Tracking Early Systolic Motion for Assessing Acute Response to Cardiac Resynchronization Therapy in Real Time

Villegas-Martínez, Manuel; Krogh, Magnus Reinsfelt; Andersen, O.; Sletten, OJ; Wajdan, Ali; Odland, Hans Henrik; Elle, Ole Jakob; Remme, Espen W.

doi:10.3389/fphys.2022.903784

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…A pair was implanted subendocardially in a long-axis-diameter pair (apex to base), and two other pairs were placed subendocardially in the LV equator (posterior to anterior wall and septum to the lateral wall). From these three diameter pairs, the continuous LV volume was estimated using the formula 17 :…”

Section: Methodsmentioning

confidence: 99%

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Pulse arrival time variation as a non-invasive marker of acute response to cardiac resynchronization therapy

et al. 2023

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Aims Successful cardiac resynchronization therapy (CRT) shortens the pre-ejection period (PEP) which is prolonged in the left bundle branch block (LBBB). In a combined animal and patient study, we investigated if changes in the pulse arrival time (PAT) could be used to measure acute changes in PEP during CRT implantation and hence be used to evaluate acute CRT response non-invasively and in real time. Methods and results In six canines, a pulse transducer was attached to a lower limb and PAT was measured together with left ventricular (LV) pressure by micromanometer at baseline, after induction of LBBB and during biventricular pacing. Time-to-peak LV dP/dt (Td) was used as a surrogate for PEP. In twelve LBBB patients during implantation of CRT, LV and femoral pressures were measured at baseline and during five different pacing configurations. PAT increased from baseline (277 ± 9 ms) to LBBB (313 ± 16 ms, P < 0.05) and shortened with biventricular pacing (290 ± 16 ms, P < 0.05) in animals. There was a strong relationship between changes in PAT and Td in patients (r2 = 0.91). Two patients were classified as non-responders at 6 months follow-up. CRT decreased PAT from 320 ± 41 to 298 ± 39 ms (P < 0.05) in the responders, while PAT increased by 5 and 8 ms in the two non-responders. Conclusion This proof-of-concept study indicates that PAT can be used as a simple, non-invasive method to assess the acute effects of CRT in real time with the potential to identify long-term response in patients.

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Section: Methodsmentioning

confidence: 99%

“…This preload-corrected SW, SW EDV , was obtained from the beats with the highest common EDV values from baseline, LBBB and CRT recordings and used as an index of global cardiac performance. 17 …”

Section: Methodsmentioning

confidence: 99%

Pulse arrival time variation as a non-invasive marker of acute response to cardiac resynchronization therapy

et al. 2023

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Enhancing offloading with cybersecurity in edge computing for digital twin‐driven patient monitoring

Jameil,

Al‐Raweshidy

2024

IET Wireless Sensor Systems

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In healthcare, the use of digital twin (DT) technology has been recognised as essential for enhancing patient care through real‐time remote monitoring. However, concerns regarding risk prediction, task offloading, and data security have been raised due to the integration of the Internet of Things (IoT) in remote healthcare. In this study, a new method was introduced, combines edge computing with sophisticated cybersecurity solutions. A vast amount of environmental and physiological data has been gathered, allowing for thorough understanding of patients. The system included hybrid encryption, threat prediction, Merkle Tree verification, certificate‐based authentication, and secure communication. The feasibility of the proposal was evaluated by using an ESP32‐Azure IoT Kit and Azure Cloud to evaluate the system's capacity to securely send patient data to healthcare institutions and stakeholders, while simultaneously upholding data confidentiality. The system demonstrated a notable improvement in encryption speed, with 27.18%, represented as the improved efficiency and achieved storage efficiency ratio 0.673. Furthermore, the evidence from the simulations showed that the system's performance was not affected by encryption since encryption times continuously remained within a narrow range. Moreover, proactive alert of probable security risks would be detected from the predictive analytics, hence strong data integrity assurance. The results suggest the proposed system provided a proactive, personalised care approach for cybersecurity‐protected DT healthcare (DTH) high‐level modelling and simulation, enabled via IoT and cloud computing under improved threat prediction.

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Tracking Early Systolic Motion for Assessing Acute Response to Cardiac Resynchronization Therapy in Real Time

Cited by 2 publications

References 35 publications

Pulse arrival time variation as a non-invasive marker of acute response to cardiac resynchronization therapy

Pulse arrival time variation as a non-invasive marker of acute response to cardiac resynchronization therapy

Enhancing offloading with cybersecurity in edge computing for digital twin‐driven patient monitoring

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