifact and its compensation

Song, Shaozhen; Huang, Zhihong

doi:10.1117/1.jbo.18.12.121505

Cited by 108 publications

(82 citation statements)

References 35 publications

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“…The raw phase signal from each position is then unwrapped over time and shifted to have the start of the phase profile at the value of zero. As the interferometric phase information represents the change of the optical path-length, the displacement from the corneal surface (cornea-air interface) affects the phase profiles measured at the underlying layers [59]. To correct these errors and obtain the true displacement profiles inside the cornea, we have developed algorithms of using the surface deformation to compensate the extra optical path-length change [50] [60] in our calculation.…”

Section: Data Processingmentioning

confidence: 99%

Noncontact depth-resolved micro-scale optical coherence elastography of the cornea

Wang

Larin

2014

Biomed. Opt. Express

152

127

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High-resolution elastographic assessment of the cornea can greatly assist clinical diagnosis and treatment of various ocular diseases. Here, we report on the first noncontact depth-resolved micro-scale optical coherence elastography of the cornea achieved using shear wave imaging optical coherence tomography (SWI-OCT) combined with the spectral analysis of the corneal Lamb wave propagation. This imaging method relies on a focused air-puff device to load the cornea with highly-localized lowpressure short-duration air stream and applies phase-resolved OCT detection to capture the low-amplitude deformation with nano-scale sensitivity. The SWI-OCT system is used here to image the corneal Lamb wave propagation with the frame rate the same as the OCT A-line acquisition speed. Based on the spectral analysis of the corneal temporal deformation profiles, the phase velocity of the Lamb wave is obtained at different depths for the major frequency components, which shows the depthwise distribution of the corneal stiffness related to its structural features. Our pilot experiments on ex vivo rabbit eyes demonstrate the feasibility of this method in depth-resolved micro-scale elastography of the cornea. The assessment of the Lamb wave dispersion is also presented, suggesting the potential for the quantitative measurement of corneal viscoelasticity. 3026-3031 (2007). 3. L. T. Nordan, "Keratoconus: diagnosis and treatment," Int. Ophthalmol. Clin. 37(1), 51-63 (1997). 4. C. Edmund, "Corneal elasticity and ocular rigidity in normal and keratoconic eyes," Acta Ophthalmol. (Copenh.) 66(2), 134-140 (1988 Biol. 93(1-3), 176-191 (2007). 17. G. Scarcelli and S. H. Yun, "Confocal Brillouin microscopy for three-dimensional mechanical imaging," Nat. ©2014 Optical Society of AmericaPhotonics 2(1), 39-43 (2008). 18. J. Schmitt, "OCT elastography: imaging microscopic deformation and strain of tissue," Opt. Express 3(6), 199-211 (1998). 19. G. Scarcelli and S. H. Yun, "In vivo Brillouin optical microscopy of the human eye," Opt. Express 20(8), 9197-9202 (2012). 20. G. Scarcelli, R. Pineda, and S. H. Yun, "Brillouin optical microscopy for corneal biomechanics," Invest.Ophthalmol. Vis. Sci. 53(1), 185-190 (2012). 21. G. Scarcelli, S. Kling, E. Quijano, R. Pineda, S. Marcos, and S. H. Yun, "Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus," Invest. Ophthalmol. Vis. Sci.

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Section: Data Processingmentioning

confidence: 99%

Noncontact depth-resolved micro-scale optical coherence elastography of the cornea

Wang

Larin

2014

Biomed. Opt. Express

152

127

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“…Nevertheless, this effect can be compensated using a map of the surface contour acquired by OCT, as described in Ref. 19. Hence, a single-sided approach is quite feasible and is currently under investigation in our lab and will be tested using both ex vivo and in vivo experiments.…”

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confidence: 99%

“…Note that wave propagation images are free from sample surface ripple artifacts commonly observed in OCT mechanical wave imaging, due to the layer of water acting as an optical coupling media. 19 Figure 3 shows how the temporal shape of the mechanical wave changes during propagation from the center of the excitation to the side in the X (lateral) direction for three different Z (depth) positions: close to the water interface (a), the phantom center (b), and air interface (c). It is clear that the waveform is not conserved even in the near field and even when the line source was used for excitation, i.e., wave propagation is strongly dispersive.…”

