2013
DOI: 10.1117/1.jbo.18.12.121505
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Tracking mechanical wave propagation within tissue using phase-sensitive optical coherence tomography: motion artifact and its compensation

Abstract: We describe theoretical and experimental investigations of motion artifacts that can arise in the detection of shear wave propagating within tissue with phase-sensitive optical coherence tomography. We find that the motion artifact is a combined product of sample surface motion and refractive index difference between sample and air, which cannot be neglected when estimating the tissue motion within tissue. A method of compensating the motion artifact is demonstrated, the results of which emphasize the need for… Show more

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Cited by 110 publications
(82 citation statements)
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“…The raw phase signal from each position is then unwrapped over time and shifted to have the start of the phase profile at the value of zero. As the interferometric phase information represents the change of the optical path-length, the displacement from the corneal surface (cornea-air interface) affects the phase profiles measured at the underlying layers [59]. To correct these errors and obtain the true displacement profiles inside the cornea, we have developed algorithms of using the surface deformation to compensate the extra optical path-length change [50] [60] in our calculation.…”
Section: Data Processingmentioning
confidence: 99%
“…The raw phase signal from each position is then unwrapped over time and shifted to have the start of the phase profile at the value of zero. As the interferometric phase information represents the change of the optical path-length, the displacement from the corneal surface (cornea-air interface) affects the phase profiles measured at the underlying layers [59]. To correct these errors and obtain the true displacement profiles inside the cornea, we have developed algorithms of using the surface deformation to compensate the extra optical path-length change [50] [60] in our calculation.…”
Section: Data Processingmentioning
confidence: 99%
“…Nevertheless, this effect can be compensated using a map of the surface contour acquired by OCT, as described in Ref. 19. Hence, a single-sided approach is quite feasible and is currently under investigation in our lab and will be tested using both ex vivo and in vivo experiments.…”
mentioning
confidence: 99%
“…Note that wave propagation images are free from sample surface ripple artifacts commonly observed in OCT mechanical wave imaging, due to the layer of water acting as an optical coupling media. 19 Figure 3 shows how the temporal shape of the mechanical wave changes during propagation from the center of the excitation to the side in the X (lateral) direction for three different Z (depth) positions: close to the water interface (a), the phantom center (b), and air interface (c). It is clear that the waveform is not conserved even in the near field and even when the line source was used for excitation, i.e., wave propagation is strongly dispersive.…”
mentioning
confidence: 99%
“…Optical coherence elastography (OCE) is a technique that uses OCT for measuring the biomechanical properties of soft tissues [12,13]. The tissues can be excited internally or externally, and statically or dynamically.…”
Section: Introductionmentioning
confidence: 99%