Tracking inflammation in the epileptic rat brain by bi-functional fluorescent and magnetic nanoparticles

Portnoy, Emma; Polyak, Boris; Inbar, Dorrit; Kenan, Gilad; Rai, Ahmad; Wehrli, Suzanne; Roberts, Timothy P.L.; Bishara, Ameer; Mann, Aniv; Shmuel, Miriam; Rozovsky, Katya; Itzhak, Gal; Ben‐Hur, Tamir; Magdassi, Shlomo; Ekstein, Dana; Eyal, Sara

doi:10.1016/j.nano.2016.01.018

Cited by 29 publications

(17 citation statements)

References 49 publications

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“…In addition, Breuer and colleagues reported higher sensitivity of gadolinium-enhanced T1-weighted MRI compared to 68 Ga-DTPA PET and 99m Tc-DTPA SPECT in detecting BBB impairment following SE in rats (Breuer et al, 2017). Another approach recently described involves the employment of iron-filled nanoparticles as contrast agent to monitor brain distribution of iron-labeled transplanted bone marrow stem cells in rats (Long et al, 2015) or brain uptake by myeloid cells in pilocarpine SE-induced mice (Portnoy et al, 2016).…”

Section: Gadolinium and Iron Oxide Contrast Mrimentioning

confidence: 99%

Neuroimaging in animal models of epilepsy

et al. 2017

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Epilepsy is one of the most common chronic neurological conditions worldwide. The current poor understanding and lack of reliable biomarkers of the epileptogenic process are the major limitations in the development of anti-epileptic drugs that are able to prevent or modify the underlying disease. The rapid progress in advanced imaging technologies has expanded our opportunities to study the disease in animal models of epilepsy by means of non-invasive research tools. Here we review the advances of different in vivo imaging techniques, including magnetic resonance-based and nuclear imaging-based modalities, in animal models of epilepsy. Together these techniques can be applied to visualize and quantify structural, metabolic, functional and molecular changes in longitudinal study designs to provide unique information about early pathophysiological changes and their interplay involved in epileptogenesis, monitoring the disease progression, assessing the effectiveness of possible therapies, and potentially identify translatable biomarkers for clinical use.

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Section: Gadolinium and Iron Oxide Contrast Mrimentioning

confidence: 99%

Neuroimaging in animal models of epilepsy

et al. 2017

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“…Studies with iron oxide contrast MRI have been conducted in pilocarpine-induced SE models. Iron-filled nanoparticles have been used to detect myeloid cells during chronic SE [42]. Another study used iron T2-weighted MRI to track transplanted iron-labeled bone marrow stem cells in pilocarpine-induced SE [43].…”

Section: Mri and Subtypes In Preclinical Models Of Epilepsymentioning

confidence: 99%

Neuroimaging Biomarkers of Experimental Epileptogenesis and Refractory Epilepsy

Reddy

Younus

Sridhar

et al. 2019

IJMS

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This article provides an overview of neuroimaging biomarkers in experimental epileptogenesis and refractory epilepsy. Neuroimaging represents a gold standard and clinically translatable technique to identify neuropathological changes in epileptogenesis and longitudinally monitor its progression after a precipitating injury. Neuroimaging studies, along with molecular studies from animal models, have greatly improved our understanding of the neuropathology of epilepsy, such as the hallmark hippocampus sclerosis. Animal models are effective for differentiating the different stages of epileptogenesis. Neuroimaging in experimental epilepsy provides unique information about anatomic, functional, and metabolic alterations linked to epileptogenesis. Recently, several in vivo biomarkers for epileptogenesis have been investigated for characterizing neuronal loss, inflammation, blood-brain barrier alterations, changes in neurotransmitter density, neurovascular coupling, cerebral blood flow and volume, network connectivity, and metabolic activity in the brain. Magnetic resonance imaging (MRI) is a sensitive method for detecting structural and functional changes in the brain, especially to identify region-specific neuronal damage patterns in epilepsy. Positron emission tomography (PET) and single-photon emission computerized tomography are helpful to elucidate key functional alterations, especially in areas of brain metabolism and molecular patterns, and can help monitor pathology of epileptic disorders. Multimodal procedures such as PET-MRI integrated systems are desired for refractory epilepsy. Validated biomarkers are warranted for early identification of people at risk for epilepsy and monitoring of the progression of medical interventions.

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“…The authors suggested that this nanoprobe could be used as MRI contrast agent because of its superparamagnetic properties [108]. Poly(lactic)acid NP impregnated with magnetite (as MRI probe) and labeled with an NIR BODIPY dye (as optical imaging probe) was produced and could be visualized by ex vivo MRI and confocal microscopy in the hippocampal brain tissue of epileptic rats [109].…”

Section: Bodipy-based Bimodal Optical Imaging / Mri Agentsmentioning

confidence: 99%

Metal-based BODIPY derivatives as multimodal tools for life sciences

Bertrand

Passador

Goze

et al. 2018

Coordination Chemistry Reviews

108

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International audienceNowadays, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene – better known as BODIPY – is at the forefront of fluorophores for life sciences. Indeed, its high brightness, its tunable excitation and emission wavelengths along with its high chemical and photochemical stability draw more and more the interest of researchers. In the last decade, chemists have taken advantage of the versatility of the synthesis of BODIPY to design sophisticated objects. This review focuses on the different recent studies dealing with the conception of metal-based-BODIPY derivatives for medical purposes. More precisely, emphasis is put on the use of BODIPY derivatives for the elaboration of BODIPY-based theranostics, multimodal imaging probes, and photodynamic therapy sensitizers

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Tracking inflammation in the epileptic rat brain by bi-functional fluorescent and magnetic nanoparticles

Cited by 29 publications

References 49 publications

Neuroimaging in animal models of epilepsy

Neuroimaging in animal models of epilepsy

Neuroimaging Biomarkers of Experimental Epileptogenesis and Refractory Epilepsy

Metal-based BODIPY derivatives as multimodal tools for life sciences

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