Track-structure modes in particle and heavy ion transport code system (PHITS): application to radiobiological research

Matsuya, Yusuke; Kai, Takeshi; Sato, Tatsuhiko; Ogawa, Tatsuhiko; Hirata, Yuho; Yoshii, Yukie; Parisi, Amilcare; Liamsuwan, T.

doi:10.1080/09553002.2022.2013572

Cited by 21 publications

(23 citation statements)

References 99 publications

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“…42,59 Given this, a more sophisticated treatment of the delayed light taking into account the excitation and ionization density distributions in the medium is required to accurately describe the specific luminescence. Recent advances in track structure modeling [60][61][62][63][64] provide a potential path forward.…”

Section: Impact Of the Nature Of The Heavy Charged Particlementioning

confidence: 99%

Modeling ionization quenching in organic scintillators

et al. 2022

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Section: Impact Of the Nature Of The Heavy Charged Particlementioning

confidence: 99%

Modeling ionization quenching in organic scintillators

et al. 2022

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“…The PHITS code version 3.27 21 was used for simulating electron tracks in liquid water. In the PHITS simulations, the [track-structure] section was activated within liquid water, which enables us to calculate each atomic interaction (i.e., elastic scattering, ionization, electronic excitation, dissociative electron attachment, vibrational excitation, rotational excitation and phonon excitation) along an electron track based on etsmode 25 , 26 . To consider the Lorentz force in the PHITS simulation, we also used the [magnetic field] section for electrons.…”

Section: Methodsmentioning

confidence: 99%

“…For dealing with the above issues, Particle and Heavy Ion Transport code System (PHITS) 21 is appropriate because the dynamics of low-energy electrons down to 10 –3 eV in liquid water 22 , 23 can be analysed using the electron track-structure mode, etsmode , even in magnetic fields, where the types and the yields of DNA damage are determined based on the spatial patterns of atomic interactions 24 , 25 . In this study, we estimate the physical features of electron tracks (i.e., ranges, dose distributions, etc.)…”

Section: Introductionmentioning

confidence: 99%

Impact of the Lorentz force on electron track structure and early DNA damage yields in magnetic resonance-guided radiotherapy

Yachi

Kai

Matsuya

et al. 2022

Sci Rep

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Magnetic resonance-guided radiotherapy (MRgRT) has been developed and installed in recent decades for external radiotherapy in several clinical facilities. Lorentz forces modulate dose distribution by charged particles in MRgRT; however, the impact of Lorentz forces on low-energy electron track structure and early DNA damage induction remain unclear. In this study, we estimated features of electron track structure and biological effects in a static magnetic field (SMF) using a general-purpose Monte Carlo code, particle and heavy ion transport code system (PHITS) that enables us to simulate low-energy electrons down to 1 meV by track-structure mode. The macroscopic dose distributions by electrons above approximately 300 keV initial energy in liquid water are changed by both perpendicular and parallel SMFs against the incident direction, indicating that the Lorentz force plays an important role in calculating dose within tumours. Meanwhile, DNA damage estimation based on the spatial patterns of atomic interactions indicates that the initial yield of DNA double-strand breaks (DSBs) is independent of the SMF intensity. The DSB induction is predominantly attributed to the secondary electrons below a few tens of eV, of which energy deposition patterns are not considerably affected by the Lorentz force. Our simulation study suggests that treatment planning for MRgRT can be made with consideration of only changed dose distribution.

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“…Simulation setup for electron transport in SMF PHITS code version 3.26 22 was used for simulating electron tracks in liquid water. In the PHITS simulations, the [track-structure] section was activated within liquid water, which enables us to calculate each atomic interaction (i.e., elastic scattering, ionization, electron excitation, dissociative electron attachment, vibrational excitation, rotational excitation and phonon excitation) along an electron track based on etsmode 31,32 . To consider the Lorentz force in the PHITS simulation, we also used the [magnetic eld] section for electrons and positions.…”

Section: Methodsmentioning

confidence: 99%

“…For dealing with the above issues, Particle and Heavy Ion Transport code System (PHITS) 22 is appropriate because the dynamics of low-energy electrons down to 10 −3 eV in liquid water [23][24][25][26][27][28] can be analysed using the electron track-structure mode, etsmode, even in magnetic elds, where the types and the yields of DNA damage are determined based on the spatial patterns of atomic interactions. [29][30][31] In this study, we estimate the physics features of electron tracks (i.e., ranges, dose distributions, etc.) in SMFs and the early DNA damage yields through physics process simulations.…”

Section: Introductionmentioning

confidence: 99%

Impact of the Lorentz Force on Electron Track Structure and Early DNA Damage Yields in Magnetic Resonance-Guided Radiotherapy

Yachi

Kai

Matsuya

et al. 2022

Preprint

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Magnetic resonance-guided radiotherapy (MRgRT) has been developed and installed in recent decades for external radiotherapy in several clinical facilities. The Lorentz force modulates dose distribution by charged particles in MRgRT; however, the impact by this force on low-energy electron track structure and early DNA damage induction remain unclear. In this study, we estimated features of electron track structure and biological effects in a static magnetic field (SMF) using a general-purpose Monte Carlo code, Particle and Heavy Ion Transport code System (PHITS) that enables us to simulate low-energy electrons down to 1 meV by track-structure mode. The macroscopic dose distributions by electrons above approximately 300 keV initial energy in liquid water are changed by both perpendicular and parallel SMFs against the incident direction, indicating that the Lorentz force plays an important role in calculating dose within tumours. Meanwhile, DNA damage estimation based on the spatial patterns of atomic interactions indicates that the initial yield of DNA double-strand breaks (DSBs) is independent of the SMF intensity. The DSB induction is predominantly attributed to the secondary electrons below a few tens of eV, which are not affected by the Lorentz force. Our simulation study suggests that treatment planning for MRgRT can be made with consideration of only changed dose distribution.

show abstract

Track-structure modes in particle and heavy ion transport code system (PHITS): application to radiobiological research

Cited by 21 publications

References 99 publications

Modeling ionization quenching in organic scintillators

Modeling ionization quenching in organic scintillators

Impact of the Lorentz force on electron track structure and early DNA damage yields in magnetic resonance-guided radiotherapy

Impact of the Lorentz Force on Electron Track Structure and Early DNA Damage Yields in Magnetic Resonance-Guided Radiotherapy

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