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confidence: 99%

Air-coupled acoustic radiation force for non-contact generation of broadband mechanical waves in soft media

Ambroziński

Pelivanov

Song

et al. 2016

Applied Physics Letters

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A non-contact method for efficient, non-invasive excitation of mechanical waves in soft media is proposed, in which we focus an ultrasound (US) signal through air onto the surface of a medium under study. The US wave reflected from the air/medium interface provides radiation force to the medium surface that launches a transient mechanical wave in the transverse (lateral) direction. The type of mechanical wave is determined by boundary conditions. To prove this concept, a homemade 1 MHz piezo-ceramic transducer with a matching layer to air sends a chirped US signal centered at 1 MHz to a 1.6 mm thick gelatin phantom mimicking soft biological tissue. A phasesensitive (PhS)-optical coherence tomography system is used to track/image the mechanical wave. The reconstructed transient displacement of the mechanical wave in space and time demonstrates highly efficient generation, thus offering great promise for non-contact, non-invasive characterization of soft media, in general, and for elasticity measurements in delicate soft tissues and organs in bio-medicine, in particular. Published by AIP Publishing. [http://dx.doi.org/10.1063/1.4959827] Acoustic radiation force (ARF) is commonly used in ultrasound (US)-based elastography to remotely generate shear waves deep within tissue. 1-3 Detection of shear waves can be performed with a conventional ultrasound (US) imaging probe or with another imaging method, e.g., optical coherence tomography (OCT). The combination of ARF with high frame rate OCT can produce quantitative crosssectional maps of the shear modulus in soft tissues. 4 For many clinical applications, however, a totally non-contact system for generation/detection of mechanical waves is desirable and, in some cases (for instance, the eye), is necessary. OCT is an ideal approach for these applications if an efficient and robust non-contact generation technology can be developed.Generation of mechanical waves with an air puff was used in Ref. 5 to produce very narrow bandwidth displacements in the cornea, which may not be able to characterize corneal elasticity at the spatial resolution required for clinical decision making. Our group has recently demonstrated non-contact generation using absorption of pulsed UV laser light. 6 Although UV generation can provide the bandwidth required for high spatial resolution maps of corneal elasticity, it is not clear at this point whether the required UV energy levels will meet the safety requirement for routine clinical use.Here we propose a fully non-contact and non-invasive US technique to create efficient localized wideband mechanical waves in soft tissue. The method utilizes US launched with an air-coupled transducer (i.e., through air) to the air/ medium interface. The US wave reflected from this interface provides radiation force to the medium surface, which induces a transient displacement at that surface, ultimately generating a propagating shear/guided/interface/Lamb wave (wave type determined by boundary conditions). We will call this the mechanical wave to maintain ge...

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“…Optical coherence elastography (OCE) is a technique that uses OCT for measuring the biomechanical properties of soft tissues [12,13]. The tissues can be excited internally or externally, and statically or dynamically.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples

Razani

Luk

Mariampillai

et al. 2014

Biomed. Opt. Express

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Abstract:In this work, we explored the potential of measuring shear wave propagation using optical coherence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a sweptsource optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, synchronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were composed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in gel. Differential OCT phase maps, measured with and without the ARF, detected the microscopic displacement generated by shear wave propagation in these phantoms and samples of different stiffness. We present the technique for calculating tissue mechanical properties by propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. This method lays the foundation for future in-vitro and in-vivo studies of mechanical property measurements of biological tissues such as vascular tissues, where normal and pathological structures may exhibit significant contrast in the shear modulus.

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Tracking mechanical wave propagation within tissue using phase-sensitive optical coherence tomography: motion artifact and its compensation

Cited by 108 publications

References 35 publications

Noncontact depth-resolved micro-scale optical coherence elastography of the cornea

Noncontact depth-resolved micro-scale optical coherence elastography of the cornea

Air-coupled acoustic radiation force for non-contact generation of broadband mechanical waves in soft media

Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples

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